VIRUS ENTRY AND EXIT
Margaret Kielian, Ph.D.
Samuel H. Golding Chair in Microbiology
Professor, Department of Cell Biology
Albert Einstein College of Medicine,
Room 515, Chanin Building
1300 Morris Park Avenue, Bronx, New York, 10461
Phone: (718) 430-3638
Fax: (718) 430-8574
Our lab works on the entry and exit pathways of enveloped (membrane-coated) viruses in their host cells. All enveloped viruses use membrane fusion to infect a cell, and membrane budding to produce new viruses. Studying these entry and exit processes helps us to understand the mechanisms of virus infection and to develop new antiviral therapies, and also provides a key model for cellular membrane fusion and budding reactions. Our research focuses primarily on alphaviruses and flaviviruses, virus groups that include important human pathogens such as dengue, West Nile, and yellow fever viruses.
Graduate students and MD/Ph.D. students are welcome to join our lab!
You will gain experience in a wide variety of methods in virology, molecular biology, cell biology, protein biochemistry (such as selection and analysis of virus mutants, in vitro mutagenesis, PCR, cloning, cell culture, immunofluorescence, electron microscopy, pulse-chase analysis, protein expression, purification and analysis, membrane fusion assays, fluorescence spectroscopy, structural biology…..).
You will learn about important questions in virus and cell biology, protein trafficking, protein-membrane interactions, virus structure and how it controls virus biology…..
Click on the links to learn more about our research, papers, and training in the Kielian lab.
Last updated: 02-11-2014 by Yaw Shin