While we conventionally think of genomic DNA as a simple polymer of A's, C's, G's, and T's, the chemistry of the genome is in fact far more interesting.

Our laboratory focuses on the DNA modifying enzymes that provide an added layer of complexity to the genome. These enzymes can be involved in the purposeful introduction of mutations or in the chemical modification of nucleobases, making DNA into a remarkably dynamic entity. Many of these processes are at the heart of the battle between the immune system and pathogens.

We utilize a broad array of approaches, which include 1) biochemical characterization of enzyme mechanisms, 2) chemical synthesis of enzyme probes, and 3) biological assays spanning bacteriology, immunology, and virology to study DNA modifying enzymes.

Our research program aims to understand, harness and perturb these diversity generating pathways.

Lab News

  • Welcome, Izzy Culyba! We welcome our newest lab baby, Isabel (Izzy) Culyba! Congrats to Ali and Matt! And a special congratulations to Maddy on becoming a big sister!
    Posted Nov 13, 2016, 6:48 AM by Kohli Lab
  • Dr. Monica Liu Congratulations to Monica for a successful defense of her dissertation entitled "Deciphering the TETrad of Epigenetic Cytosine Modifications". Keep up the strong work in medical school and beyond!
    Posted Nov 9, 2016, 7:43 AM by Kohli Lab
  • Dr. Charlie Mo Congratulations to Charlie for a successful defense of his thesis work, "Making Antibiotics Great Again". Best of luck in your post-doc!
    Posted Sep 26, 2016, 11:19 AM by Kohli Lab
  • Matt wins the Robert Austrian Fellow Teaching Award! Way to be a great teacher, Matt!
    Posted Jun 11, 2015, 7:20 AM by Kohli Lab
  • Rahul receives an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund See the announcement here: http://www.bwfund.org/newsroom/announcements/bwf-commits-225-million-advancing-biomedical-research-0Thanks, BWF!
    Posted Jul 7, 2016, 6:33 PM by Kohli Lab
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