Homepage of Kathy Dujardin, PhD

Position

- Professor of Clinical Neuroscience at the University of Lille (Lille 2 - Droit et Santé, Medicine), Inserm U1171
- Neuropsychology specialist, Neurology and Movement Disorders Department, Lille University Medical Center (CHU Lille) 
- Program Director, Master degree in Biology and Health Sciences, University of Lille (in 
charge of the health sector) http://master-biologie-sante.univ-lille.fr/
- Deputy director of the VASCOG Hospital-University Federation, in charge of education  
- Member of the Lille Centre of Excellence in Neurodegenerative Disorders board, LiCEND 

Interests

My work is focused on the cognitive and behavioral functions of the basal ganglia. I have clinical and research expertise on cognitive (attention and executive functions) and behavioral (apathy, anxiety, impulse control disorders) dysfunctions related to Parkinson's disease and other basal ganglia disorders.

Publications in the last five years

2018


Mulders AEP, Moonen AJH, Dujardin K, Kuijf ML, Duits A, Flinois B, Handels RLH, Lopes R, Leentjens AFG. Cognitive behavioural therapy for anxiety disorders in Parkinson's disease: Design of a randomised controlled trial to assess clinical effectiveness and changes in cerebral connectivity. J Psychosom Res. 2018 Sep;112:32-39.

Robert P, Lanctôt KL, Agüera-Ortiz L, Aalten P, Bremond F, Defrancesco M, Hanon C, David R, Dubois B,Dujardin K, Husain M, König A, Levy R, Mantua V, Meulien D, Miller D, Moebius HJ, Rasmussen J, Robert G, Ruthirakuhan M, Stella F, Yesavage J, Zeghari R, Manera V. Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group. Eur Psychiatry. 2018 Aug 17;54:71-76.

Baille G, Chenivesse C, Perez T, Machuron F, Dujardin K, Devos D, Defebvre L, Moreau C.Dyspnea: An underestimated symptom in Parkinson's disease. Parkinsonism Relat Disord. 2018 Sep 8.

Betrouni N, Delval A, Chaton L, Defebvre L, Duits A, Moonen A, Leentjens AFG, Dujardin K. Electroencephalography-based machine learning for cognitive profiling in Parkinson's disease: Preliminary results. Mov Disord. 2018 Oct 21. doi: 10.1002/mds.27528.

Delval A, Braquet A, Dirhoussi N, Bayot M, Derambure P, Defebvre L, Tard C, Dujardin K. Motor Preparation of Step Initiation: Error-related Cortical Oscillations. Neuroscience. 2018 Oct 10;393:12-23.

Bayot M, Dujardin K, Tard C, Defebvre L, Bonnet CT, Allart E, Delval A. The interaction between cognition and motor control: A theoretical framework for dual-task interference effects on posture, gait initiation, gait and turning. Neurophysiol Clin. 2018 Dec;48(6):361-375.


2017

Lopes R, Delmaire C, Defebvre L, Moonen AJ, Duits AA, Hofman P, Leentjens AF, Dujardin K. Cognitive phenotypes in parkinson's disease differ in terms of brain-network organization and connectivity. Hum Brain Mapp. 2017 Mar;38(3):1604-1621.

Hassan M, Chaton L, Benquet P, Delval A, Leroy C, Plomhause L, Moonen AJ, Duits AA, Leentjens AF, van Kranen-Mastenbroek V, Defebvre L, Derambure P, Wendling F, Dujardin K. Functional connectivity disruptions correlate with cognitive phenotypes in Parkinson's disease. Neuroimage Clin. 2017 Mar 6;14:591-601. 10.1016/j.nicl.2017.03.002

Moonen AJH, Wijers A, Dujardin K, Leentjens AFG. Neurobiological correlates of emotional processing in Parkinson's disease: A systematic review of experimental studies. J Psychosom Res. 2017 Sep;100:65-76.

Huin V, Strubi-Vuillaume I, Dujardin K, Brion M, Delliaux M, Dellacherie D, Cuvellier JC, Cuisset JM, Riquet A, Moreau C, Defebvre L, Sablonnière B, Devos D. Expanding the phenotype of SCA19/22: Parkinsonism, cognitive impairment and epilepsy. Parkinsonism Relat Disord. 2017 Dec;45:85-89.

2016

Tard C, Dujardin K, Girard A, Debaughrien M, Derambure P, Defebvre L, Delval A. How does visuospatial attention modulate motor preparation during gait initiation? Exp Brain Res. 2016;234(1):39-50.

Rieu I, Houeto JL, Pereira B, De Chazeron I, Bichon A, Chéreau I, Ulla M, Brefel-Courbon C, Ory-Magne F, Dujardin K, Tison F, Krack P, Durif F. Impact of Mood and Behavioral Disorders on Quality of Life in Parkinson's disease. J Parkinsons Dis. 2016 Mar 11;6(1):267-77.

Broen MP, Köhler S, Moonen AJ, Kuijf ML, Dujardin K, Marsh L, Richard IH, Starkstein SE, Martinez-Martin P, Leentjens AF. Modeling anxiety in Parkinson's disease. Mov Disord. 2016 Mar;31(3):310-6.

Leroy A, Roche J, Dujardin K, Duthoit D, Puisieux F, Pins D, Jardri R, Boulanger E. Hallucinations and Parkinson's disease in the elderly: Pitfalls and medical care. Presse Med. 2016;45(5):522-31.

Annic A, Bourriez JL, Delval A, Bocquillon P, Trubert C, Derambure P, Dujardin K. Effects of Stimulus-Driven and Goal-Directed Attention on Prepulse Inhibition of Brain Oscillations. Front Hum Neurosci. 2016 Jul 29;10:390.

Carriere N, Bourriez JL, Delval A, Derambure P, Defebvre L, Dujardin K. Impulse Control Disorders in Parkinson's Disease are Associated with Alterations in Reward-Related Cortical Oscillations. J Parkinsons Dis. 2016 Jun 28;6(3):651-66.

Baille G, De Jesus AM, Perez T, Devos D, Dujardin K, Charley CM, Defebvre L, Moreau C. Ventilatory Dysfunction in Parkinson's Disease. J Parkinsons Dis. 2016 Jun 16;6(3):463-71.

Moreau C, Devos D, Baille G, Delval A, Tard C, Perez T, Danel-Buhl N, Seguy D, Labreuche J, Duhamel A, Delliaux M, Dujardin K, Defebvre L. Are Upper-Body Axial Symptoms a Feature of Early Parkinson's Disease? PLoS One. 2016 Sep 21;11(9):e0162904.

Dujardin K, Auzou N, Lhommée E, Czernecki V, Dubois B, Fradet A, Maltete D, Meyer M, Pineau F, Schmitt E, Sellal F, Tison F, Vidal T, Azulay JP, Welter ML, Corvol JC, Durif F, Rascol O; NS-Park network. French consensus procedure for assessing cognitive function in Parkinson's disease. Rev Neurol (Paris). 2016 Nov;172(11):696-702.

Lefebvre S, Baille G, Jardri R, Plomhause L, Szaffarczyk S, Defebvre L, Thomas P, Delmaire C, Pins D, Dujardin K. Hallucinations and conscious access to visual inputs in Parkinson's disease. Sci Rep. 2016 Nov 14;6:36284. 10.1038/srep36284

Tard C, Dujardin K, Bourriez JL, Molaee-Ardekani B, Derambure P, Defebvre L, Delval A. Attention modulation during motor preparation in Parkinsonian freezers: A time-frequency EEG study. Clin Neurophysiol. 2016 Dec;127(12):3506-3515.


2015

Broen MP, Moonen AJ, Kuijf ML, Dujardin K, Marsh L, Richard IH, Starkstein SE, Martinez-Martin P, Leentjens AF. Factor analysis of the Hamilton Depression Rating Scale in Parkinson's disease. Parkinsonism Relat Disord. 2015 Feb;21(2):142-6.

Delval A, Moreau C, Bleuse S, Guehl D, Bestaven E, Guillaud E, Dujardin K, Defebvre L, Devos D. Gait and attentional performance in freezers under methylphenidate. Gait Posture. 2015 Feb;41(2):384-8.

Forjaz MJ, Ayala A, Martinez-Martin P, Dujardin K, Pontone GM, Starkstein SE, Weintraub D, Leentjens AF. Is the Parkinson anxiety scale comparable across raters? Mov Disord. 2015 Apr;30(4):545-51.

Rieu I, Martinez-Martin P, Pereira B, De Chazeron I, Verhagen Metman L, Jahanshahi M, Ardouin C, Chéreau I, Brefel-Courbon C, Ory-Magne F, Klinger H, Peyrol F, Schupbach M, Dujardin K, Tison F, Houeto JL, Krack P, Durif F. International validation of a behavioral scale in Parkinson's disease without dementia. Mov Disord. 2015 Apr 15;30(5):705-13.

Carriere N, Lopes R, Defebvre L, Delmaire C, Dujardin K. Impaired corticostriatal connectivity in impulse control disorders in Parkinson disease. Neurology. 2015 May 26;84(21):2116-23.

Moreau C, Meguig S, Corvol JC, Labreuche J, Vasseur F, Duhamel A, Delval A, Bardyn T, Devedjian JC, Rouaix N, Petyt G, Brefel-Courbon C, Ory-Magne F, Guehl D, Eusebio A, Fraix V, Saulnier PJ, Lagha-Boukbiza O, Durif F, Faighel M, Giordana C, Drapier S, Maltête D, Tranchant C, Houeto JL, Debû B, Azulay JP, Tison F, Destée A, Vidailhet M, Rascol O, Dujardin K, Defebvre L, Bordet R, Sablonnière B, Devos D; Parkgait-II Study Group. Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson's disease. Brain. 2015 May;138(Pt 5):1271-83.

Bocquillon P, Bourriez JL, Palmero-Soler E, Defebvre L, Derambure P, Dujardin K. Impaired Early Attentional Processes in Parkinson's Disease: A High-Resolution Event-Related Potentials Study. PLoS One. 2015 Jul 2;10(7):e0131654.

Tard C, Delval A, Duhamel A, Moreau C, Devos D, Defebvre L, Dujardin K. Specific Attentional Disorders and Freezing of Gait in Parkinson's Disease. J Parkinsons Dis. 2015 Jun 1;5(2):379-87.

Dujardin K, Moonen AJ, Behal H, Defebvre L, Duhamel A, Duits AA, Plomhause L, Tard C, Leentjens AF. Cognitive disorders in Parkinson's disease: Confirmation of a spectrum of severity. Parkinsonism Relat Disord. 2015 Nov;21(11):1299-305.

Auzou N, Dujardin K, Biundo R, Foubert-Samier A, Barth C, Duval F, Tison F, Defebvre L, Antonini A, Meissner WG. Diagnosing dementia in multiple system atrophy by applying Movement Disorder Society diagnostic criteria for Parkinson's disease dementia. Parkinsonism Relat Disord. 2015 Oct;21(10):1273-7.

Tard C, Delval A, Devos D, Lopes R, Lenfant P, Dujardin K, Hossein-Foucher C, Semah F, Duhamel A, Defebvre L, Le Jeune F, Moreau C. Brain metabolic abnormalities during gait with freezing in Parkinson's disease. Neuroscience. 2015 Oct 29;307:281-301.

Tard C, Demailly F, Delval A, Semah F, Defebvre L, Dujardin K, Moreau C. Hypometabolism in Posterior and Temporal Areas of the Brain is Associated with Cognitive Decline in Parkinson's Disease. J Parkinsons Dis. 2015 Sep 14;5(3):569-74.

2014

Plomhause L, Dujardin K, Boucart M, Herlin V, Defebvre L, Derambure P, Monaca Charley C. Impaired Visual Perception in Rapid Eye Movement Sleep Behavior Disorder. Neuropsychology. 2014:28(3):388-93.

Devos D, Moreau C, Maltête D, Lefaucheur R, Kreisler A, Eusebio A, Defer G, Ouk T, Azulay JP, Krystkowiak P, Witjas T, Delliaux M, Destée A, Duhamel A, Bordet R, Defebvre L, Dujardin K. Rivastigmine in apathetic but dementia and depression-free patients with Parkinson's disease: a double-blind, placebo-controlled, randomised clinical trial. J Neurol Neurosurg Psychiatry. 2014: 85(6):668-74.

Tard C, Dujardin K, Bourriez JL, Destée A, Derambure P, Defebvre L, Delval A. Attention modulates step initiation postural adjustments in Parkinson freezers. Parkinsonism Relat Disord. 2014: 20(3):284-9.

Bocquillon P, Bourriez JL, Palmero-Soler E, Molaee-Ardekani B, Derambure P, Dujardin K. The spatiotemporal dynamics of early attention processes: A high-resolution electroencephalographic study of N2 subcomponent sources. Neuroscience. 2014;271C:9-22.

Annic A, Bocquillon P, Bourriez JL, Derambure P, Dujardin K. Effects of stimulus-driven and goal-directed attention on prepulse inhibition of the cortical responses to an auditory pulse. Clin Neurophysiol. 2014 Aug;125(8):1576-88.

Carriere N, Besson P, Dujardin K, Duhamel A, Defebvre L, Delmaire C, Devos D. Apathy in Parkinson's disease is associated with nucleus accumbens atrophy: A magnetic resonance imaging shape analysis. Mov Disord. 2014 Jun;29(7):897-903.

Leentjens AF1, Dujardin K, Pontone GM, Starkstein SE, Weintraub D, Martinez-Martin P. The Parkinson Anxiety Scale (PAS): Development and validation of a new anxiety scale. Mov Disord. 2014 Jul;29(8):1035-43.

Annic A, Moreau C, Salleron J, Devos D, Delval A, Dujardin K, Touzet G, Blond S, Destée A, Defebvre L. Predictive Factors for Improvement of Gait by Low-Frequency Stimulation in Parkinson's Disease. J Parkinsons Dis. Jan1;4(3):413-20.

Devos D, Moreau C, Devedjian JC, Kluza J, Petrault M, Laloux C, Jonneaux A, Ryckewaert G, Garçon G, Rouaix N, Duhamel A, Jissendi P, Dujardin K, Auger F, Ravasi L, Hopes L, Grolez G, Firdaus W, Sablonnière B, Strubi-Vuillaume I, Zahr N, Destée A, Corvol JC, Pöltl D, Leist M, Rose C, Defebvre L, Marchetti P, Cabantchik ZI, Bordet R. Targeting chelatable Iron as a therapeutic modlaity in Parkinson's disease. Antioxid Redox Signal. 2014 Jul 10;21(2):195-210.

Delplanque J, Devos D, Huin V, Genet A, Sand O, Moreau C, Goizet C, Charles P, Anheim M, Monin ML, Buée L, Destée A, Grolez G, Delmaire C, Dujardin K, Dellacherie D, Brice A, Stevanin G, Strubi-Vuillaume I, Durr A, Sablonnière B. TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment. Brain. 2014 Oct;137(Pt 10):2657-63.

Dujardin K, Lopes R. Apathy and impaired recognition of emotion: are they related in Parkinson's disease? J Neurol Neurosurg Psychiatry. 2014, Oct;85(10):1061.

Starkstein SE, Dragovic M, Dujardin K, Marsh L, Martinez-Martin P, Pontone GM, Richard IH, Weintraub D, Leentjens AF. Anxiety Has Specific Syndromal Profiles in Parkinson Disease: A Data-Driven Approach. Am J Geriatr Psychiatry. 2014 Dec;22(12):1410-7.

Dujardin K, Langlois C, Plomhause L, Carette AS, Delliaux M, Duhamel A, Defebvre L. Apathy in untreated early-stage Parkinson disease: Relationship with other non-motor symptoms. Mov Disord. 2014 Dec;29(14):1796-801.

Dujardin K, Devos D. Genetic characterization of cognitive impairment in Parkinson's disease. Brain. 2014 Oct;137(Pt 10):2630-1.