Jun Hee Lee, Ph.D.
Department of Molecular and Integrative Physiology
University of Michigan Medical School
109 Zina Pitcher Place, 3019 BSRB
Ann Arbor, MI 48109-2200
1. Personal Information
Name : Lee, Jun Hee
Citizenship : Republic of Korea (South Korea)
2. Education and Training
Ph.D. (2006) Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea
Major: Biological Sciences
Dissertation title: Functional Analysis of p53 and LKB1 in Drosophila
M.S. (2002) KAIST, Daejeon, Korea
Major: Biological Sciences
Dissertation title: PDZ-GEF, a Novel Component of the MAPK Pathway
B.S. (2000) KAIST, Daejeon, Korea
Major: Biological Sciences
Postdoctoral Fellow (2007 - 2011): UC San Diego, La Jolla, USA
Subject: Physiological function of Sestrin proteins
Visiting Researcher (2009 - 2011): Sanford-Burnham Institute, La Jolla, USA
Subject: The role of Sestrin during cardiac aging
Postdoctoral Researcher (2006 - 2007): KAIST, Daejeon, Korea
Subject: The role of LKB1 and AMPK in regulating cell polarity
Assistant Professor (2011 - present): Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, USA
Research Assistant Professor (2011 - present): Institute of Gerontology, University of Michigan Medical School, Ann Arbor, USA
Member (2011 - present): University of Michigan Comprehensive Core Cancer Center, Ann Arbor, USA
Member (2012 - present): Center for Organogenesis, Ann Arbor, USA
Associate Member (2012 - present): Michigan Gastrointestinal Peptide Research Center, Ann Arbor, USA
4. Honors and Awards
1. Excellence Scholarship for 1st class new students (1997), awarded by KAIST
2. Academic Excellence Scholarship (1997-1999), awarded by KAIST
3. Suma Cum Laude (2000), awarded by KAIST
4. National Scholarship (2000-2005), awarded by MOST
5. Valedictorian (2006), nominated by KAIST
6. The best Korean Bio-scientist (2010, 2007 and 2002), nominated by Biological Research Information Center
7. 10 Outstanding Scientists (2007), nominated by Ministry of Science and Technology (MOST) and Korean Science and Engineering Foundation
8. Next Generation Postdoctoral Fellowship (2007-2008), awarded by Korea Research Foundation
9. Postdoctoral Travel Award (2010), awarded by Society for Developmental Biology
10. Human Frontier Science Program Long-term Fellowship (2008-2011), awarded by International Human Frontier Science Program Organization
11. Biological Science Scholar (2011), awarded by University of Michigan Medical School
12. Research Career Development Core Award (2012), awarded by the Claude Pepper Older Americans Independence Center at the University of Michigan
13. Liver Scholar (2012), awarded by American Association for the Study of Liver Diseases (AASLD) and the American Liver Foundation (ALF)
14. Ellison New Scholar in Aging (2012), awarded by the Ellison Medical Foundation (EMF).
15. Basic Science Award (2013), awarded by American Diabetes Association (ADA).
A. Peer-reviewed original research articles
1. Cho, K. S., Lee, J. H., Kim, S., Kim, D., Koh, H., Lee, J., Kim, C., Kim, J. and Chung, J. (2001). Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. Proc. Natl. Acad. Sci. U S A 98, 6144-6149.
2. Lee, J. H., Cho, K. S., Lee, J., Yoo, J. and Chung, J. (2001). Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila. Gene 271, 233-238.
3. Lee, J. H., Cho, K. S., Lee, J., Kim, D., Lee, S. B., Yoo, J., Cha, G. H. and Chung, J. (2002). Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway. Mol. Cell Biol. 22, 7658-7666.
4. Cha, G. H., Cho, K. S., Lee, J. H., Kim, M., Kim, E., Park, J., Lee, S. B. and Chung, J. (2003). Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol. Cell Biol. 23, 7982-7991.
5. Kim, M., Cha, G. H., Kim, S., Lee, J. H., Park, J., Koh, H., Choi, K. Y. and Chung, J. (2004). MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development. Mol. Cell Biol. 24, 573-583.
6. Lee, J. H., Lee, E., Park, J., Kim, E., Kim, J. and Chung, J. (2003). In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett. 550, 5-10.
7. Kim, M, Lee, J. H., Koh, H., Lee, S. Y., Jang, C., Chung, C. J., Sung, J. H., Blenis, J. and Chung, J. (2006) Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. EMBO J. 25, 3056-3067.
8. Kim M., Lee, J. H., Lee, S. Y., Kim, E. and Chung, J. (2006) Caspar, a suppressor of antibacterial immunity in Drosophila. Proc. Natl. Acad. Sci. U S A 103, 16358-16364.
9. Lee, J. H., Koh, H., Kim, M., Park, J., Lee, S. Y., Lee, S. and Chung, J. (2006) JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila. Cell Death Differ. 13, 1110-1122.
10. Lee, J. H., Koh, H., Kim, M., Kim, Y., Lee, S. Y., Karess, R., Lee, S., Shong, M., Kim, J., Kim, J. and Chung, J. (2007) Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature, 447, 1017-1020.
11. Sun, D., Lee, G., Lee, J. H.*, Kim, H., Rhee, H., Park, S., Kim, K., Kim, Y., Kim, B. Y., Hong, J., Park, C., Choy, H. E., Kim, J. H., Jeon, Y. H., Chung, J. (2010) A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat. Struct. Mol. Biol. 17, 1188-1194. *Co-first author.
12. Kong, S. D., Zhang, W., Lee, J. H., Brammer, K., Lal, R., Karin, M., Jin, S. (2010) Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release. Nano Lett. 10, 5088-5092.
13. Park, E. J., Lee, J. H., Yu, G., He, G., Ali, S. R., Holzer, R. G., Osterreicher, C. H., Takahashi, H., Karin, M. (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell, 140, 197-208.
14. Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science, 327, 1213-1218.
15. Lee, J. H.**, Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin 2 and 3. Cell Metab., 16, 311-321. **Co-corresponding author.
B. Review articles
1. Lee, J. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrins at the crossroad between stress and aging. Aging, 2, 369-374.
2. Budanov, A. V., Lee, J. H., Karin, M. (2010) Stressin’ Sestrins take an aging fight. EMBO Mol. Med., 2, 388-400.
C. Book chapters
1. Lee, J. H., Bier, E. (2011) The Protective role of Sestrins against chronic TOR activation and oxidative stress. Oxidative Stress in Vertebrates and Invertebrates, Wiley-Blackwell, pp. 337-346.
2. Lee, J. H. (2012) Sestrins. McGraw-Hill 2012 Yearbook of Science & Technology, McGraw-Hill, New York, pp. 234-237.
6. Invited talks
1. Lee, J. H. (2009) Sestrin, a feedback modulator of TOR-dependent physiology. Burnham Institute of Medical Research, Development and Aging group meeting
2. Lee, J. H. (2010) Sestrin keeps mTOR under control. UCSD, Pharmacology Research Discussions.
3. Lee, J. H. (2010) Sestrin Protects Organism against Age- and Obesity-associated Pathologies. Korean-American Scientists and Engineers Association (KSEA) Seminar Series.
4. Lee, J. H. (2010) Sestrin as a guardian against age- and obesity-associated pathologies. The UM Geriatrics Center.
5. Lee, J. H. (2010) Sestrin as a guardian against age- and obesity-associated pathologies. Beth Israel Deaconess Medical Center at Harvard Medical School.
6. Lee, J. H. (2010) Genetic Control of Aging by a Sestrin-TOR Network, The UM Department of Physiology.
7. Lee, J. H. (2012) Interdisciplinary Collaborations: Role of Sestrins against age- and obesity-associated pathologies. Undergraduate Research Opportunity Program Research Seminar Series.
8. Lee, J. H. (2012) Sestrin, a feedback suppressor of chronic TOR-associated pathologies. 2012 Shock Center Research Conference.
9. Lee, J. H. (2012) Maintenance of metabolic homeostasis by Sestrin-family proteins. UM-WSU Physiology Symposium (scheduled).
7. Membership in Professional Societies
1. American Physiological Society
2. American Association for the Study of Liver Diseases
8. Teaching Experiences
A. Participation in teaching and lecturing
1. BS315 (KAIST) Genetics Experiment, Teaching Assistant, 2002
2. BS102 (KAIST) Experimental Design in Biology, Teaching Assistant, 2002
3. BS315 (KAIST) Genetics Experiment, Drosophila Genetics, Invited Lecture, 2003, 2007
4. NQe362 (KAIST) Radiobiology: Introduction to Molecular Biology, Invited Lecture, 2006
B. Participation in mentoring
1. BS495 (KAIST) BS Research, Supervisor, 2000-2006 (total 8 students)
2. BISP199 (UCSD) BS/MS Research, Supervisor, 2008-2010 (one student)
3. UROP (UM) Undergrauate Research Opportunity Program, Supervisor, 2011-2012 (one student)
4. MCDB300/400 (UM), Undergraduate/Advanced Research, Supervisor, 2012 (one student)
C. Community services
1. See-KAIST (science exhibition for non-scientific public), Instructor, 2001
2. Open-KAIST (instructive program for non-scientific public), Instructor, 2002-2004
3. International Education Week (UCSD), Poster Presenter, 2010
D. Other leadership roles
1. Freshman Orientation in KAIST, Class Instructor, 1998-1999
2. Inter-Varsity Christian Fellowship, Group Leader, 1998-2000
3. Army training course for special research agents, Korea Army Training Center, Trainee Platoon Leader, 2006
9. Research Support
A. Current Research Support
Liver Scholar Award (PI: Lee, Jun Hee) 07/01/2012-06/30/2015
American Liver Foundation/American Association for the Study of Liver Diseases
Title: Protective role of Sestrin2 against obesity-associated pathologies in liver
The major goal of this support is to support salary of the PI while conducting the research on the function of Sestrin2 in liver metabolism in mice.
New Scholar Award in Aging (PI: Lee, Jun Hee) 08/01/2012-07/31/2016
Ellison Medical Foundation (AG-NS-0932-12)
Title: Sestrins at the crossroads between nutrition, aging and metabolism.
The major goal of this support is to generate and exploit mouse models for assessing the role of Sestrins in metabolic homeostasis in the context of aging and obesity.
ADA Basic Science Award (PI: Lee, Jun Hee) 01/01/2013-12/31/2015
American Diabetes Association (1-13-BS-106)
Title: Maintenance of insulin signaling sensitivity by sestrin2-mediated feedback loop
The major goal of this support is to study the mechanistic details of how mouse Sestrin2 contributes to the maintenance of insulin signaling sensitivity during obesity.
Geriatrics Center Pilot Grant (PI: Lee, Jun Hee) 09/01/2012-08/31/2013
Claude Pepper Older Americans Center/NIH (P30 AG024824)
Title: The role of Sestrin 2 and 3 against age- and obesity-associated metabolic derangements
The goal of this support is to investigate if concomitant mutation of Sesn2 and Sesn3 can cause severe metabolic derangements in liver during normal aging and upon obesity
Aging Rodent Core Support (PI: Lee, Jun Hee) 02/16/2012-06/30/2014
Nathan Shock Center of Excellence in Aging/NIH (P30 AG013283)
The major goals of this support are (i) to investigate whether Sesn2/3 are protecting aged animals from developing metabolic abnormalities, and (ii) to generate Sesn1-knockout mice for future investigation about Sesn1’s myoprotective function during muscle aging.
MCubed Research Initiative (PI: Lee, Jun Hee) 01/01/2013-06/30/2014
University of Michigan
Title: Understanding Beneficial Effects of Sestrins, Exercise and Mitophagy
The goal of this support is to conduct pilot experiments in Drosophila to see whether Sestrin overexpression can be used as exercise mimetics and can produce beneficial effects in extending health span.
RCDC Award (PI: Lee, Jun Hee) 09/01/2012-08/31/2013
Claude Pepper Older Americans Center/NIH (P30 AG024824)
The goal of this support is to support salary of the PI while conducting the research on the function of Sestrin-family proteins during aging and age-associated pathologies.B. Completed Research Support
LT00653/2008-L (PI: Lee, Jun Hee) 08/01/2008-07/31/2011
The International Human Frontier Science Program Organization
Title: IKKa as a component of TGFb signaling in prostate cancer (CaP).
The major goal of this project is to investigate genetic and functional relationships between IKKa and TGFb signaling in Drosophila and mouse prostate cancer model.
KRF-2007-C00096 (PI: Lee, Jun Hee) 08/01/2007-07/31/2008
Korea Research Foundation
Title: Molecular mechanism of chronic inflammation-promoted tumorigenesis.
The major goals of this project are to investigate the mechanistic relationship between inflammation and tumorigenesis using mouse cancer models.