Publications

Primary Literature

2014


Dubé, M., Rey, F.A., and Kielian, M. (2014) "Rubella virus: first calcium-requiring viral fusion protein." PLoS Pathog. 10(12): e1004530.

Zheng, A., Yuan, F., Kleinfelter, L.M., and Kielian, M. (2014) "A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins.Nat. Commun. 5:3877.

Martinez, M.G., Snapp, E.L., Perumal, G.S.
, Macaluso, F.P., and Kielian, M. (2014) "Imaging the Alphavirus Exit Pathway.J. Virol. 88(12):6922-33. [Selected for cover.] 

2013

Ooi, Y.S.*, Stiles, K.M.*, Liu, C.Y.*, Taylor, G.M., and Kielian, M. (2013) "Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry.." PLoS Pathog. 9(12): e1003835. *These authors contributed equally to this work.

Uchime, O.*, Fields, W.*, and Kielian, M. (2013) "The role of E3 in pH protection during Alphavirus assembly and exit." J. Virol. 87(18):10255-62. *These authors contributed equally to this work.
  
Zheng, Y. and Kielian, M. (2013) "Imaging of the Alphavirus capsid protein during virus replication." J. Virol. 87(17):9579-89.

Sánchez-San Martín, C.,
Nanda, S., Zheng, Y., Fields, W., and Kielian, M. (2013) "Cross-inhibition of chikungunya virus fusion and infection by alphavirus E1 domain III proteins.J. Virol. 87(13):7680-7.

Fields, W. and Kielian, M. (2013) "
A Key Interaction between the Alphavirus Envelope Proteins Responsible for Initial Dimer Dissociation during Fusion." J. Virol. 87(7):3774-81.


2012


2011

Roman-Sosa, G. and Kielian, M. (2011) "The interaction of Alphavirus E1 protein with exogenous domain III defines stages in virus-membrane fusion." J. Virol. 85(23):12271-9

Zheng, Y., Sánchez-San Martín, C., Qin, Z., and Kielian, M. (2011) "The Domain I-Domain III linker plays an important role in the fusogenic conformational change of the Alphavirus membrane fusion protein." J. Virol. 85(13):6334-42[Selected for highlight by editors.] 

2010

Zheng, A., Umashankar, M., and Kielian, M. (2010) "In vitro and in vivo studies identify important features of Dengue virus pr-E protein interactions." PLoS Pathog. 6(10):e1001157

Liu, C.Y.,
Besanceney, C., Song, Y., and Kielian, M. (2010) "Pseudorevertants of Semliki forest virus fusion-block mutation reveal a critical interchain interaction in the core trimer." J. Virol. 84(22):11624-33. 

Liao, M., 
Sánchez-San Martín, C., Zheng, A., and Kielian, M. (2010) "In vitro reconstitution reveals key intermediate states of trimer formation by the dengue virus membrane fusion protein." J. Virol. 84(11):5730-40


2009

Sánchez-San Martín, C., Sosa, H., and Kielian, M. (2008) "A stable prefusion intermediate of the alphavirus fusion protein reveals critical features of class II membrane fusion." Cell Host Microbe 4(6):600-8. 

Umashankar, M., Sánchez San Martín, C., Liao, M., Reilly, B., Guo, A., Taylor, G., and Kielian, M. (2008) "Differential cholesterol binding by class II fusion proteins determines membrane fusion properties." J. Virol. 82(18):9245-53. 

2007

Taylor, G.M., Hanson, P.I., and Kielian, M. (2007). "Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding." J. Virol. 81(24):13631-9. 

Markosyan, R.M., Kielian, M., and Cohen, F.S. (2007) "Fusion induced by a class II viral fusion protein, semliki forest virus E1, is dependent on the voltage of the target cell.J. Virol. 81(20):11218-25.

2005

Liao, M. and Kielian, M. (2005) “Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus-membrane fusion.J. Cell Biol. 171(1):111-20. 


2004



Gibbons, D.L., Reilly, B., Ahn, A., Vaney, M.C., Vigouroux, A., Rey, F.A., and Kielian, M. (2004) "Purification and crystallization reveal two types of interactions of the fusion protein homotrimer of Semliki Forest virus.J. Virol. 78(7):3514-23.

Gibbons, D.L., Ahn, A., Liao, M., Hammar, L., Cheng, R.H., and Kielian, M. (2004) "Multistep regulation of membrane insertion of the fusion peptide of Semliki Forest virus.J. Virol. 78(7):3312-8.

Gibbons, D.L., Vaney, M.C., Roussel, A., Vigouroux, A., Reilly, B., Lepault, J., Kielian, M., and Rey, F.A. (2004) “Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus.” Nature 427(6972): 320-5.  

2003

Gibbons, D.L., Erk, I., Reilly, B., Navaza, J., Kielian, M., Rey, F.A., and Lepault, J. (2003) "Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography.Cell 114(5):573-83.

Zhang, X., Fugère, M., Day, R., and Kielian, M. (2003) "Furin processing and proteolytic activation of Semliki Forest virus.J. Virol. 77(5):2981-9.

2002

Chatterjee, P.K., Eng, C.H., and Kielian, M. (2002) "Novel mutations that control the sphingolipid and cholesterol dependence of the Semliki Forest virus fusion protein.J. Virol. 76(24):12712-22.

Samsonov, A.V., Chatterjee, P.K., Razinkov, V.I., Eng, C.H., Kielian, M., and Cohen, F.S. (2002) "Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus.J. Virol. 76(24):12691-702.

Ahn, A., Gibbons, D.L., and Kielian, M. (2002) "The fusion peptide of Semliki Forest virus associates with sterol-rich membrane domains.J. Virol. 76(7):3267-75.


2001

Lu, Y.E., Eng, C.H., Shome, S.G., and Kielian, M. (2001) "In vivo generation and characterization of a soluble form of the Semliki forest virus fusion protein.J. Virol. 75(17):8329-39.


2000

Gibbons, D.L., Ahn, A., Chatterjee, P.K., and Kielian, M. (2000) " Formation and characterization of the trimeric form of the fusion protein of Semliki Forest Virus.J. Virol. 74(17):7772-80.

Lu, Y.E. and Kielian, M. (2000). "Semliki forest virus budding: assay, mechanisms, and cholesterol requirement.J. Virol. 74(17):7708-19.

Kielian, M., Chatterjee, P.K., Gibbons, D.L., and Lu, Y.E. (2000). "Specific roles for lipids in virus fusion and exit. Examples from the alphaviruses.Subcell. Biochem. 34:409-55.

Chatterjee, P.K., Vashishtha, M., and Kielian, M. (2000). "Biochemical consequences of a mutation that controls the cholesterol dependence of Semliki Forest virus fusion.J. Virol. 74(4):1623-31.

1999-1977



Reviews

Kielian, M. (2014) "Mechanisms of Virus Membrane Fusion Proteins." Annu. Rev. Virol. 1:171-89.

Pie
rson, T.C. and Kielian, M. (2013) "Flaviviruses: braking the entering." Curr. Opin. Virol. 3(1):3-12.

Kielian, M., Chanel-Vos, C., and Liao, M. (2010) “Alphavirus Entry and Membrane Fusion.” Viruses 2(4):796-825.

Sánchez-San Martín, C., Liu, C.Y., and Kielian, M. (2009) "Dealing with low pH: entry and exit of alphaviruses and flaviviruses." Trends Microbiol. 17(11):514-21. 

Kielian, M. (2006) “Class II virus membrane fusion proteins.” Virology 344(1):38-47.  

Kielian, M. and Rey, F.A. (2006) “Virus membrane fusion proteins: more than one way to make a hairpin.” Nat. Rev. Microbiol. 4(1):67-76.  



Previews

Stiles, K.M. and Kielian, M. (2011) "Alphavirus Entry: NRAMP Leads the Way.Cell Host Microbe 10(2):92-3.

Kielian, M. (2010) “Structural biology: An alphavirus puzzle solved.” Nature 468(7324):645-6.  

Kielian, M. (2002) "Structural surprises from the flaviviruses and alphaviruses.Mol. Cell. 9(3):454-6.


Collaborations

Vigant, F., Lee, J., Hollmann, A., Tanner, L.B., Akyol Ataman, Z., Yun, T., Shui, G., Aguilar, H.C., Zhang, D., Meriwether, D., Roman-Sosa, G., Robinson, L.R., Juelich, T.L., Buczkowski, H., Chou, S., Castanho, M.A., Wolf, M.C., Smith, J.K., Banyard, A., Kielian, M., Reddy, S., Wenk, M.R., Selke, M., Santos, N.C., Freiberg, A.N., Jung, M.E., and Lee, B. (2013) "A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion.PLoS Pathog. 9(4):e1003297.



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