My interests are in the characterisation of proteinaceous self-assembling systems and the development of methods for doing this. Recently I have been framing this in the context of membrane interacting and remodelling proteins. I have a particular interest in cryo electron microscopy, light and X-ray scattering, single molecule and biophysical methods for structure determination.
The link between molecular architecture, assembly and macromolecular morphology is fascinating. Understanding structurally and mechanistically how multimerisation produces physiologically important assemblies develops our understanding of normal and pathological processes and will also advance our ability to manipulate and even design such systems.