The Department of Physiology is an important segment of the Faculty of Science, University of Karachi and occupies a very prominent place in the modern age of Biosciences, Clinical/Biomedical Sciences and other Applied Physiological Sciences.

This department, founded by Prof. Dr. M. H. Qazi, in 1964, was the first one outside medical colleges to introduce teaching and research programs in Basic and Experimental Physiology at the graduate and postgraduate levels. It initiated its academic and research programs with 3 teaching staff and 8 students to its present strength of 22 faculty members and 17 supporting staff members and more than 1000 students including both the Major and Minors. Several renowned Professors are the pioneer faculty members of the department and are presently serving on key posts in various organizations including The University of Karachi. The Vice Chancellor of the University of Karachi, Prof. Dr. Pirzada Qasim Raza Siddiqui also belongs to this department.

Today, this department is the only institute in the country which has produced M.Phils and Ph.Ds in various disciplines of Physiology over the past many years.