The picture above describes the main theme of my research. 

...Noise in biological systems

    ...Synthetic biology (gene regulatory networks)

        ...Systems biology (complex biological networks)

            ...E.coli experiments


I am interested in identifying patterns from noisy data via stochastic (probability+dynamic) modeling and statistical analysis. I have been investigating the stochastic properties of gene regulatory systems by engineering E. coli cells. I have also been exploiting the stochasticity to design novel cellular functions. I have a full spectrum of experience in standard molecular biology techniques, single-cell-level experiment, mathematical modeling, and computational and analytical analysis for biological systems.

My current field of interest is systems and synthetic biology in the mathematical, computational and experimental aspects. In recent years, genetic regulatory systems have been synthetically designed and implemented for both basic research and specific application. There are many important issues that need to be addressed with respect to reengineering cellular functions, such as stochasticity, modularity, stability, and scalability. To overcome these issues, I have been pursuing my research. 

During my doctoral studies, I conducted mathematical and computational (Monte-Carlo simulations) analyses on non-equilibrium stochastic processes under the direction of both Prof. den Nijs (Physics, University of Washington) and Prof. Qian (Applied Mathematics, University of Washington). I was trained to be a mathematical modeler and analyst. 

In my post-doctoral research, my main effort was investigating stochastic biological networks with regard to modularity, stochasticity and nonlinearity, by using my inter-disciplinary background knowledge and skills developed in physics and applied mathematics. I took a leading role in supporting computational and mathematical research conducted by the group of Prof. Herbert Sauro (UW Bioengineering), in particular, focusing on synthetic network design and analysis. 

Currently as an acting assistant professor I have been experimentally verifying these theoretical results that I obtained in my post-doctoral study, by re-engineering E. coli cells. 

My theoretical studies were supported under an NSF grant in Theoretical Biology ($660K; 2008-2012; PI: Sauro) and the theories are currently under an experimental verification process with another NSF grant awarded from the Molecular and Cellular Biosciences program ($546K; 2012-2015; PI: Sauro). For both the grants, I wrote the main research plans.


 Office: N410B, William H. Foege Building [UW map]
 Phone: (206) 543-8321
 Address: Department of Bioengineering
University of Washington at Seattle
William H. Foege Building
Box 355061 1705 NE Pacific St. Seattle, WA 98195-5061