Buddleja species / Vlinderstruik

De vlinderstruik, ook herfstsering genoemd, bloeit vanaf begin juli. De zoetgeurende, lila, rode, witte of gele bloemaren lokken vooral vlinders (koolwitje, citroenvlinder, kleine en grote vos, atalanta), maar ook andere insecten aan.  Het is een (meestal) bladverliezende heester die zich in iedere tuin thuis voelt. Hij kan 3 m hoog worden. 
Inheems is de vlinderstruik, afhankelijk van de soort, in China, Zuid-Afrika, Himalaja, maar ook in Chili, Argentinië, Peru en delen van Noord-Amerika. Hij groeit daar op stenige stranden langs rivieren, in wegbermen en struikgewas, op hellingen en in houtwallen. Er zijn ook groenblijvende soorten. 

Buddleia officinalis is an evergreen Shrub growing to 2 m (6ft 7in).  It is hardy to zone 8. It is in leaf 12-Jan It is in flower from Dec to February. The flowers are dioecious (individual flowers are either male or female, but only one sex is to be found on any one plant so both male and female plants must be grown if seed is required) and are pollinated by Bees, lepidoptera.The plant is not self-fertile. 

The plant prefers light (sandy), medium (loamy) and heavy (clay) soils, requires well-drained soil and can grow in nutritionally poor soil.The plant prefers acid, neutral and basic (alkaline) soils. and can grow in very alkaline soils.
It cannot grow in the shade.It requires dry or moist soil and can tolerate drought.It can tolerate atmospheric pollution.

Medicinal Uses
Antispasmodic;  Febrifuge;  Ophthalmic.

Febrifuge. The flowers and flower buds are antispasmodic, slightly cholagogue and ophthalmic. They have an action similar to vitamin P, reducing the permeability and fragility of the blood vessels of the skin and small intestine. They are used in the treatment of various eye problems. They are also used in the treatment of gonorrhoea, hepatitis and hernia. A decoction of the leaves is used in the treatment of collyrium. Also used in the treatment of gonorrhoea, hepatitis and hernia.

http://kruidwis.blogspot.com/2011/01/planten-op-papier-buddleja-globosa.html

Wetenschappelijk onderzoek

Z Naturforsch C. 2009 Jan-Feb;64(1-2):11-9. Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour. El-Domiaty MM, Wink M, Abdel Aal MM, Abou-Hashem MM, Abd-Alla RH.Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Abstract
A new natural compound, named 6-O-(3",4"-dimethoxycinnamoyl) catalpol, was isolated from the defatted alcoholic extract of the flowering parts of Buddleja asiatica Lour. (family Scrophulariaceae). Other separated known compounds included steroids (beta-sitosterol, stigmasterol, stigmasterol-O-glucoside, beta-sitosterol-O-glucoside), iridoid glucosides (methyl catalpol, catalpol, aucubin), phenylpropanoids (isoacteoside and acteoside), a triterpene saponin (mimengoside A), flavonoids (diosmin and linarin) in addition to the free sugars mannitol and sucrose. The structures of the isolated compounds were established by 1H and 13C NMR and mass spectrometry. Furthermore, the polar fraction of the flowering parts and the roots showed substantial antihepatotoxic activity comparable to that of the lignan silymarin.

Am J Chin Med. 2010;38(3):585-98. Anti-Inflammatory effect of Buddleja officinalis on vascular inflammation in human umbilical vein endothelial cells. Lee YJ, Moon MK, Hwang SM, Yoon JJ, Lee SM, Seo KS, Kim JS, Kang DG, Lee HS.
Abstract
Vascular inflammation process has been suggested to be an important risk factor in the initiation and development of atherosclerosis. In this study, we investigated whether and by what mechanisms an aqueous extract of Buddleja officinalis (ABO) inhibited the expressions of cellular adhesion molecules, which are relevant to inflammation and atherosclerosis. Pretreatment of human umbilical vein endothelial cells (HUVEC) with ABO (1-10 microg/ml) for 18 hours dose-dependently inhibited TNF-alpha-induced adhesion U937 monocytic cells, as well as mRNA and protein expressions of vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1). Pretreatment with ABO also blocked TNF-alpha-induced ROS formation. Nuclear factor-kappa B (NF-kappaB) is required in the transcription of these adhesion molecule genes. Western blot analysis revealed that ABO inhibits the translocation of the p65 subunit of NF-kappaB to the nucleus. ABO inhibited the TNF-alpha-induced degradation of IkappaB-alpha, an inhibitor of NF-kappaB, by inhibiting the phosphorylation of IkappaB-alpha in HUVEC. Taken together, ABO could reduce cytokine-induced endothelial adhesiveness throughout down-regulating intracellular ROS production, NF-kappaB, and adhesion molecule expression in HUVEC, suggesting that the natural herb Buddleja officinalis may have potential implications in atherosclerosis.

Cell Immunol. 2011;268(2):112-6. Epub 2011 Feb 19. Linarin isolated from Buddleja officinalis prevents hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells. Kim YH, Lee YS, Choi EM.
Abstract
The flowers and leaves buds of Buddleja officinalis MAXIM (Buddlejaceae) are used to treat eye troubles, hernia, gonorrhea and liver troubles in Asia. To elucidate the protective effects of linarin isolated from B. officinalis on the response of osteoblast to oxidative stress, osteoblastic MC3T3-E1 cells were pre-incubated with linarin for 1h before treatment with 0.3mM H(2)O(2) for 48h, and markers of osteoblast function and oxidative damage were examined. Linarin significantly (P<0.05) increased cell survival, alkaline phosphatase (ALP) activity, collagen content, calcium deposition, and osteocalcin secretion and decreased the production of receptor activator of nuclear factor-kB ligand (RANKL), protein carbonyl (PCO), and malondialdehyde (MDA) of osteoblastic MC3T3-E1 cells in the presence of hydrogen peroxide. These results demonstrate that linarin can protect osteoblasts against hydrogen peroxide-induced osteoblastic dysfunction and may exert anti-resorptive actions, at least in part, via the reduction of RANKL and oxidative damage.

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