Carex pendula e.a. / Zegge hangende

Carex pendula (pendulous sedge, also known as hanging, drooping or weeping sedge) is a large sedge of the genus Carex. It occurs in woodland, scrubland, hedges and beside streams, preferring damp, heavy clay soils. It is sometimes grown as a garden plant because of its distinctive appearance.
It is native to western, central and southern parts of Europe occurring north to Sweden, Denmark and parts of Scotland where it reaches 58°N. It is also found in north-west Africa, the Azores, Madeira and parts of the Middle East.


Phytochemistry. 2001 Jun;57(3):393-400. Identification and ecdysteroid antagonist activity of three oligostilbenes from the seeds of Carex pendula (Cyperaceae).Meng Y1, Bourne PC, Whiting P, Sik V, Dinan L.
Methanolic extracts of seeds of several (Carex species were found to antagonise the action of 20-hydroxyecdysone in the Drosophila melanogaster microplate-based B(II) cell bioassay. Bioassay-guided HPLC analysis of seeds of Carex pendula (drooping sedge) provided one previously unknown tetrastilbene (cis-miyabenol A) and two known oligostilbenes (kobophenol B and cis-miyabenol C) as the biologically active compounds (EC50 values were 31, 37 and 19 microM, respectively, vs. 5 x 10(-8) M 20-hydroxyecdysone). The structures and relative stereochemistries of these compounds were deduced by comprehensive ID- and 2D-NMR experiments. These compounds are isolated from Carex pendula for the first time. In vitro experiments with dipteran and lepidopteran ecdysteroid receptor proteins demonstrate that the oligostilbenes are able to compete with radiolabelled ecdysteroid ([3H]ponasterone A) for occupancy of the ligand binding site. IC50/Ki values are similar to the EC50 values obtained in the B(II) bioassay.



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