Accepted Journal Papers/ Original Research Articles

Since joining IISER  

22. Kumar, M., Ojha, S., Rai, P., Joshi, A., Kamat, S. S., Mallik, R. M. (2019) Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver, Journal of Cell Biology (accepted, In Press). (Collaboration with Roop Mallik's lab)

21. Kulkarni, A., Soni, I., Kelkar, D. S., Dharmaraja, A. T., Sankar, R. K., Beniwal, G., Rajendran, A., Tamhankar, S., Chopra, S.*, Kamat, S. S.*, Chakrapani, H* (2019) Chemoproteomics of an indole-based quinone-epoxide identifies druggable vulnerabilities in vancomycin resistant Staphylococcus aureus, Journal of Medicinal Chemistry 62 (14), 6785-6795. (*co-corresponding authors). (Collaborative study with Harinath Chakrapani's lab and Sidharth Chopra's lab)[India Alliance Fellow Research highlight]

20. Malik, S. A., Acharya, J., Mehendale, N., Kamat, S. S., Ghaskadbi, S. (2019) Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation, Free Radical Research 53 (7), 815-827. (Collaboration with Saroj Ghaskadbi's lab)

19.  Chaplot, K., Pimpale, L., Ramalingham, B., Deivasigamani, S., Kamat, S. S., Ratnaparkhi, G. S. (2019) SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amyotrophic Lateral Sclerosis, Disease Models & Mechanisms 12, dmm033803, 1-15. (Collaboration with Girish Ratnaparki's lab)[Kriti's first person interview]

This paper featured on the Cover of the February 2019 issue !!! 

18.  Kelkar, D. S., Ravikumar, G., Mehendale, N., Singh, S., Joshi, A., Sharma, A. K., Mhetre, A., Rajendran, A., Chakrapani, H., Kamat, S. S. (2019) A chemical genetic screen identifies ABHD12 as an oxidized phosphatidylserine lipase, Nature Chemical Biology 15, 169-178. (Collaboration with Harinath Chakrapani's lab)[Vigyan Prasar, India Science Wire][Biotech Times][The Hindu BusinessLine][India Alliance Fellow Research highlight][IISER Pune Science Media Center video]

17.  Joshi, A., Shaikh, M., Singh, S., Rajendran, A., Mhetre, A., Kamat, S. S. (2018) Biochemical characterization of the PHARC associated serine hydrolase ABHD12 reveals its preference for very long chain lipids, Journal of Biological Chemistry 293 (44), 16953-16963. [India Alliance Fellow Research highlight]

This paper featured on the Cover of the 2nd November 2018 issue !!!

16.  Abhyankar, V., Kaduskar, B., Kamat, S. S., Deobagkar, D., Ratnaparkhi, G. S. (2018) Drosophila DNA/RNA methyltransferase contributes to robust host defense in ageing animals by regulating sphingolipid metabolism, Journal of Experimental Biology 221 (22), 1-10. (Collaboration with Girish Ratnaparkhi's lab

15.  Pathak, D., Mehendale, N., Singh, S., Mallik, R., Kamat, S. S. (2018) Lipidomics suggests a new role for ceramide synthase in phagocytosis, ACS Chemical Biology 13, 2280-2287. (Collaboration with Roop Mallik's lab)[India Alliance Fellow Research highlight][Neelay & Divya: Introducing our authors]

This paper featured on the Cover of the August 2018 issue !!!

14.  Rai, P., Kumar, M., Sharma, G., Barak, P., Das, S., Kamat, S. S., Mallik, R. (2017) Kinesin-dependent mechanism for controlling triglyceride secretion from the liver, PNAS 114, 12958-12963. (Collaboration with Roop Mallik's lab) [BioTech Times][Indian Express]

From Ph.D & Postdoctoral work

13.  Kory, N., Grond, S., Kamat, S. S., Li, Z., Krahmer, N., Chitraju, C., Zhou, P., Fronlich, F., Semova, I., Ejsing, C., Zechner, R., Cravatt, B. F., Farese, R. V., Walther, T. C. (2017) Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism, Journal of Lipid Research 58, 226-235. 

12.  Kolar, M. J., Kamat, S. S., Parsons, W. H., Homan, E., Maher, T.,  Peroni, O., Syed, I., Molven, A., Kahn, B. B., Cravatt, B. F., Saghatelian, A. (2016) Branched fatty acid esters of hydroxy fatty acids are the preferred substrates of the MODY8 gene carboxyl ester lipase, Biochemistry 55, 4636-4641.

11.  Ogura, Y., Parsons, W. H., Kamat, S. S., Cravatt, B. F. (2016) A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines, Nature Chemical Biology 12, 669-671.

10.  Parsons, W. H., Kolar, M. J., Kamat, S. S., Cognetta, A. B. III, Hulce, J. J., Saez, E., Kahn, B., Saghatelian, A., Cravatt, B. F. (2016) AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs, Nature Chemical Biology 12, 367-372. [Scripps News Release] [Eureka Alert]

9.  Kamat, S. S., Camara, K., Parsons, W. H., Chen, D. H., Dix, M. M., Bird, T. D., Howell, A. R., Cravatt, B. F. (2015) Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay, Nature Chemical Biology 11, 164-171. [Scripps News Release] [Nat Chem Biol News & Views] [Drug Discovery News] [Eureka Alert]

8.  Camara, K., Kamat, S. S., Lasota, C. C., Cravatt, B. F., Howell, A. R. (2015) Combining cross-metathesis and activity based protein profiling: new β-lactone motifs for targeting serine hydrolases, Bio. Org. Med. Chem. Lett. 25, 317-321.

7.  Korczynska, M., Xiang, D. F., Zhang, Z., Xu, C., Narindoshvili, T., Kamat, S. S., Williams, H. J., Chang, S. S., Kolb, P., Hillerich, B. S., Sauder, J. M., Burley, S. K., Almo, S. C., Swaminathan, S., Shoichet, B. K., Raushel, F. M. (2014) Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate, Biochemistry 53, 4727-4738. 

6.  Kamat, S. S., Burgos, E. S., Raushel, F. M. (2013) Potent inhibition of the C-P lyase nucleosidase PhnI by immucillinA-triphosphate, Biochemistry 52, 7366-7368.

5.  Kamat, S. S., Williams, H. J., Dangott L. J., Chakrabarti, M., Raushel, F. M. (2013) The catalytic mechanism for the aerobic formation of methane by bacteria, Nature 497, 132-36. [F1000 Recommendations] [Angewandte Chemie Commentary] [Science Commentary]

4.  Kamat, S. S., Williams, H. J., Raushel, F. M. (2011) Intermediates in the transformation of phosphonates to phosphate by bacteria, Nature 480, 570-73. [F1000 Recommendations] [Chembiochem Commentary]

3.  Kamat, S. S., Holmes-Hampton, G. P., Bagaria, A., Kumran, D., Tichy, S. E., Gheyi, T., Zheng, X., Bain, K., Groshong, C., Emtage, S., Sauder, J. M., Burley, S. K., Swaminathan, S., Lindahl, P. A., Raushel, F. M. (2011) The catalase activity of diiron adenine deaminase, Protein Science 20, 2080-94.

2.  Kamat, S. S., Fan, H., Sauder, J. M., Burley, S. K., Shoichet, B. K., Sali, A., Raushel, F. M. (2011): Enzymatic deamination of the epigenetic base N-6-methyladenine, JACS 133, 2080-83. [Nature Structural Biology Commentary]

1.  Kamat, S. S., Bagaria, A., Kumaran, D., Holmes-Hampton, G. P., Fan, H., Sali, A., Sauder, J. M., Burley, S. K., Lindahl, P. A., Swaminathan, S., Raushel, F. M. (2011): Catalytic mechanism and three dimensional structure of adenine deaminase, Biochemistry 50, 1917-27. (Highlighted on Biochemistry webpage) 

Invited Scientific Reviews/ Book Chapters/ Proceedings

Since joining IISER

7.  Kamat, S. S., Singh, S. S., Rajendran, A., Game, S., Zechel , D. L. (2018) Enzymatic strategies for the catabolism of organophosphonates, Comprehensive Natural Products III, Enzymes and Enzyme Mechanisms (Polar Intermediates) Edited by Chris Whitman, Paul Fitzpatrick, Kenji Watanabe. (Collaborative book chapter with David Zechel) (Accepted, In Press). 

6.  Ulrich, E., Kamat, S.S.*, Hove-Jensen, B.*, Zechel, D. L.* (2018) Chapter 13: Methylphosphonic acid biosynthesis and catabolism in pelagic bacteria, Methods in Enzymology Vol. 605, 351-426 (*co-corresponding authors). (Collaborative review with David Zechel and Bjarne Hove-Jensen)

From Ph.D & Postdoctoral work

5. Kamat, S. S., Raushel, F. M. (2015) PhnJ - A novel radical SAM enzyme from the C-P lyase complex, Perspectives in Science 4, 32-37. 

4.  Kamat, S. S., Raushel, F. M. (2013) Adenine Deaminase, Encyclopedia of Inorganic and Bioinorganic Chemistry (former Handbook of Metalloproteins) 1-9.

3.  Kamat, S. S., Raushel F. M. (2013) The enzymatic conversion of phosphonates to phosphate by bacteria, Current Opinions in Chemical Biology 17, 589-596

2.  Kamat, S. S.Williams, H. J., Raushel, F. M. (2013) Phosphonates to phosphate: A functional annotation of the essential genes of the phn operon in Escherichia coli, 5th International Symposium on Experimental Standard Conditions of Enzyme Characterizations (ESCEC)1-18.

1. Kamat, S. S. (2012) Functional annotation and mechanistic characterization of enzymes with unknown functions: Studies on adenine deaminase, N-6-methyladenine deaminase and the C-P lyase pathway. Ph. D Thesis, Texas A&M University.

Pre-prints (all from IISER). 

1.  Abhyankar, V., Kaduskar, B., Kamat, S. S., Deobagkar, D., Ratnaparkhi, G. S. (2018) Dropsphila DNA/RNA methyltransferase contributes to robust host defense in ageing animals by regulating sphingolipid metabolism. bioRxiv

2.  Chaplot, K., Pimpale, P., Ramalingam, B., Deivaigamani, S., Kamat, S. S., Ratnaparkhi, G. (2018) SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amyotrophic Lateral Sclerosis. bioRxiv


1. Cravatt, B. F., Kamat, S. S., Parsons, W. H., Howell, A. R., Camara, K., Anderson, A. (2017) Lactone compounds and methods of making and using same. US Patent: 20170313669. 

Miscellaneous Invited Articles

1.  Kamat, S. S. (2019) Understanding the role of molecular motors in living cells: an odyssey from physics to biology, Current Science 116, 14-16. [This is a news article commemorating Roop's Infosys Award]

Link to Siddhesh's Google Scholar Profile and Pubmed Bibliography Page