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education-experiences

Dr. Jiandi Wan

jdween@rit.edu

Microsystems Engineering, Rochester Institute of Technology, Rochester, NY 14623.

Office: 17-2159; Office phone: 585-475-7726

Education

PhD. Boston University, Boston, MA, USA. 2001-2006.

B.S & M.S. Wuhan University, Wuhan, P.  R. China. 1994-2001.

Research Experience

Research Associate, Princeton University. 2009-2012.

Postdoctoral Fellow, Harvard University. 2006-2009.

Professional services

·       Co-chair of the section of rheology and dynamics of complex fluids in the ACS Colloids and Surface Science Symposium, June 2013, Riverside, CA.

·       Editorial board member of the Central European Journal of Engineering, International Journal of Materials and Chemistry, Chemical Rapid Communication, and Soft.

·       Consultant to Harbec, Inc.

·       Visiting Scholar at TsingHua University

·       Reviewer to Journal of the American Chemical Society, Lab on Chip, Advanced Functional Materials, Langmuir, Analytical Chemistry, Soft Matter, Nanoscale, Annals of Biomedical Engineering, Biomicrofluidics, Microfluidics and Nanofluidics, Chemical Communications, Journal of Materials Chemistry, Small, Journal of Colloid and Interface Science, Analyst, Electrophoresis, Journal of Biomedical Optics, Biomedical Optics Express, Applied Surface Science, Journal of Visualized Experiments.

·      Grant proposal review panelist: National Science Foundation (BME, BMMB and IPT programs); Natural Sciences and Engineering Research Council of Canada, ACS Petroleum Research Fund; Wellbeing of Women Foundation UK.


Awards

NSF CBET-1560709, Title “EAGER: An Interfacial Approach to Artificial Red Blood Cells”, Amount: $103,934; Period:  4/15/2016-3/31/2018.

NYSERDA-56679, Title “Development of Microfluidic-based Artificial Leaves for Photocatalytic Carbon Dioxide Reduction”, Amount: $50,000; Period:  3/30/2015-6/30/2016.

ACS PRF-53696-DNI5, Title "Dynamics of the Dissolution of Carbon Dioxide (CO2) Bubbles in Flow and the Formation of Clay-Covered CO2 Emulsions”, Amount: $ 100,000; Period:  01/01/2014-8/31/2016.

2013 Texas Instruments/Douglass Harvey Faculty Development Award

2012 Faculty Education and Development Grant

2010 Faraday Discussion, NSF Fellowship

2005 Feldman Fund Graduate Travel Award


Publications

Publication from RIT (2012-2016)

1.     Huang, Y. S., Delgadillo, L. F., Cyr, K. H., Kingsley, P. D., McGrath, K. E., Waugh, R. E., Wan, J., Palis, J. (2016) Primitive erythroblasts in the fetal circulation assemble a functional cytoskeletal network prior to enucleation. Submitted.

2.     Wei, H., Kang, H., Rasheed, I-Y., Luo, N., Zhou, S., Wang, Y., Richardson, K., Palmer, A., Xu, C., Wan, J., Nedergaard, M. (2016) Erythrocytes are oxygen-sensing regulators of the cerebral microcirculation. submitted.

3.     Piou, M., Fan, R., Darling, E., Cormier, D., Sun, J., Wan. J. (2016) Bioprinting cell-laden Matrigel/agarose constructs. Submitted.

4.     Cyr, K., Huang, Y., Zhou, S., Palis, J., Wan, J. (2016) Microfluidic Assay of the Deformability of Primitive Erythroblasts. Submitted.

5.     Fan, R., Emery, T., Zhang, Y., Xia, Y., Sun, J., Wan, J. (2016) Effect of circulatory shear flow on the viability and proliferation of circulating colon cancer cells. Submitted.

6.     Lu, T., Fan, R., Delgadillo, L., Wan, J. (2016) Stabilization of carbon dioxide (CO2) bubbles in micrometer-diameter aqueous droplets and the formation of hollow microparticles. Lab On Chip. 16, 1587-1592. (Featured as cover article).

7.     Koppula, K. S., Veerapalli, K. R., Fan, R., Wan, J. (2016) Integrated microfluidic system with simultaneous emulsion generation and concentration. J Colloid Interface Sci., 466, 162-167.

8.     Fan, R., Sun, Y., Wan, J. (2015) Leaf-inspired artificial microvascular networks (LIAMN) for 3D cell culture. RSC Advances. 5, 90596-90601.

9.     Cinar, E., Zhou S., DeCourcey, J., Wang, Y., Waugh, R.E., Wan, J. (2015) Piezo1 regulates mechanotransductive release of ATP from human red blood cells. Proc. Nat. Acad. Sci. USA, 112, 11783-11788.

10.  Ge, H. Xu, H., Lu, T., Li, J., Chen, H., Wan, J. (2015) Microfluidic production of porous carbon spheres with tunable size and pores. J Colloid Interface Sci., 461, 168-172.

11.  Wu, S., Yoon, S., Zhang, Y. G., Lu, R., Xia, Y., Wan, J., Petrof, E. O., Claud, E. C., Sun, J. (2015) Vitamin D receptor pathway is required for probiotic protection in colitis. Am J Physiol Gastrointest Liver Physiol. 309, G341-9. 

12.  Fan, R., Naqvi, K., Patel, K.,  Sun, J., Wan, J. (2015) Microfluidic generation of oil-free cell-containing hydrogel particles. Biomicrofluidics. 9, 052602.

13.  Li, J., Wang, Y., Chen, H., Wan, J. (2014) Electrowetting on dielectrics for manipulating oil drops and gas bubbles in aqueous-shell compound drops. Lab on Chip. 14, 4334-4337.

14.  Shim, S., Wan, J., Hilgenfeldt, S., Panchal, P., Stone, H. A. (2014) Dissolution without disappearing: multicomponent gas exchange for CO2 bubbles in a microfluidic channel. Lab on Chip. 14, 2428–2436.

15.  Nunes, J. K., Tsai, S. S. H., Wan, J., Stone, H. A. (2013) Dripping and jetting in microfluidic multiphase flows applied to particle and fiber synthesis. J. Phys. D: Appl. Phys. 46, 114002.

16.  Chen, H., Li, J., Wan, J., Weitz, D. A., and Stone, H. A. (2013) Gas-core triple emulsions for ultrasound triggered release. Soft Matter. 9, 38-42. Cover article.

17.  Tsai, S. S. H., Wexler, J. S., Wan, J, and Stone, H. A. (2013) Microfluidic ultralow interfacial tensiometry by magnetic forcing. Lab on Chip. 13, 119-125.

18.  Wan, J., Shi, L., Benson, B., Bruzek, M. J., Anthony, J. E., Sinko, P. J., Prudhomme, R. K., and Stone H. A. (2012) Microfluidic generation of droplets with a high-loading of nanoparticles. Langmuir. 28, 13143–13148.

19.  Wan, J., (2012) Microfluidic-based synthesis of hydrogel particles for cell microencapsulation and cell-based drug delivery. Polymers, 4, 1084-1108. Invited Review.

 

Previous publications

1.     Forsyth, A. M., Braunmüller, S., Wan, J., Franke, T., Stone, H. A. (2012) The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release. Microvasc Res. 83, 347-351.

2.     Wan, J., and Stone, H. A. (2012) Coated gas bubbles for the continuous synthesis of hollow inorganic particles. Langmuir. 28, 37–41.

3.     Wan, J., Forsyth, A. M., and Stone, H. A. (2011) Red blood cell dynamics: from cell deformation to adenosine-5'-triphosphate release. Integr. Biol. 3, 972-981. Invited Review. 

4.     Tsai, S. S. H., Wexler, J. S., Wan, J, and Stone, H. A. (2011) Conformal coating of particles in microchannels by magnetic forcing. Appl. Phys. Lett. 99, 153509.

5.     Forsyth A. M., Wan, J., Owrutsky, P.D., Abkarian, M., and Stone, H. A. (2011) A multiscale approach to link red blood cell dynamics, shear viscosity, and ATP release. Proc. Nat. Acad. Sci. USA, 108, 10986-10991.

6.     Chen, H., Zhao, Y., Li, J., Guo, M., Wan, J., Weitz, D. A., Stone, H. A. (2011) Reactions in double emulsions by flow-controlled coalescence of encapsulated drops. Lab on Chip. 11, 2312-2315.

7.     Xia, B., Gerard, B., Solano, D.M., Wan, J., Jones, G., Porco, J. A. (2011) ESIPT-mediated photocycloaddtions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening. Org. Lett. 13, 1346–1349.

8.     Subramaniam, A. B., Wan, J., Gopinath, A., and Stone, H. A. (2011) Semipermeable vesicles composed of natural clay. Soft Matter. 7, 2600–2612.

9.     Wan, J., and Stone, H. A. (2010) Microfluidic generation of a high volume fraction of bubbles in droplets. Soft Matter. 6, 4677-4680. Cover article.

10.  Forsyth, A. M., Wan, J., Ristenpart, W. D., and Stone, H. A. (2010) The dynamic behavior of chemically “stiffened” red blood cells in microchannel flows. Microvasc Res.  80, 37-43.

11.  Wan, J., Thomas, M., and Vullev, V. I. (2009) Surface bound proteins with preserved functionality. Ann. Biomed. Eng. 37, 1190-1205.

12.  Hu, J., Xia, B., Bao, D., Ferreira, A., Wan, J., Jones II, G., and Vullev, V. I. (2009) Long-lived photogenerated states of α-oligothiophene-acridinium dyads have triplet character. J. Phys. Chem. A, 113, 3096-3107.

13.  Stone, H.A., Forsyth, A. M., and Wan, J. (2009) Slipping through blood flow. Physics, 2, 89.

14.  Wan, J., Ristenpart, W. D., and Stone, H. A. (2008) Dynamics of shear-induced ATP release from red blood cells. Proc. Nat. Acad. Sci. USA. 105, 16432-16437.

15.  Wan, J., Bick, A., Sullivan, M., and Stone, H. A. (2008) Controllable microfluidic production of microbubbles in water-in-oil emulsions and the formation of porous microparticles. Adv. Mater. 20, 3314-3318.

16.  Wan, J., Ferreira, A., Xia, W., Chow, C. H., Takechi, K., Kamat, P. V., Jones II, G., and Vullev, V. I. (2008) Solvent dependence of the charge-transfer properties of a quaterthiophene-anthraquinone dyad. J. Photochem. Photobiol. A: Chem. 197, 364-374.

17.  Ristenpart, W. D., Wan, J., and Stone, H. A. (2008) Enzymatic reactions in microfluidic devices. Anal. Chem. 80, 3270-3276.

18.  Ristenpart, W. D., Kim, P. G., Donmingues, C., Wan, J., and Stone, H. A. (2007) Influence of substrate conductivity on circulation reversal in evaporating drops. Phys. Rev. Lett. 99, 234502.

19.  Jones II, G., Yan, D., Hu, J., Wan, J., Xia, B., and Vullev, V. I. (2007) Photoinduced electron transfer in arylacridinium conjugates in a solid glass matrix. J. Phys. Chem. B, 111, 6921 – 6929.

20.  Vullev, V. I., Wan, J., Heinrich, V., Landsman, P., Bower, P. E., Xia, B.,  Millare, B., and Jones II, G. (2006) Nonlithographic fabrication of microfluidic devices. J. Am. Chem.  Soc. 128, 16062-16072.

21.  Gartner, C. A., Wen, B., Wan, J., Becker, R. S., Jones II, G., Gygi, S. P., and Nelson, S. D. (2005) Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4. Biochemistry, 44, 1846-1855.

22.  Wan, J., Feng, Y., Hu, Y., Da, S., and Wang, Z. (2002) Preparation and evaluation of 2, 4, 6-trinitrophenol-modified zirconia-alumina for high performance liquid chromatography and its application in the separation of fullerenes. Chemical Journal of Chinese Universities-Chinese, 23, 1259-1263.

23.  Hu, Y., Feng, Y., Wan, J., and Da, S. (2002) Comparison of Lewis acid modified mixed-oxide as chromatographic packings in reversed-phase chromatography. J. Liq. Chrom. & Rel. Technol., 25, 83-99.

24.  Hu, Y., Feng, Y., Wan, J., Da, S., and Hu, L. (2001) Native and stearic acid modified ceria-zirconia supports in normal and reversed-phase HPLC. Talanta, 54, 79-88.

25.  Wan, J., Feng, Y., Hu, Y., Da, S., and Wang, Z. (2001) Preparation and evaluation of zirconia-alumina composites for high performance liquid chromatography. Chin. J. Anal. Chem.-Chinese 29, 802-805.

26.  Wan, J., Feng, Y., Hu, Yu., Da, S., and Wang, Z. (2001) Preparation and evaluation of acid-corroded zirconia-alumina composites as HPLC support. Journal of Analytical Science-Chinese. 17, 371-374.

27.  Wan, J., Feng, Y., Hu, Y., Da, S., and Wang, Z. (2001) Preparation of mesopore zirconia-alumina composite and its application to normal HPLC support. Chemical Journal of Chinese Universities-Chinese, 22, 1661-1663.

 

Patents

1.     Tsai, S., Wexler, J. S., Wan, J., Stone, H. A. (2011) Microparticle conformal coating technology on a chip. US Patent. in application

2.     Forsyth, A., Wan, J., Kim, S., Tariq, A., Boehlert, J., Tsai, S., Persaud, N., Stone, H. A. (2011) Lab safety and information technology. US Patent. in application

3.     Wan, J., Stone, H. A. (2011). Microbubble-templated synthesis of hollow inorganic Particles.  US Patent. in application.

4.     Prud'homme, R., Sinko, P. J., Stone, H. A., Pinkerton, N. M.., Shi, L., Wan, J., Ibrahim, S. and Gao, D. (2010) Lung Targeting Dual Drug Delivery System. US Patent. in application.

5.     Stone, H. A., Wan, J. and Sullivan, M. (2008). Formation of particles for ultrasound applications, drug release, and other uses, and microfluidic methods of preparation. US Patent, in application.

6.     Stone, H. A., Ristenpart, W. D. and Wan, J. (2008). Reaction within microfluidic channels. US Patent. In application.

7.     Feng, Y., Da, S.,  Hu, Y. and Wan, J. (2002). Phenol-modified inorganic oxide composite as stationary phase of liquid Chromatography: its preparation and application Faming Zhuanli Shenqing Gongkai Shuomingshu   Patent  written in Chinese. Application: CN 2002-115835 20020514.

 

Conference Presentations and Proceedings

 

1.     “Red cell dynamics” The 68th Annual Meeting of the American Physical Society's Division of Fluid Dynamics, Boston, MA. November 22-24, 2015.

2.     “Piezo1 regulates shear-induced ATP release from human red blood cells” Red Cell  Club Fall 2014 Meeting, Toronto, Canada, September 19th-20th, 2014.

3.      “Mechanosensing dynamics of human RBCs” Red Cell Club meeting, New York Blood Center, NY. October 4 – 5, 2013.

4.      “Dynamics of emulsions and drops in microfluidicsGordon Research Conference, Microfluidics, Physics & Chemistry, Lucca, Italy. June 9-14, 2013.

5.     “Mechanotransductive release of ATP from RBCs” Gordon Research Conference, Red Cell,  Proctor Academy, Andover, NH. July 7-12, 2013.

6.      “Microfluidic studies of red blood cell dynamics and microemulsions” The 86th ACS Colloid & Surface Science Symposium. Johns Hopkins University, Baltimore, Maryland. June 10-13th, 2012.

7.     “Dynamics of red blood cells: from mechanosensing to effective blood viscosity” Gordon Research Conference, Bioanalytical Sensors, Salve Regina University, Newport, RI. June 17-22, 2012.

8.      “Solvent dependence of the charge-transfer properties of a quaterthiophene-anthraquinone dyad” Gordon Research Conference, Electron donor-acceptor interactions. Newport, Rhode Island, August 3, 2010.

9.     “Surface-bound proteins with preserved functionality” NSF/ACS Fellowship for Faraday Discussion 146.  Richmond, Virginia, April 9, 2010.

10.  “Controllable microfluidic production of microbubbles in water-in-oil emulsions and the formation of porous microparticles” Partnerships for Research and Education in Materials (PREM) Workshop, School of Engineering and Applied Sciences, Harvard University.  June 24, 2009; AIChE Annual Meeting, Philadelphia, PA, November 18, 2008.

11.   “Generation of Mono-dispersed oil/water/gas Emulsions in Microfluidic System” Shenyang International Colloquium on Microfluidics, Shenyang, China, October 23, 2007.

12.  “A Microfluidic Approach for Studying Shear-induced ATP Release Kinetics from Red Blood Cells” APS-DFD Meeting, Salt Lake City, November 19, 2007; AIChE Annual Meeting, Salt Lake City, November 8, 2007.

13.   “Novel, simple and efficient procedure for immobilization of proteins on glass-type surfaces” Feldman Fund Graduate Travel Award for 230th ACS national meeting, Washington DC, August 31, 2005.

14.  Wan, J., Sullivan, M., and Stone, H. A. (2007) Controllable production of gas/water/oil double emulsions in microfluidic devices. Proceedings of the First Shenyang International Colloquium on Microfluidics. 213-214.

15.  Thomas, M., Wan, J., and Vullev, V. I. (2007) Biofunctionalization of silica-based substrates.  Lamego, 21-23.

16.  Wan, J., Landsman, P., Xia, B., Bower, P., Heinrich, V., Jones II, G., and Vullev, V. I. (2006) Continuous-flow microfluidic devices for detection of bacterial endospores.  Proc. NanoBio, 5, 1.

 

Invited talks

1.     “Microfluidic approach for red blood cells” The Microfluidics and Interfaces Workshop at TsingHua University, Beijing, August 21, 2015

2.     “Dynamics of Red blood cells”. The 10th Ontario-on-a-chip Symposium at University of Toronto. May 28-29, 2015

3.     “Mechanosensing dynamics of red blood cells and microfluidic-based encapsulation”. Department of Biomedical Engineering, University of Rochester. February 4, 2014.

4.     “Microfluidics: Application to lung biology and blood cell research”. The Lung Biology and Disease Program, University of Rochester Medical Center. October 15, 2013.

5.     “Microfluidic studies of the dynamics of red blood cells and microbubble emulsions” Department of Chemical Engineering, University of Rochester. October 10, 2012.

6.     “Quantitative and integrative microfluidic studies of vascular signaling dynamics and microbubble emulsions” Department of Mechanical Engineering, the State University of New York at Binghamton. April 26, 2012.

7.      “Probing the cellular dynamics: a microfluidic study of ATP release from red blood cells” Squishy Physics, Harvard University. September 9, 2009.

 

In the News

1.     Clay-armored bubbles may have formed first protocells. Harvard SEAS news: http://www.seas.harvard.edu/news-events/press-releases/clay-armored-bubbles. Harvard University Gazette news: http://news.harvard.edu/gazette/story/2011/02/clues-in-clay/?sms_ss=email&at_xt=4d5a9a86207f9172%2C0. MIT Technology Review, Harvard Gazette, Harvard Crimson, Pour la Science (French Scientific American), Physorg.com.

2.     Controllable microfluidic production of microbubbles in water-in-oil emulsions and the formation of porous microparticles. Harvard Magazine: The Harvard Center for Gastrophysics. March - April 2009,13-14.

3.     Study Shines Light on How Red Blood Cells Control Blood Pressure. UC Davis news and information: http://www.news.ucdavis.edu/search/news_detail.lasso?id=8836

4.     Print-and-Peel Method Creates Microfluidic Devices. Nanotech News from National Cancer Institute: http://nano.cancer.gov/news_center/nanotech_news_2006-12-04d.asp

5.     Developing Biofunctional Glass Coatings. BMES Bulletin, Biomedical Engineering Society Newspaper: 2007, 31, 16-17.tin, Biomedical Engineering Society Newspaper: 2007, 31, 16-17.