Our lab works on the entry and exit pathways of enveloped (membrane-coated) viruses in their host cells. All enveloped viruses use membrane fusion to infect a cell, and membrane budding to produce new viruses. Studying these entry and exit processes helps us to understand the mechanisms of virus infection and to develop new antiviral therapies, and also provides a key model for cellular membrane fusion and budding reactions. Our research focuses primarily on alphaviruses and flaviviruses, virus groups that include important human pathogens such as dengue, West Nile, and yellow fever viruses. 

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to learn more about our research, papers, and training in the Kielian lab.

Recent News:

* Publication: 
Fields, W. and Kielian, M. (2015) "Interactions involved in pH protection of the alphavirus fusion protein." Virology 486:173-9.

* Publication:
Zheng, Y. and Kielian M. (2015) "An alphavirus temperature-sensitive capsid mutant reveals stages of nucleocapsid assembly." Virology 484:412-20.

* Publication:
Ooi, Y.S., Dubé, M., and Kielian, M. (2015) "BST2/Tetherin inhibition of alphavirus exit." Viruses 7(4):2147-67.