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VIRUS ENTRY AND EXIT










Our lab works on the entry and exit pathways of enveloped (membrane-coated) viruses in their host cells. All enveloped viruses use membrane fusion to infect a cell, and membrane budding to produce new viruses. Studying these entry and exit processes helps us to understand the mechanisms of virus infection and to develop new antiviral therapies, and also provides a key model for cellular membrane fusion and budding reactions. Our research focuses primarily on alphaviruses and flaviviruses, virus groups that include important human pathogens such as dengue, West Nile, and yellow fever viruses. 



Click on the links above
to learn more about our research, papers, and training in the Kielian lab.
 

Recent News:

* Congratulations to Dr. Maria Guadalupe Martinez on her publication in PLOS Pathogens:
Martinez, M. G. and Kielian, M. (2016) "Intercellular extensions are induced by the alphavirus structural proteins and mediate virus transmission." PLOS Pathog 12(12):e1006061.


* Congratulations to Dr. Rebecca Brown, who has been awarded a Ruth L. Kirschstein NRSA F32 Postdoctoral Fellowship from the NIH!

* Welcome Ph.D. student Jen Kimble, Fulbright fellow 
Dr. Mariano Prado Acosta, and Postdoctoral fellow Dr. Eileen Geoghegan to the lab!

* Publication:
Dubé, M., Etienne, L., Fels, M., Kielian, M. (2016) "Calcium-dependent Rubella virus fusion occurs in early endosomes." J Virol 90(14):6303-13.


* Publication: 
Stiles, K. M. and Kielian, M. (2016) "Role of TSPAN9 in alphavirus entry and early endosomes." J Virol 90(9):4289-97.