Silene sp. / Melandrium / Leimkrauter / Koekoeksbloem soorten

Weinig bekend over een medisch gebruik van de koekoeksbloemen. Toch 1 soort die bij prostaatklachten mogelijk te gebruiken is. Afwachten.

Asian J Androl. 2012 Mar;14(2):320-4. doi: 10.1038/aja.2011.166. Epub 2012 Jan 9.
Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats.
Lee MY1, Shin IS, Seo CS, Lee NH, Ha HK, Son JK, Shin HK.
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown aetiology characterized by prostatic enlargement coincident with distinct alterations in tissue histomorphology. Instead of therapeutic agents that can cause severe side effects, plant extracts are frequently used to treat BPH. In this study, we investigated whether the Melandrium firmum methanolic extract (MFME) improves BPH, using the testosterone propionate (TP)-induced BPH rat model. Castration was performed via the scrotal route under sodium pentobarbital anaesthesia. BPH in castrated rats was generated via daily subcutaneous injections of TP (3 mg kg(-1)) dissolved in corn oil, for 4 weeks. MFME was administered daily by oral gavage at a dose of 200 mg kg(-1) for 4 weeks, along with the TP injections. The control group received injections of corn oil subcutaneously. At the scheduled termination of the experiment, all rats were killed and their prostates weighed; the relative prostate weight (prostate/body weight ratio) was calculated, and histomorphological changes in the prostate were examined. Additionally, we measured the levels of testosterone and dihydrotestosterone (DHT) in the serum and the prostate. Experimentally induced BPH led to marked decreases in the relative prostate weight and the DHT levels in the serum and the prostate. Histologically, BPH was evident in the ventral lobe of the prostate, and MFME treatment suppressed the severity of the lesions. These results indicate that MFME effectively inhibits the development of BPH induced by testosterone in a rat model. Further studies will be needed to identify the compound(s) responsibility for inducing the protective effect against BPH and determine its mechanism of action.

Melandrium firmum Rohrbach is a biennial herbaceousplant widely distributed in Korea that is used to treat anuria,breast cancer, gonorrhea, and diseases of lactation (Perry,1980). The BuOH-soluble fraction from the MeOH extractwas hepatotoxic, prolonged hexobarbital-induced sleepingtime, elevated serum transaminase activity, and causedsevere histopathological changes in hepatic cells whenadministered intraperitoneally (Chang et al., 1989, Shin etal., 1985; Woo et al., 1981). During the course of our studieson bioactive constituents derived from Korean endemicspecies, we found that the hexane and BuOH fractions ofthis plant inhibited 5-lipoxygenase (5-LOX). This paperdescribes the isolation, identification, and biological activityof the compounds from this plant


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