Strychnos melinoniana / Dobrudua

STRYCHNOS MELINONIANA - DEVIL'S DOER.

Dobrudua, devil's doer, devil doer, faiseur de diableries. 
Family Loganiaceae (Logania family).
Hardiness USDA zone 10 - 11.
Propagation Seeds and cuttings.
Culture party sun, moist soil, needs high humidity.

Deze plant wordt door bewoners van Suriname gebruikt als natuurlijke viagra. Een aftreksel van een stukje dobroedoewa in vermouth helpt om een langdurige erectie te krijgen. Een te grote dosis, kan een pijnlijke ervaring zijn. In het binnenland wordt dobroedoewa soms als straf gebruikt tegen verkrachters. Deze krijgen gedwongen een grote dosis van de stof te drinken, waardoor ze vaak een week tot tien dagen met een constante zeer pijnlijke erectie rondlopen. Herkenbaar voor de hele gemeenschap, aan de schandpaal genageld.

Overview
Dobrudua is a woody climbing liana, almost as large as a tree, from the Amazon rainforest. There are two varieties: the red and the white dobrudua indicating the color of the rough outer bark.
The leaves, with 1 (one) cm short petioles, have five head nerves standing in pairs attached to twigs and have a pointed top; the flowers are white and sweet aromatic smelling like roses. The fruit is a berry.
Dobrudua contains the alkaloid Melinonine A, a calabash-curare alkaloid.  Also: Melinonine G (flavopereirine), B, E, F, J, K, L, M.

The alkaloids act as adrenergic blocking agents, dilates blood vessels of the skin and mucous membranes and thereby lowering blood pressure.
It also increases reflex excitability in the sacral (lower) region of the spinal cord.
The phytochemicals block or stimulate the release of adrenaline at nerve endings at different parts of the body.
Researchers think that this action changes blood flow or the transmission of nerve impulses to genital tissues. 
Shamans in Suriname regard devil doer as a natural alternative for Viagra® it is also used in magic rituals by these shamans.

Suriname's traditional medicine
A solution in water is used for the general potency while a tincture (alcohol solution) is used as a very powerful aphrodisiac. 



Planta Med. 1983 Nov;49(11):158-61.
[Complementary study of cytotoxic activity of melinonine f.]. Bassleer R, Marnette JM, Wiliquet P, De Pauw-Gillet MC, Caprasse M, Angenot L.
Source
Service d'Histologie et Cytologie, Faculté de Médecine, Université de Liège, Belgique.
Abstract
The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA IN VITRO.


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