Our lab works on the entry and exit pathways of enveloped (membrane-coated) viruses in their host cells. All enveloped viruses use membrane fusion to infect a cell, and membrane budding to produce new viruses. Studying these entry and exit processes helps us to understand the mechanisms of virus infection and to develop new antiviral therapies, and also provides a key model for cellular membrane fusion and budding reactions. Our research focuses primarily on alphaviruses and flaviviruses, virus groups that include important human pathogens such as dengue, West Nile, and yellow fever viruses. 

Click on the links above
to learn more about our research, papers, and training in the Kielian lab.

Recent News:

* We published a new review: Brown, R. B., Wan, J. J., and Kielian, M. (2018) "The alphavirus exit pathway: What we know and what we wish we knew." Viruses 10(2), 89: doi:10.3390 / v10020089.

* Welcome our new lab technician, Matthew Angeliadis!

* Congratulations to Dr. Emily Byrd on her publication in mBio: Byrd, E. A. and Kielian, M. (2017) "An alphavirus E2 membrane-proximal domain promotes envelope protein lateral interactions and virus budding." mBio 8(6):e01564-17.

* Congratulations to Dr. Emily Byrd for successfully defending her thesis!