Principal Investigator

Dr. Jiandi Wan

Assistant Professor
Microsystems Engineering
Rochester Institute of Technology (RIT)
Rochester, NY, 14623

Adjunct Assistant Professor
Center for Translational Neuromedicine
University of Rochester
Medical Center (URMC)

(CV)

Office: 17-2159 (RIT)                             1.9639 (URMC)

Phone: 585-475-7726 (RIT)
           585-273-4681 (URMC)
            
Email: jdween@rit.edu
jiandi_wan@urmc.rochester.edu


PhD., Boston University
Postdoctoral, Harvard University
Research Associate, Princeton University
 

Welcome to the WAN Research Group

The broad objective of my research is to explore microscale multiphase flows in biology, tissue engineering, and materials. In particular, my lab develops novel ex vivo microfluidic approaches and combine in vivo multiphoton microscopy to investigate emerging challenges in brain physiology including capillary blood flow, neurovascular coupling, and cerebrospinal fluids. We explore stem cell biology and long-term 3D cell culture systems to develop Organ-on-a-Chip devices. We further combine interfacial dynamics and fluid dynamics in microfluidics with material science and engineering to investigate the synthesis of advanced functional materials. The ultimate goals of my research are to advance our fundamental understanding of multiphase fluid dynamics in these fields and provide ground-breaking technologies, devices, and materials for biomedical therapeutics and applications in energy technology. 

Select Publications

  1. Fan, R., Chen, X., Wang, Z., Custer, D., Wan, J. (2017) Flow-regulated growth of titanium dioxide (TiO2) nanotubes in microfluidics. Small, in press. (Featured as a frontispiece article).
  2.  Wei, H., Kang, H., Rasheed, I-Y., Luo, N., Zhou, S., Wang, Y., Richardson, K., Palmer, A., Xu, C.,       Wan, J., Nedergaard, M. (2016) Erythrocytes are oxygen-sensing regulators of the cerebral microcirculation. Neuron, 91, 851-862. 
  3. Fan, R., Emery, T., Zhang, Y., Xia, Y., Sun, J., Wan, J. (2016) Effect of circulatory shear flow on the viability and proliferation of circulating colon cancer cells.  Sci. Rep. 6, 27073.
  4.  Lu, T., Fan, R., Delgadillo, L., Wan, J. (2016) Stabilization of carbon dioxide (CO2) bubbles in micrometer-diameter aqueous droplets and the formation of hollow microparticles. Lab On Chip. 16, 1587-1592. (Featured as cover article).
  5. Cinar, E., Zhou S., DeCourcey, J., Wang, Y., Waugh, R.E., Wan, J. (2015) Piezo1 regulates mechanotransductive release of ATP from human red blood cells. Proc. Nat. Acad. Sci. USA, 112, 11783-11788.
  6. Fan, R., Sun, Y., Wan, J. (2015) Leaf-inspired artificial microvascular networks (LIAMN) for 3D cell culture. RSC Advances. 5, 90596-9060
  7. Forsyth A. M., Wan, J., Owrutsky, P.D., Abkarian, M., and Stone, H. A. (2011) A multiscale approach to link red blood cell dynamics, shear viscosity, and ATP release. Proc. Nat. Acad. Sci. USA, 108, 10986-10991.
  8. Wan, J., Forsyth, A. M., and Stone, H. A. (2011) Red blood cell dynamics: from cell deformation to adenosine-5'-triphosphate release. Integr. Biol. 3, 972-981.
  9. Wan, J., Ristenpart, W. D., and Stone, H. A. (2008) Dynamics of shear-induced ATP release from red blood cells. Proc. Nat. Acad. Sci. USA. 105, 16432-16437.
  10. Wan, J., and Stone, H. A. (2010) Microfluidic generation of a high volume fraction of bubbles in droplets. Soft Matter. 6, 4677-4680. Cover Story.
  11. Wan, J., Bick, A., Sullivan, M., and Stone, H. A. (2008) Controllable microfluidic production of microbubbles in water-in-oil emulsions and the formation of porous microparticles. Adv. Mater. 20, 3314-3318.
  12. Vullev, V. I., Wan, J., Heinrich, V., Landsman, P., Bower, P. E., Xia, B.,  Millare, B., and Jones II, G. (2006) Nonlithographic fabrication of microfluidic devices. J. Am. Chem.  Soc. 128, 16062-16072
  


Bubbles in droplet


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