Nan-Si Li (李南熺)

Sponsored Researcher

Nan-Si Li Profile | Imperial College London 

Affiliation：

Centre for Bio-Inspired Technology, Department of Electrical and Electronic Engineering, 

Imperial College London, United Kingdom

Degree：

2021 The Ph.D. of Biomedical Sciences, NSYSU, Taiwan

2017 The M.S. of Medical Science and Technology, NSYSU, Taiwan

2015 The B.S. of Computer Science and Technology, NQU, Taiwan

Research field：

Development of nanomaterials-based biosensing platform for healthcare applications

E-mail：

nansi.li@imperial.ac.uk

Scholar Accomplishments：

• The 2025 Academic Medal for Outstanding Paper from Association of Chemical Sensors in Taiwan.

• The 2024 Young Author Grant Award  in the 15th Asian Conference On Chemical Sensor (ACCS2024 in Kitakyushu, Japan)

• The 2023 Postdoctoral Researcher Academic Research Award from National Science and Technology Council, Taiwan (112年度國家科學及技術委員會博士後研究人員學術研究獎)

• The 2023 20th National Innovation Award, Taiwan；第二十屆國家新創獎-學研新創 (創新核酸自動生產封裝技術:加速癌症基因靜默治療商業化)

• The third Prize Young Scholar Oral Presentaiton Award in the International Conference on Precision Nanomedicine in Theranostics & the 2023 Annual Meeting of Taiwan Nanomedicine Society.

• The 2023 Sakura Science Exchange Program at the Univ. of Fukui, funded by Japan Science and Technology Agency.

• The Distinguished Oral Paper Award in 2022 ICSS.

• The 2022 Academic Medal for Outstanding Paper from Association of Chemical Sensors in Taiwan.

• The 2022 (109) Outstanding Doctoral Thesis from National Sun Yat-Sen University.

• The 2021 18th National Innovation Award, Taiwan；第十八屆國家新創獎-臨床新創 (即時快速奈米檢測POCT平台作為膀胱癌之健康照護)

• The 2021 Academic Medal for Outstanding Paper from Association of Chemical Sensors in Taiwan.

• The 2021 Ping An Elite Education Foundation PhD Scholarship.

• The Best Student English Oral Presentation Award in 2020 ICSS.

• The 2020 PhD Student Award from Association of Chemical Sensors in Taiwan.

• The 2020 PhD Research Award from National Sun Yat-sen University.

• The 2020 Academic Medal for Outstanding Paper from Association of Chemical Sensors in Taiwan.

• The 2019 Academic Medal for Outstanding Paper from Association of Chemical Sensors in Taiwan.

• The Excellent Student English Oral Presentation Award in 2019 ICSS. 

Employment History：

2025.04 - now Sponsored Researcher at Imperial College London

2024.09 - 2025.04 Postdoctoral Researcher at National Cheng Kung University

2022.08 - 2024.08 Research and Development Substitute Services at National Cheng Kung University (研發替代役)

2021.09 - 2022.07 Research and Development Substitute Services at National Sun Yat-sen University (研發替代役)

2020 - 2021 Adjunct doctoral researcher at Kaohsiung Chang Gung Memorial Hospital

2015 - 2021 Research assistant at National Sun Yat-sen University 

Patent applications:

(Titles in their original language formats.)

1. Method for Manufacturing Biosensor and Biosensor Manufactured by the Same (US20220099616A1) / 生物感測器的製造方法及以該製造方法所製得的生物感測器 (I803001) / 生物传感器的制造方法及以该制造方法所制得的生物传感器(CN114279980B)

2. Fusion Peptide for Forming Virus-Like Particle (US20220098236A1) / 用以形成類病毒顆粒的融合胜 (TW202214670A) / 用以形成类病毒颗粒的融合胜肽 (CN114276459A)

Publications:

1. Y.P. Hsu#, N.S. Li#, H.H. Pang, Y.C. Pan, H.P. Tsai, H.C. Chen, Y.T. Chen, C.H. Weng, S.W. Kuo*, H.W. Yang*. Lab-on-the-Needles: A Microneedle Patch-Based Mobile Unit for Highly Sensitive Ex Vivo and In Vivo Detection of Protein Biomarkers. 

ACS Nano 19, 3249–3264 (2025).  (IF = 15.8)  https://doi.org/10.1021/acsnano.4c11238  (Journal Cover)

2. N.S. Li#, Y.P. Hsu#, H.H. Pang, S.F. Wang, S.T. Pang, C.Y. Lin, R.Y. Tsai, C.Y. Huang, K.C. Wei, H.W. Yang*. Lab-in-a-Vial Rapid Test for Internet of Things Imbedded Point-of-Healthcare Protein Biomarker Detections in Bodily Fluids. 

Small, Volume 20, Issue 50, 2470369  (2024). (IF = 13.0) https://doi.org/10.1002/smll.202470369 (Inside Front Cover) 

3. N.S. Li#, K.A. Cheng#, Y.P. Hsu, H.W. Yang*. Metal-Organic Framework-Based Off-On Fluorescent Probe for Highly Selective and Sensitive Phosphate Detection. 

Nano Trends, Volume 7, 100051 (2024). https://doi.org/10.1016/j.nwnano.2024.100051

4. H.H Pang, N.S Li, Y.P. Hsu, S.P. Ju, G.D. Syu, P.X. Du, C.Y. Huang, K.C. Wei*, H.W. Yang*. AI-Driven Design System for Fabrication of Inhalable Nanocatchers for Virus Capture and Neutralization. 

Advanced Healthcare Materials, Volume 13, Issue 5, 2302927 (2024). (IF = 10.0) (Cover)

5. H.H. Pang, C.Y. Huang, P.Y. Chen, N.S. Li, Y.P. Hsu, J.K. Wu, H.F. Fan, K.C. Wei*, H.W. Yang*. Bioengineered bacteriophage-like nanoparticles as RNAi therapeutics to enhance radiotherapy against glioblastomas. 

ACS Nano 17, 10407–10422 (2023). (IF = 15.8) (Cover)

6. Y.J. Chen#, Y.P. Hsu#, Y.L. Tain#, N.S. Li, H.H. Pang, S.W. Kuo*, H.W. Yang*. Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic. 

Biosensors and Bioelectronics 208, 114234 (2022). (IF = 10.7)  

7. N.S. Li#, Y.T. Chen#, Y.P. Hsu, H.H. Pang, C.Y. Huang, Y.L. Shiue, K.C. Wei*, H.W. Yang*. Mobile healthcare system based on the combination of lateral flow pad and smartphone for rapid detection of uric acid detection in whole blood. 

Biosensors and Bioelectronics 164, 112309 (2020). (IF = 10.7)  https://doi.org/10.1016/j.bios.2020.112309

8. H.H. Pang#, Y.C. Ke#, N.S. Li, Y.T. Chen, C.Y. Huang, K.C. Wei*, H.W. Yang*. A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level. 

Biosensors and Bioelectronics 165, 112325 (2020). (IF = 10.7) https://doi.org/10.1016/j.bios.2020.112325

9. Y.P. Hsu#, H.W. Yang#,*, N.S. Li, Y.T. Chen, H.H. Pang, S.T. Pang*. Instrument-Free Detection of FXYD3 Using Vial-Based Immunosensor for Earlier and Faster Urothelial Carcinoma Diagnosis. 

ACS Sensors 5,928-935 (2020).  (IF = 8.2)

10. Y.P. Hsu#, N.S. Li#, Y.T. Chen, H.H. Pang, K.C. Wei, H.W. Yang*. A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone.  

Biosensors and Bioelectronics 151, 111960 (2020). (IF = 10.7) https://doi.org/10.1016/j.bios.2019.111960

11. N.S. Li#, W.L. Lin#, Y.P. Hsu, Y.T. Chen, Y.L. Shiue, H.W. Yang*. Combined Detection of CA19-9 and MUC1 Using a Colorimetric Immunosensor Based on Magnetic Gold Nanorods for Ultrasensitive Risk Assessment of Pancreatic Cancer. 

ACS Applied Bio Materials 2, 4847-4855 (2019).(IF = 4.6)

12. P.C. Lee#, N.S. Li#, Y.P. Hsu, C. Peng, H.W. Yang*. Direct glucose detection in whole blood by colorimetric assay based on glucose oxidase-conjugated graphene oxide/MnO2 nanozymes. 

Analyst 144, 3038-3044 (2019). (IF = 3.6)

13. C. Peng#, M.Y. Hua#, N.S. Li, Y.P. Hsu, Y.T. Chen, C.K. Chuang, S.T. Pang*, H.W. Yang*. A colorimetric immunosensor based on self-linkable dual-nanozyme for ultrasensitive bladder cancer diagnosis and prognosis monitoring. 

Biosensors and Bioelectronics 126, 581-589 (2019). (IF = 10.7)

Invited Speech:

1. Application of NanoBiomaterials in Pandemic Prevention. International Conference on Future Healthcare and Economic Development (FHED Conference 2022), Tainan, Taiwan (2022, Nov.)

Conference Presentation:

1. N.S. Li, Y.P. Hsu, H.H. Pang, H. W. Yang* (2024, Nov.). Lab-in-a-Vial Rapid Test for Internet of Things Imbedded Point-of-Healthcare Protein Biomarker Detections in Bodily Fluids. The 15th Asian Conference on Chemical Sensors 2024 (ACCS2024), Kitakyushu, Japan.

2. Y.P. Hsu, N.S. Li, H. W. Yang* (2024, Jul.) Microneedle patch-based SenBox for highly sensitive detection and quantification of protein biomarkers in viscous liquid biopsy. 2024 International Conference on Smart Sensors (2024 ICSS), Tainan, Taiwan.

3. N.S. Li, Y.P. Hsu, H.H. Pang, H. W. Yang* (2023, Nov.). EasyVial: A Revolution in On-Site Personal ELISA-like Rapid Detection and Quantification of Protein Biomarkers Using Platinum Nanozymes: Applications in SARS-CoV-2 Antibodies and Bladder Cancer Diagnostics. The 14th Asian Conference on Chemical Sensors 2023 (ACCS2023), Manila, Philippines.

4. Y.P. Hsu, Y.J Chen, N.S. Li, H. W. Yang* (2023, Nov.). Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic. The 14th Asian Conference on Chemical Sensors 2023 (ACCS2023), Manila, Philippines.

5. N.S. Li, H.H. Pang Y.P. Hsu, H. W. Yang* (2023, Sep.). AI designed Modular Recombinant self-assembly protein system as Viral Entry Blocker for Pandemic Prevention. The 33rd Annual Conference of the European Society for Biomaterials (ESB2023), Davos, Switzerland.

6. N.S. Li, Y.P. Hsu, H.H. Pang, H. W. Yang* (2023, Jul.). Revolutionary rapid testing vials kits for the ultrasensitive detection of early COVID-19 patients with asymptomatic seroconversion. International Conference on Precision Nanomedicine in Theranostics & the 2023 Annual Meeting of Taiwan Nanomedicine Society, Taichung, Taiwan.

7. Y.Z Wang, H.H Pang, N.S. Li, Y.P. Hsu, H. W. Yang* (2023, Jul.). Self-assembly induced-charge electrophoretic nanaosensors for high throughtput detection of ovarian cancer biomarker HE4 and CA125. International Conference on Precision Nanomedicine in Theranostics & the 2023 Annual Meeting of Taiwan Nanomedicine Society, Taichung, Taiwan.

8. N.S Li, Y.P. Hsu, H. W. Yang* (2023, Jun.). Revolutionary rapid testing vials kits for the ultrasensitive detection of early COVID-19 patients with asymptomatic seroconversion. 33rd Anniversary World Congress on Biosensors, Busan, South Korea.

9. Y.P. Hsu, N.S Li, H. W. Yang* (2023, Jun.).  An ultrasensitive and rapid COVID-19 IgA and Spike RBD test in clinical saliva samples based on 3D-microneedle patches. 33rd Anniversary World Congress on Biosensors, Busan, South Korea.

10. Y.P. Hsu, N.S Li, H. W. Yang* (2023, Jun.). An ultrasensitive and rapid COVID-19 test based on 3D-microneedle patches for IgA and Spike/RBD in clinical saliva samples. 2023 International Conference on Smart Sensors (2023 ICSS), Tainan, Taiwan.

11. Y.Z. Wang, H.H. Pang, N.S Li, Y.P. Hsu, H. W. Yang* (2023, Jun.). Self-assembly induced-charge electrophoretic nanosensors for high throughput detection of ovarian cancer biomarker HE4 and CA125. 2023 International Conference on Smart Sensors (2023 ICSS), Tainan, Taiwan.

12. N.S Li, Y.P. Hsu, H.H. Pang, H. W. Yang* (2022, Oct.). Revolutionary rapid testing vials kits for the ultrasensitive detection of early COVID-19 patients with asymptomatic seroconversion. 2022 International Conference on Smart Sensors (2022 ICSS), Taichung, Taiwan.

13. Y.P. Hsu, N.S Li, H. W. Yang* (2022, Oct.).  An ultrasensitive and rapid COVID-19 IgA and Spike RBD test in clinical saliva samples based on 3D microneedle patches. 2022 International Conference on Smart Sensors (2022 ICSS), Taichung, Taiwan.

14. Y.P. Hsu, N.S. Li, H.W. Yang* (2022, Jul). An ultrasensitive and rapid COVID-19 test based on 3D-microneedle patches for IgA and Spike RBD in clinical saliva samples. International Conferenceon Precision Nanomedicine in Theranostics & the 2022 Annual Meeting of Taiwan Nanomedicine Society (2022 TNSC), Hsinchu, Taiwan.

15. Y.P. Hsu, N.S Li, H.W. Yang* (2021, Oct.). Ultrasensitive and rapid COVID-19 tests for IgM, IgG, IgA and SARS-CoV-2 pseudovirus in clinical serological and saliva samples. 2021 International Conference on Smart Sensors (2021 ICSS), Taipei (Gather Town), Taiwan.

16. N.S. Li, Y.P. Hsu, H. W. Yang* (2020, Oct.). Development of Magnetic Immunoassay Platform for Rapid Cancer Biomarkers and Circulation Tumor Cells Detection. The 4th Global Conference on Biomedical Engineering & Annual Meeting on TSBME  (2020 GCBME), Taipei, Taiwan.

17. H.H. Pang, Y.C Ke, N.S. Li, Y.T. Chen, C.Y. Huang, K.C. Wei, H. W. Yang* (2020, Oct.). Gold-viral biomineralized nanozyme based lateral flow plasmonic biosensor (LFBP) for rapid intracellular glutathione (GSH) determination to predict GBM drug-resistance level. 2020 International Conference on Smart Sensors (2020 ICSS), Kaohsiung, Taiwan.

18. N.S. Li, Y.T Chen, Y.P Hsu, H.H Pang, Y.L Shiue, H. W. Yang* (2020, Oct.). Disposable enzyme-free µPAD-based biosensor for direct determination of uric acid in whole blood  using a smartphone. 2020 International Conference on Smart Sensors (2020 ICSS), Kaohsiung, Taiwan.

19. Y.P Hsu, N.S. Li, H. W. Yang* (2020, Oct.). A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone. 2020 International Conference on Smart Sensors (2020 ICSS), Kaohsiung, Taiwan.

20. Y.P Hsu, N.S. Li, Y.T Chen, H. W. Yang* (2020, Oct.). A Urological Point-of-care FXYD3 Test for Early Urothelial Carcinoma Screening and Postoperative Monitoring. 2020 International Conference on Smart Sensors (2020 ICSS), Kaohsiung, Taiwan.

21. N.S. Li, Y.T. Chen, Y.P. Hsu,  H. W. Yang* (2019, Jun.). A reusable enzyme-free biosensor based on mesoporous Prussian blue nanozyme functionalized PLA patch for rapid uric acid detection in serum. 6th International Conference on Bio-Sensing Technology, Kuala Lumpur, Malaysia.

22. Y.P. Hsu, N.S. Li, H. W. Yang* (2019, Jun.). A colorimetric biosensor based on antibody-conjugated Pt@Au nanozyme for simpler, faster, ultrasensitive Zika virus detection using smartphone. 6th International Conference on Bio-Sensing Technology, Kuala Lumpur, Malaysia.

23. N.S. Li, H.H. Pang, Y.P. Hsu,  H. W. Yang* (2019, Jun.). A Viral-Based Peroxidase-Like Gold Nano-Cluster Complex as Biosensor for Chemoresistance Prediction of Glioma Cells. 2019 International Conference on Smart Sensors (2019 ICSS), Hsinchu, Taiwan.

24. Y.P. Hsu, N.S. Li, H. W. Yang* (2019, Jun.) A colorimetric biosensor based on antibody-conjugated Pt@Au nanozyme for simpler, faster, ultrasensitive Zika virus detection using smartphone. 2019 International Conference on Smart Sensors (2019 ICSS), Hsinchu, Taiwan.

25. N.S. Li, Y.P. Hsu, Y.T. Chen, C. Peng, H.W. Yang* (2018, Jun). Magnetic liquid for rapid detection of CA19-9 and MUC1 in pancreatic cancer diagnosis. 28th Anniversary World Congress on Biosensors, Miami, USA.

26. Y.P. Hsu, N.S. Li, Y.T. Chen, C. Peng, S.T. Pang, H.W. Yang* (2018, Jun). A simple fabrication of biochip for home urothelial cancer diagnosis. 28th Anniversary World Congress on Biosensors, Miami, USA.

27. W. L. Hsu, N.S. Li, H.W. Yang*(2018, May). Disposable microneedle patch for colorimetric glucose biosensing. 5th International Conference on Microneedle, Vancouver, Canada.

28. N.S. Li, C. Peng, L. H. Pan, H.W. Yang* (2016, Dec). Magnetic Liquid-Based Biosensing for Early Pancreatic Cancer Diagnosis. 2016 2nd Global Nanotechnology Congress and Expo, Las Vegas, USA.