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  • Course schedule
    February 22
    Protein Folding - The Life and Death of Proteins
            Exiting the Ribosome
            Co-translational folding and degradation
            Chaperones and Chaperonins
            Folding in compartments (Cytosol and ER)
            Proteasomal Degradation 

    March 2
    Protein Folding Quality Control - To Fold or to Destroy
            Chaperone systems and Quality Control
            Ubiquitination of misfolded proteins
            Quality Control in Compartments (Cytosol, Nucleus, ER)

    March 8
    Aggregation and Inclusions - Sticking Together
            All proteins can aggregate
            Neurodegenerative Diseases
            Are inclusions toxic or protective?

    March 15
    Proteostasis - When Things Go Wrong (guest discussion)
            Protein folding stress
            Global folding and marginal stability
            Folding buffers
            Oxidative stress

    March 22
    Aging - Aging Old Question (guest discussion)
            Basic aging models
            Aging onset diseases
            Aging and proteostasis
            Aging and neurodegeneration

    March 29
    Spatial Quality Control - If You Can't Beat Them, Get Rid of Them
            Asymmetric inheritance
            Aging in yeast
            The awesome power of yeast ... prions

    April 5
    Spatial Organization of the Cytosol and its Functions - More Than Just a Bag of Enzymes
            Molecular crowding
            Enzymatic channeling

    May 3
    How to Give Scientific Presentations - Talking about Talking

    May 17
    Live Cell Imaging - A Movie is Worth a Thousand Pictures
            What can imaging do for you?
            Why live cell imaging
            F-ing and molecular dynamics (FRAP, FLIP, FLIM, FRET)
            Different approaches in microscopy (Confocality, EM, Spinning Disk, Deconvolution)
            Breaking the diffraction limit

    May 24
    Synthetic Gene Array - The (even more) Awesome Power of Yeast Genetics (guest lecture Michal Breker)
            The dynamic localization of the yeast genome
            The dynamic expression of the yeast genome
    Student Presentations - Two to three weeks at the end of the semester
    Posted May 3, 2011, 4:40 AM by Daniel Kaganovich
  • Course format
    The course will consist of 8-10 sessions which will be divided into a short background presentation (usually by me), followed by a discussion of one or two papers which will be assigned in advance. 

    For 8 of the sessions, one of the students will be primarily responsible for the assigned research paper (mainly for presenting the topic, summarizing the background, and showing all of the figures in a powerpoint). However, we will all discuss the paper and the figures together. 

    Participation will entail understanding the background, figures, and asking interesting questions.

    During the first few weeks of the semester students are encouraged to select a final project topic in groups of two. The topics can be selected from the class titles listed above, but might also be something we do not discuss in class according to student preferences. The purpose of the final project will be to present an interesting question in the chosen field or topic. We will discuss appropriate background literature and interesting directions together on a one on one basis. More details about the final project will be discussed in class. 

    Posted Feb 19, 2011, 7:37 AM by Daniel Kaganovich
  • Course location
    We will usually be meeting on Tuesday 6-8pm in my office (5th floor, 3rd wing, 3-536). Note change in location from last time!!
    Posted Feb 28, 2011, 10:33 AM by Daniel Kaganovich
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Course schedule