Accepted Journal Papers/ Original Research Articles

Since joining IISER  

19. Chaplot, K., Pimpale, L., Ramalingham, B., Deivasigamani, S., Kamat, S. S., Ratnaparkhi, G. S. (2018) SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amyotrophic Lateral Sclerosis, Disease Models & Mechanisms (revision submitted). (Collaboration with Girish Ratnaparki's lab)


18. Kelkar, D. S., Ravikumar, G., Mehendale, N., Singh, S., Joshi, A., Sharma, A. K., Mhetre, A., Rajendran, A., Chakrapani, H., Kamat, S. S. (2018) A chemical genetic screen identifies ABHD12 as an oxidized phosphatidylserine lipase, Nature Chemical Biology (Accepted, In Press). (Collaboration with Harinath Chakrapani's lab)


17. Joshi, A., Shaikh, M., Singh, S., Rajendran, A., Mhetre, A., Kamat, S. S. (2018) Biochemical characterization of the PHARC associated serine hydrolase ABHD12 reveals its preference for very long chain lipids, Journal of Biological Chemistry 293 (44), 16953-16963. [India Alliance Fellow Research highlight]













16. Abhyankar, V., Kaduskar, B., Kamat, S. S., Deobagkar, D., Ratnaparkhi, G. S. (2018) Drosophila DNA/RNA methyltransferase contributes to robust host defense in ageing animals by regulating sphingolipid metabolism, Journal of Experimental Biology 221 (22), 1-10. (Collaboration with Girish Ratnaparkhi's lab


15. Pathak, D., Mehendale, N., Singh, S., Mallik, R., Kamat, S. S. (2018) Lipidomics suggests a new role for ceramide synthase in phagocytosis, ACS Chemical Biology 13, 2280-2287. (Collaboration with Roop Mallik's lab)[India Alliance Fellow Research highlight][Neelay & Divya: Introducing our authors]

This paper featured on the Cover of the August 2018 issue !!!










14. Rai, P., Kumar, M., Sharma, G., Barak, P., Das, S., Kamat, S. S., Mallik, R. (2017) Kinesin-dependent mechanism for controlling triglyceride secretion from the liver, PNAS 114, 12958-12963. (Collaboration with Roop Mallik's lab) [BioTech Times][Indian Express]




From Ph.D & Postdoctoral work

13. Kory, N., Grond, S., Kamat, S. S., Li, Z., Krahmer, N., Chitraju, C., Zhou, P., Fronlich, F., Semova, I., Ejsing, C., Zechner, R., Cravatt, B. F., Farese, R. V., Walther, T. C. (2017) Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism, Journal of Lipid Research 58, 226-235. 

12. Kolar, M. J., Kamat, S. S., Parsons, W. H., Homan, E., Maher, T.,  Peroni, O., Syed, I., Molven, A., Kahn, B. B., Cravatt, B. F., Saghatelian, A. (2016) Branched fatty acid esters of hydroxy fatty acids are the preferred substrates of the MODY8 gene carboxyl ester lipase, Biochemistry 55, 4636-4641.

11. Ogura, Y., Parsons, W. H., Kamat, S. S., Cravatt, B. F. (2016) A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines, Nature Chemical Biology 12, 669-671.

10. Parsons, W. H., Kolar, M. J., Kamat, S. S., Cognetta, A. B. III, Hulce, J. J., Saez, E., Kahn, B., Saghatelian, A., Cravatt, B. F. (2016) AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs, Nature Chemical Biology 12, 367-372. [Scripps News Release] [Eureka Alert]

9.  Kamat, S. S., Camara, K., Parsons, W. H., Chen, D. H., Dix, M. M., Bird, T. D., Howell, A. R., Cravatt, B. F. (2015) Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay, Nature Chemical Biology 11, 164-171. [Scripps News Release] [Nat Chem Biol News & Views] [Drug Discovery News] [Eureka Alert]

8.  Camara, K., Kamat, S. S., Lasota, C. C., Cravatt, B. F., Howell, A. R. (2015) Combining cross-metathesis and activity based protein profiling: new β-lactone motifs for targeting serine hydrolases, Bio. Org. Med. Chem. Lett. 25, 317-321.

7.  Korczynska, M., Xiang, D. F., Zhang, Z., Xu, C., Narindoshvili, T., Kamat, S. S., Williams, H. J., Chang, S. S., Kolb, P., Hillerich, B. S., Sauder, J. M., Burley, S. K., Almo, S. C., Swaminathan, S., Shoichet, B. K., Raushel, F. M. (2014) Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate, Biochemistry 53, 4727-4738. 

6.  Kamat, S. S., Burgos, E. S., Raushel, F. M. (2013) Potent inhibition of the C-P lyase nucleosidase PhnI by immucillinA-triphosphate, Biochemistry 52, 7366-7368.

5.  Kamat, S. S., Williams, H. J., Dangott L. J., Chakrabarti, M., Raushel, F. M. (2013) The catalytic mechanism for the aerobic formation of methane by bacteria, Nature 497, 132-36. [F1000 Recommendations] [Angewandte Chemie Commentary] [Science Commentary]

4.  Kamat, S. S., Williams, H. J., Raushel, F. M. (2011) Intermediates in the transformation of phosphonates to phosphate by bacteria, Nature 480, 570-73. [F1000 Recommendations] [Chembiochem Commentary]

3.  Kamat, S. S., Holmes-Hampton, G. P., Bagaria, A., Kumran, D., Tichy, S. E., Gheyi, T., Zheng, X., Bain, K., Groshong, C., Emtage, S., Sauder, J. M., Burley, S. K., Swaminathan, S., Lindahl, P. A., Raushel, F. M. (2011) The catalase activity of diiron adenine deaminase, Protein Science 20, 2080-94.

2.  Kamat, S. S., Fan, H., Sauder, J. M., Burley, S. K., Shoichet, B. K., Sali, A., Raushel, F. M. (2011): Enzymatic deamination of the epigenetic base N-6-methyladenine, JACS 133, 2080-83. [Nature Structural Biology Commentary]

1.  Kamat, S. S., Bagaria, A., Kumaran, D., Holmes-Hampton, G. P., Fan, H., Sali, A., Sauder, J. M., Burley, S. K., Lindahl, P. A., Swaminathan, S., Raushel, F. M. (2011): Catalytic mechanism and three dimensional structure of adenine deaminase, Biochemistry 50, 1917-27. (Highlighted on Biochemistry webpage) 
                                

Invited Reviews/ Book Chapters/ Proceedings

Since joining IISER

7.  Kamat, S. S., Singh, S. S., Rajendran, A., Game, S., Zechel , D. L. (2018) Enzymatic strategies for the catabolism of organophosphonates, Comprehensive Natural Products III, Enzymes and Enzyme Mechanisms (Polar Intermediates) Edited by Chris Whitman, Paul Fitzpatrick, Kenji Watanabe. (Collaborative book chapter with David Zechel) (under review). 


6.  Ulrich, E., Kamat, S.S.*, Hove-Jensen, B.*, Zechel, D. L.* (2018) Chapter 13: Methylphosphonic acid biosynthesis and catabolism in pelagic bacteria, Methods in Enzymology Vol. 605, 351-426 (*co-corresponding authors). (Collaborative review with David Zechel and Bjarne Hove-Jensen)




From Ph.D & Postdoctoral work

5. Kamat, S. S., Raushel, F. M. (2015) PhnJ - A novel radical SAM enzyme from the C-P lyase complex, Perspectives in Science 4, 32-37. 

4.  Kamat, S. S., Raushel, F. M. (2013) Adenine Deaminase, Encyclopedia of Inorganic and Bioinorganic Chemistry (former Handbook of Metalloproteins) 1-9.

3.  Kamat, S. S., Raushel F. M. (2013) The enzymatic conversion of phosphonates to phosphate by bacteria, Current Opinions in Chemical Biology 17, 589-596

2.  Kamat, S. S.Williams, H. J., Raushel, F. M. (2013) Phosphonates to phosphate: A functional annotation of the essential genes of the phn operon in Escherichia coli, 5th International Symposium on Experimental Standard Conditions of Enzyme Characterizations (ESCEC)1-18.

1. Kamat, S. S. (2012) Functional annotation and mechanistic characterization of enzymes with unknown functions: Studies on adenine deaminase, N-6-methyladenine deaminase and the C-P lyase pathway. Ph. D Thesis, Texas A&M University.

Pre-prints:

Since joining IISER

1. Abhyankar, V., Kaduskar, B., Kamat, S. S., Deobagkar, D., Ratnaparkhi, G. S. (2018) Dropsphila DNA/RNA methyltransferase contributes to robust host defense in ageing animals by regulating sphingolipid metabolism. bioRxiv

2. Chaplot, K., Pimpale, P., Ramalingam, B., Deivaigamani, S., Kamat, S. S., Ratnaparkhi, G. (2018) SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amyotrophic Lateral Sclerosis. bioRxiv

Patents

1. Cravatt, B. F., Kamat, S. S., Parsons, W. H., Howell, A. R., Camara, K., Anderson, A. (2017) Lactone compounds and methods of making and using same. US Patent: 20170313669. 


Link to Siddhesh's Google Scholar Profile and Pubmed Bibliography Page