Welcome to the Personal Home Page of Dr Jiapu Zhang! https://www.youtube.com/user/jiapuzhang/videos    http://blog.sciencenet.cn/home.php?mod=space&uid=498408 



New Book: Zhang JP (2019) Molecular Dynamics Studies of α-synuclein Protein Structures: Mechanism Underlying the Parkinson's Disease and Movement Disorders,





Book "Zhang JP (2018) Molecular Dynamics Analyses of Prion Protein Structures (1st ed. 2018 Edition): The Resistance to Prion Diseases Down Under, Springer, ISBN 978-981-10-8814-8 (Print, Hardcover),  978-981-10-8815-5 (Online, eBook), DOI 10.1007/978-981-10-8815-5, Series ISSN 1571-4853 Volume 10, Copyright Holder Springer Nature Singapore Pte Ltd (Library of Congress Control Number: 2018943680)"
The Front Matter (Preface, Acknowledgments, Contents, About the Author, Acronyms), Front Matter of Part I (Prion Resistance Species), Front Matter of Part II (beta2-alpha2 Loop), Front Matter of Part III (Human Mutants), Front Matter of Part IV (PrP Binding/Docking), Front Matter of Part V (Prion Peptides with Cross-beta Structures), Back Matter (References & Index), and each Chapter's Abstract-Key Words-References of the above book are free at website https://link.springer.com/book/10.1007/978-981-10-8815-5 Many pages are free at https://books.google.com.au/books?isbn=9811088152

Book "Zhang JP (2015) Molecular Structures and Structural Dynamics of Prion Proteins and Prions: Mechanism Underlying the Resistance to Prion Diseases, Springer, ISBN 978-94-017-7317-1 (Print, Hardcover) 978-94-024-0445-6 (Print, Softcover) 978-94-017-7318-8 (Online, eBook), DOI 10.1007/978-94-017-7318-8, Series ISSN 1571-4853 Volume 9, Copyright Holder Springer Science+Business Media Dordrecht (Library of Congress Control Number: 2015949386)" 
The Front Matter (Preface, Contents, About the Author, Acronyms), Front Matter of Part I (Molecular Dynamics of Prion Proteins), Front Matter of Part II (Molecular Modeling of Prions), Back Matter, and each Chapter's Abstract-Key Words-References of the above book are free at website http://link.springer.com/book/10.1007/978-94-017-7318-8; Many pages are free at https://books.google.com.au/books?isbn=9401773181, a book Review from the Association of Computing Machinery -
"There is a wealth of information and insight in the results presented and in the methods employed. The research is important. The methods used are innovative. Studying this book is worth the effort."
, and introduced by Physics Today etc., with downloads ("your book was one of the top 25% most downloaded eBooks in the relevant SpringerLink eBook Collection in 2016" & "your book was one of the top 50% most downloaded eBooks in the relevant SpringerLink eBook Collection in 2017" - Springer),

A Podcast for the Social Media Marketing of the Bentham Science Publishers (https://youtu.be/ikL0gh7jYJM):

YouTube Video

I would like to discuss our recent study that was published in the journal of Current Pharmaceutical Biotechnology. This study's title is “a survey and a molecular dynamics MD study on the central hydrophobic region of prion protein”.
•The central hydrophobic region of PrP includes a palindrome and a 3 repeated GxxxG motif.
•Firstly, we did a detailed survey on this region for the last 28 years and especially for the last 5 years.
•Secondly, in the PDB Bank, we already have the NMR structure of this region, the PDB ID is 2LBG.We did MD study for the wild-type and its 17 mutants.
• From the MD secondary structures and snapshots, we know all these 18 models start to unfold from the second nanosecond.
•We can observe the following 5 points: (1) The NMR structure short α-helix can be broken into 2 parts, usually just from the mutation point. The first half is very unstable, but the second half is much more stable than the first half, due to 3 hydrogen bonds always there.(2) AAAA, even the palindrome AGAAAAGA, is the most hydrophobic core. (3) HIS111 is a residue that plays important roles.(4) The 3 repeated GxxxG motif can inhibit prion infection.(5) The AGAAAAGA palindrome is very interesting to formulate a special ‘cage’ due to its hydrophobic property. Thanks for your attention.

A presentation movie for Elsevier publisher:

Book "Zhang JP (2011) Derivative-free hybrid methods in global optimization and applications – in December 2010, ISBN 978-3-8454-3580-0, 248 pages" is based on PhD thesis (see http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/137122 or http://www.doc88.com/p-241652472799.html)

Supplementary Movies for papers PMID 25373387 & PMID 23563221.

YouTube Video

Figure 4   http://youtu.be/yiIJoxOkrVA     
Figure 5  - http://youtu.be/RXe-wI99FBY      


"Jiapu worked with different people from ITMS which shows that he has very high level interpersonal skills", said by his PhD Supervisor.

Interesting News:
Some reports (in Year 2011) on a Salt Bridge:


Physics Society of Iran (PSI)): http://www.psi.ir/html/news/news/newsletter/90/psinews9007.pdf (pages 44-45)

North American Deer Farmers Association (NADeFA): http://www.nadefa.org/news/prion-disease-secret-immunity-revealed





Some papers were once listed as the TOP25:

SciVerse ScienceDirect TOP25 Hottest Articles, J Theor Biol archive 34: 18.
SciVerse ScienceDirect TOP25 Hottest Articles, J Theor Biol archive 30: 6.

Some papers' figures were once put as the front Journal Cover:

 
Name appears on the Cover of Books/Journals:

………