Our works

LaRock D, Sands J, Ettouati E, Richard M, Bushway P, Adler E, Nizet V, LaRock C. Inflammasome inhibition protects against cardiac glycoside cellular toxicity. The Journal of Biological Chemistry (2019)

Dan J, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales S, Anderson E, LaRock C, Seumois G, Layfield D, Cutress R, Ottensmier C, Arlehamn C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Science Translational Medicine (2019)

Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics (2018)

Valderrama J, Riestra A, Gao N, LaRock C, Ali S, Gupta N, Hoffman H, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nature Microbiology (2017)

Döhrmann S, LaRock C, Anderson E, Cole J, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones. Scientific Reports (2017)

LaRock C & Nizet V. Inflammasome/IL-1β responses to streptococcal pathogens. Frontiers Immunology (2016)

LaRock C, Döhrmann S, Todd J, Corriden R, Johannssen T, Lepenies B, Gallo R, Ghosh P, Nizet V. Group A streptococcal M1 protein sequesters cathelicidin to evade innate immune killing. Cell Host & Microbe (2015)

LaRock C & Nizet V. Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. BBA Biomembranes (2015)

Barnett T, Liebl D, Seymour L, Gillen C, Lim J, LaRock C, Davies M, Schulz B, Nizet V, Teasdale R, Walker M. The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication. Cell Host & Microbe (2013)

LaRock C & Cookson B. Burning down the house: cell actions during pyroptosis. PLoS Pathogens (2013)

LaRock C, Yu J, Horswill A, Parsek M, Minion F. Transcriptome analysis of acyl-homoserine lactone based quorum sensing regulation in Yersinia pestis. PLoS One (2013)

LaRock C & Cookson B. The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing. Cell Host & Microbe (2012)

Livny J, LaRock C, Friedman D. Identification and isolation of lysogens with induced prophage. Methods in Molecular Biology (2009)

Tchesnokova V, Aprikian P, Yakovenko O, LaRock C, Kidd B, Vogel V, Thomas W, Sokurenko E. Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli. The Journal of Biological Chemistry (2008)

Held K, LaRock C, D'Argenio D, Berg C, Collins C. A metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization. Applied & Environmental Microbiology (2007)