While we conventionally think of genomic DNA as a simple polymer of A's, C's, G's, and T's, the chemistry of the genome is in fact far more interesting.

Our laboratory focuses on the DNA modifying enzymes that provide an added layer of complexity to the genome. These enzymes can be involved in the purposeful introduction of mutations or in the chemical modification of nucleobases, making DNA into a remarkably dynamic entity. Many of these processes are at the heart of the battle between the immune system and pathogens.

We utilize a broad array of approaches, which include 1) biochemical characterization of enzyme mechanisms, 2) chemical synthesis of enzyme probes, and 3) biological assays spanning bacteriology, immunology, and virology to study DNA modifying enzymes.

Our research program aims to understand, harness and perturb these diversity generating pathways.

Lab News

  • Kohli lab finishes strong in Micro March Madness Tournament! The Kohli lab came in a respectable 2nd out of 25 labs in the 22nd Annual Micro March Madness Tournament! Check out the photos here. Special thanks to Jeff Kubiak ...
    Posted Apr 16, 2014, 7:22 AM by Kohli Lab
  • Charlie is featured on LabTV Check out the video here:
    Posted Apr 5, 2014, 11:43 AM by Kohli Lab
  • Emily wins the NSF Fellowship! Emily has won the NSF Graduate Fellowship! Congratulations, Emily! Here's a song for you: 
    Posted Apr 1, 2014, 2:30 PM by Kohli Lab
  • Welcome, new rotation students! We warmly welcome rotation students Jamie DeNizio (BMB) and Amanda Samuels (MVP, VMD-PhD) into the lab! 
    Posted Feb 20, 2014, 9:26 PM by Kohli Lab
  • Welcome, Jessie "Sie Sie" Crawford! We welcome the latest lab baby, Jessie Crawford! Congrats, Hiu-Fai and Danny!
    Posted Feb 20, 2014, 9:27 PM by Kohli Lab
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