Lepidium sativum / Tuinkers / Garden cress

Ethnopharmacology of Lepidium Sativum Linn  (Brassicaceae): A Review 
Divanji Manohar, G.L.Viswanatha, S.Nagesh, Vishal Jain, H.N.Shivaprasad

ABSTRACT 
Lepidium sativum (Garden cress, Brassicaceae) is a fast-growing, edible  herb that is botanically related to  watercress and mustard, sharing their peppery, tangy flavor and aroma. In traditional system of Indian medicine  various parts of plant have been used to treat various human ailments such as diarrhea, dysentery, leprosy, skin  and eye diseases, leucorrhoea, scurvy, liver diseases, renal diseases, dyspepsia, asthma, cough, cold and seminal  weakness, also it is considered as bitter, diuretic, tonic, abortifacient, aphrodisiac, thermogenic, galactagogue,  emmenagogue, depurative, ophthalmic, also used to treat tenesmus, secondary syphilis. 
 Lepidium sativum mainly contains alkaloids, saponins, anthracene glycosides, carbohydrates, proteins, amino acids, flavonoids,  sterols as chief phytochemical constituents. Glutamic acid is the most abundant amino acid; leucine and  methionine are the highest and the lowest essential amino acids respectively. Its extracts have been found to  possess various pharmacologicalivities. A comprehensive review of its ethno-medical uses, chemical 
constituents and pharmacological profile as a medicinal plant.  Mainly focused on its Anti-inflammatory,  antipyretic, analgesic and coagulant, antihypertensive, diuretic anti-diabetic, hepatoprotective, anti-ashthamatic,  prokinetic, laxative, hypercholesterolemic, fracture healing, chemo-protective and anti-oxidant activity for  better evaluation in various therapeutic applications. 

Anti-oxidant activity 
Ethanolic extract of Lipidum sativum seeds showed a potential nephrocurative,  nephroprotectivity and  invivo antioxidant potential at 200mg/kg and 400mg/kg  against Cisplatin(5mg/kg, i.p) induced  nephrotoxicity. The enzyme estimation in 
Kidney tissue found that increased in  malondialdehyde, superoxidedimutase, catalase and reduced glutathione level 
Yogesh chand Y, Srivastav DN, Seth  AK, Vipin S, Balaraman R, Tejas KG.  Invivo antioxidant potential of  Lepidium sativum  L. seeds in albino 
rats using cisplatin induced  nephrotoxicity. Inter J  Phytomed  2010; 2: 292-298


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