Sequoiadendron giganteum Buchh. / Mammoetboom

Deze boom kan 100 tot 120 meter hoog en  enkele duizenden jaren oud worden. Zijn uiterlijk is massief, kegelvormig maar niet puntig, wel met een afgeronde top, vergelijkbaar met een opgerichte fallus. 
De sequoia is een nuttige aanvulling bij osteoporose. Door stimulatie van de osteoblastische activiteit (herstellende werking op het beenderweefsel), versterkt hij de broze botten (osteogenesis imperfecta, ziekte van Porak en Durante of ziekte van Lobstein) verantwoordelijk voor spontane fracturen. Hij verstevigt de fracturen door een betere mineralisatie. Hij helpt ook om pezen en ligamenten te versoepelen.
Zijn belangrijkste werking is echter op het zenuw- en klierstelsel. Wordt beschouwd als een mannelijk anti-verouderings middel. De sequoia is een seksueel tonicum, heeft invloed op de spermatogenese, stimuleert de immuniteit en remt de veroudering.
Sequoia is een specifiek middel  voor de prostaat (adenoma). 


Bioorg Med Chem Lett. 2005 Apr 15;15(8):2019-21.
Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens. Son KH, Oh HM, Choi SK, Han DC, Kwon BM.
Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 52 Uendong Yoosunggu Taejeon, 305-600 Republic of Korea.
Abstract
A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 microg/mL.



Bajpai VK, Yoon JI, Chul Kang S. Antioxidant and antidermatophytic activities of essential oil and extracts of Metasequoia glyptostroboides Miki ex Hu. [Journal Article, Research Support, Non-U.S. Gov't]  Food Chem Toxicol 2009 Jun; 47(6):1355-61.
This study was undertaken to assess the antioxidant and antidermatophytic potential of the essential oil and extracts (hexane, chloroform, ethyl acetate and methanol) of Metasequoia glyptostroboides Miki ex Hu. Antioxidant activity was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The free radical scavenging activities of the oil and ethyl acetate extract were found to be superior (IC(50)=9.1 and 14.24 microg/ml, respectively) as compared to butylatedhydroxyanisole (BHA), (IC(50)=18.27 microg/ml). Also the ethyl acetate extract revealed the highest phenolic contents (93.26 mg/g of dry wt) as compared to the other extracts. Further, oil (1250 microg/disc) and extracts (1750 microg/disc) revealed 35.33-67.66 and 18.0-53.3% antidermatophytic effect, respectively, along with their respective MIC values (62.5-500 and 250-4000 microg/ml) against Trichophyton rubrum KCTC 6345, T. rubrum KCTC 6375, T. rubrum KCTC 6352, T. mentagrophytes KCTC 6085, T. mentagrophytes KCTC 6077, T. mentagrophytes KCTC 6316, Microsporum canis KCTC 6591, M. canis KCTC 6348 and M. canis KCTC 6349. The oil also had a strong detrimental effect on spore germination as well as concentration and time-dependent kinetic inhibition of M. canis KCTC 6591.



Stierle DB, Stierle AA, Bugni T. Sequoiamonascins a-d: novel anticancer metabolites isolated from a redwood endophyte. [Journal Article, Research Support, U.S. Gov't, Non-P.H.S.]
J Org Chem 2003 Jun 13; 68(12):4966-9.
Aspergillus parasiticus, a fungal isolate from the bark of a redwood tree (Sequoia sempervirens), has been shown to produce the antitumor metabolites sequoiatones A and B and more recently the sequoiatones C-F. We have also isolated another series of compounds with a new carbon skeleton, the sequoiamonascins. The structures of sequoiamonascins A-D were deduced by interpretation of their spectral data and that of some reaction products. The sequoiamonascins were isolated by brine shrimp lethality-guided fractionation and were submitted to the NCI for anticancer evaluation.


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