JFA Jansen, Ph.D.
Curriculum Vitae

Curriculum Vitae

For my PhD thesis, I investigated the use of magnetic resonance (MR) techniques for epilepsy-related brain abnormalities of metabolism, microstructures and function. The research project was aimed at developing and validating several quantitative MR techniques with clinical diagnostic potential, including: spectroscopy, diffusion, T2 relaxometry, and functional magnetic resonance imaging. The main focus was on data acquisition and processing, and the application of this multi-parametric MR approach in both epilepsy patients and an animal model of epileptogenesis. In a clinical setting I investigated how the cognitive consequences of epilepsy (either due to medication or due to seizures) may be reflected in altered MR tissue characteristics. Furthermore, using an experimental model of febrile convulsions, I investigated whether neurological abnormalities, possibly linked with epileptogenesis, could be detected by quantitative MR.

For my first postdoctoral fellowship at Epilepsy Center Kempenhaeghe, I investigated the neuronal basis of cognitive deficits in patients with cryptogenic epilepsy using functional and structural connectivity MRI measurements. Additionally, I developed an automated segmentation algorithm for the delineation of white matter lesions on FLAIR images.

For my postdoctoral fellowship at the Memorial Sloan-Kettering Cancer Center, I studied patients with head and neck cancer. My research was aimed at 1) aiding the diagnosis by exploring the synergy between several quantitative MR (diffusion, perfusion and, spectroscopy) and PET measurements, and 2) investigating the predictive value of these techniques.

Currently I am working as Assistant Professor at the department of Radiology at the Maastricht University Medical Center and at the School for Mental Health and Neuroscience of Maastricht University, where I continue to apply quantitative MR techniques in a clinical setting, e.g. patients with epilepsy and diabetes mellitus type II. In particular I am interested in the relationship of cognitive decline with MR biomarkers in these patients groups. In November 2010, I was awarded the prestigious VENI grant for researching cognitive decline in diabetes mellitus type II. I also focus on newer data analysis techniques to study functional and structural connectivity, and network characteristics of the brain.    

Meanwhile, I still proactively collaborate with the head and neck oncological imaging research group at MSKCC.

Summary:

  • Assistant Professor: School for Mental Health and Neuroscience, Maastricht University (2013-)
  • Faculty: Maastricht University Medical Center, Maastricht, The Netherlands (2010-)
  • Postdoctoral Fellow/Research Scholar: Memorial Sloan-Kettering Cancer Center, New York, USA (2008-2010)
  • Postdoctoral Fellow: Maastricht University Hospital / Epilepsy Centre Kempenhaeghe, The Netherlands (2007-2008)
  • Ph.D. in Biomedical Engineering: Eindhoven University of Technology / Maastricht University Hospital, The Netherlands (2002-2007)
  • Undergraduate exchange student: Johns Hopkins University School of Medicine, Baltimore, USA (2001-2002)
  • M.Sc. in Chemistry from Radboud University, Nijmegen, The Netherlands (1997-2002)

Scientific and Medical Societies

1997-present    Royal Netherlands Chemical Society (KNCV)
2002-present    International Society for Magnetic Resonance in Medicine
2009-2010        New York Academy of Sciences
 
 

Editorial Boards

2012- present   Member Editorial Board, ISRN Radiology
2006- present   Journal Reviewer, Investigative Radiology
2006- present   Journal Reviewer, Seizure - European Journal of Epilepsy
2006- present   Journal Reviewer, Epilepsy & Behavior
2008- present   Journal Reviewer, Neuroimage
2009- present   Journal Reviewer, Neurological Sciences
2010- present   Journal Reviewer, Recent Patents on Inflammation & Allergy Drug
Discovery
2010- present   Journal Reviewer, Medical Physics
2010- present   Journal Reviewer, Radiology Research and Practice
2011- present   Journal Reviewer, Journal of Neurology, Neurosurgery & Psychiatry
2011- present   Journal Reviewer, Physica Medica: European Journal of Medical Physics
2011- present   Journal Reviewer, Epilepsia
2012- present   Journal Reviewer, Epilepsie: periodiek voor professionals
2012- present   Journal Reviewer, European Journal of Neurology
2012- present   Journal Reviewer, Trends in Biotechnology
2012- present   Journal Reviewer, Oral Oncology
2012- present   Journal Reviewer, European Radiology
2013- present   Journal Reviewer, Magnetic Resonance in Medicine
2013- present   Journal Reviewer, International Journal of Developmental Neuroscience
2013- present   Journal Reviewer, Journal of Magnetic Resonance Imaging
2013- present   Journal Reviewer, BMJ Open
2013- present   Journal Reviewer, Progress in Neuro-Psychopharmacology & Biological Psychiatry
2013- present   Journal Reviewer, Magnetic Resonance Imaging
2013- present   Journal Reviewer, Neuroscience & Biobehavioral Reviews
    2007
  • Grant Reviewer: Innovational Research Incentives Scheme VIDI, Netherlands Organization for Scientific Research

  • 2007
  • Grant Reviewer: Tinnitus Research Initiative, USA

  • 2010, 2013
  • Abstract Reviewer, ISMRM

  • 2011, 2012, 2013
  • Abstract Reviewer, ISMRM BeNeLux

  • 2010, 2011
  • Grant Reviewer: ZonMw's 'Health Care Efficiency Research Programme Early Evaluation of Medical Innovation', The Netherlands

  • 2011
  • Grant Reviewer, Integrated Research Action Programme, Upper Aerodigestive Tract Cancers, France

  • 2012
  • Grant Reviewer: Innovational Research Incentives VENI, Netherlands Organization for Scientific Research

 

Research Support

2010     NWO Innovational Research Incentives Scheme Veni
Project ‘Functional MRI biomarkers of cognitive decrements in diabetes’
Role: PI
 
2010     Nationaal MS Fonds (Netherlands MS Foundation)
Project ‘Impact of vitamin D on neuropsychological and functional MRI outcome measures of cognition in patients with multiple sclerosis’
Role: Co-investigator and co-writer (PI: R. Hupperts)
 
2009     Prevent Cancer Foundation Fellowship
Project ‘Transferrin based molecular imaging for the early detection of oral cancer’
Role: PI
 
2009     KWF (Dutch Cancer Society) fellowship for fundamental and (pre)clinical cancer research
Project ‘The assessment of oncogenesis in an animal model using nanoparticle molecular imaging’
Role: PI
N.B.: This grant is specifically intended for postdoctoral fellows performing research abroad; therefore I declined it due to my relocation to the Netherlands in 2010.
 
2006     Dutch National Epilepsy Foundation: grant NEF 06-02
Project ‘Neuronal factors of cognitive impairment in patients with localization-related epilepsy: a multi-modal MRI study’
Role: Co-investigator and co-writer (PI: W.H. Backes)
 

Awards

2002    Foreign Internship Grant for Undergraduate Students (KWF; Dutch Cancer Society)
2002    Educational Stipend for Students and Postdoctoral Trainees, ISMRM Hawaii
2004    Fellinga Travel Grant, KNCV (Royal Netherlands Chemical Society)
2005    Educational Stipend for Students and Postdoctoral Trainees, ISMRM Miami
2006    Educational Stipend for Students and Postdoctoral Trainees, ISMRM Seattle
2006    Travel Bursary Award, 7th European Congress on Epileptology, Helsinki
2007    Financial support for printing of dissertation:
Van Leersum Fonds, het Nationaal Epilepsie Fonds, Kempenhaeghe Sector for Research and Development, UCB Pharma, Kodak, Guerbet, and the CODICE research group
 
 

Prizes

2001    Finalist, PAC / KNCV (Royal Netherlands Chemical Society) undergraduate student poster contest, Leiden, The Netherlands.
2007    Young Investigators’ Award, 27th International Epilepsy Congress, Singapore
2009    Finalist, ISMRM Neuroimaging poster contest, Honolulu, Hawaii, USA
 
 

Administrative Experiences

1999-2000 Member chemistry study tour committee 2000
1999-2000 Treasurer Chemistry Students' club V.V.C.N. Sigma
1998-1999 Member Board Chemistry Students' club V.V.C.N. Sigma
1997-2001 Member several committees of V.V.C.N. Sigma
1998-2002 Regular participant promotional activities Chemistry Nijmegen
1998-2000 Junior reporter (Student correspondent) biweekly magazine KNCV (Royal Netherlands Chemical Society)
1998-2007 Design and maintenance website “Redtband” orchestra
1999-2008 Member Treasurer Review Committee various organizations
 
 

Theses

4/2002
The mSin3B-PAH2 and hMad1-SID interaction investigated by high resolution NMR. (M.Sc.) Radboud University Nijmegen, The Netherlands
 
6/2002
MR studies of stem cells. (M.Sc.) Radboud University Nijmegen, The Netherlands
 
3/2002
Literature study: Adiabatic Pulses. (M.Sc.) Radboud University Nijmegen, The Netherlands
 
5/2007
Quantitative Magnetic Resonance Techniques in Epilepsy. (Ph.D.) Eindhoven University of Technology, The Netherlands
 
 

Certificates

I have been awarded with these certificates emphasizing my capability of performing clinical research in a responsible manner, and how to work responsibly and safely with ionizing radiation, radioactive substances and radiation emitting equipment.
 
12/2009
Certificate of Completion of the Responsible Conduct of Research Course at the Memorial Sloan-Kettering Cancer Center.
 
11/2010
Certificate of passing the Good Clinical Practice Exam at the Maastricht University Medical center.
 
11/2011
Certificate of passing the Radiation Protection Experts Level 3 Exam at the School of Medical Physics and Engineering Eindhoven (SMPE/e), Eindhoven University of Technology (TU/e).
 

Media Attention

In 2007 I had several interviews (in Dutch) to celebrate the publication of my Ph.D. thesis.
Eindhoven Univeristy of Technology press release.
Eindhoven Univeristy of Technology interview in 'cursor' news paper.
Omroep Brabant radio interview.
Episcoop magazine for patients with epilepsy, interview.

In August 2009, the MSKCC Research Weekly newsletter highlighted my prevent cancer foundation award.

Following our Neurology publication in October 2010, the Maastricht based website 'Maastricht Aktueel' ran a story of my colleague Marielle Vlooswijk and me (in dutch).

In November 2010, the 'Observant', which is the local magazine of the Maastricht university, reported on my VENI grant (in dutch).

In 2011, a book came out, titled "Conversations with Academics: Secrets of Promising PhD Scholars Revealed", for which I was interviewed about my PhD project. The author found me through my website, and thought I was a good example of a "promising scholar". The book can be purchased through Amazon.com, which also offers a brief preview of my chapter ("Search inside this Book": Jacobus).


Fun Fact

My most important contribution to science was with my brain, but unfortunately not an intellectual contribution. As an undergrad student at Johns Hopkins in Baltimore in 2001, my friend Hanzhang Lu asked me to be a volunteer for his fMRI study. My brain response was not as he expected, and as a result, VASO was born, which is still very popular these days. He recently wrote a review about it, and although he does not mention my name, the 22 year old male volunteer is me!
 
By Hanzhang Lu and Peter C.M. van Zijl
Neuroimage. 2012 Jan 8. [Epub ahead of print]
An unexpected finding which led to the conjecture of CBV-based fMRI
 
"We did our first, at that time called IR-fMRI, experiment on a 22 year old male volunteer on October 10, 2001. ... Despite these interesting findings and potential possibility of a new brain mapping mechanism, the time course in Fig. 1b was very noisy and far from conclusive. ... After many rounds of discussion among the authors of this review and our colleagues Xavier Golay and Jim Pekar, we decided to baptize this technique “Vascular-Space-Occupancy” or “VASO” fMRI. "