JFA Jansen, Ph.D.


Jaap Jansen

Jacobus (Jaap) Franciscus Antonius Jansen was born on July 4th 1979 in Oirschot, The Netherlands. He studied Chemistry at the Radboud University Nijmegen, where he obtained his M.Sc. degree in Chemistry in 2002. He did his major in Biophysical Chemistry at the Laboratory of Biophysical Chemistry of the University of Nijmegen of the Radboud University Nijmegen, under the supervision of Dr. G.W. Vuister and Prof. Dr. C.W. Hilbers on the study of the structure, mobility, and function of proteins using high resolution nuclear magnetic resonance (NMR) spectroscopy. His minor in Biomedical NMR was done at two institutes. In the Department of Radiology, Radboud University Nijmegen Medical Centre, he was involved in the elucidation of murine muscle energy metabolism using phosphorous NMR spectroscopy, under the supervision of Prof. Dr. A. Heerschap. At the Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, USA, he used NMR techniques to study stem cells, which was supervised by Dr. J.M. Hakumaki, Prof. Dr. J.W.M. Bulte, and Prof. Dr. P.C.M. van Zijl.

In September 2002 he started his Ph.D. project in the group Biomedical NMR of the department of Biomedical Engineering of the Technical University of Eindhoven (TU/e) and at the department of Radiology at the Maastricht University Hospital (azM). This research project concerned quantitative MR techniques in epilepsy, and was under supervision of Prof. Dr. K. Nicolay (TU/e), Dr. W.H. Backes (azM), and Dr. M.E. Kooi (azM). June 7th 2007, he defended his thesis "Quantitative Magnetic Resonance Techniques in Epilepsy" at the Technical University of Eindhoven and obtained his Ph.D.

From April 2007 until April 2008, he was appointed as a Postdoc within the epilepsy center Kempenhaeghe and the departments of Radiology and Neurology in the Maastricht University Hospital. Within the framework of the collaboration of these institutes he was working on the development and application of quantitative MR techniques in epilepsy research.

On May 2008, he was appointed as a Research Fellow within the Memorial Sloan-Kettering Cancer Center. He worked in the group of Dr J.A. Koutcher and Dr A. Shukla-Dave, and used quantitative MR techniques (1H-MRS, DCE MRI, and DWI) in patients with head/neck cancer.

On June 1st 2010, he started as faculty at the department of Radiology at the Maastricht University Medical Center. In November 2010, he was awarded the prestigious VENI grant for researching cognitive decline in diabetes mellitus type II. On January 1st 2013, he became Assistant Professor at the School for Mental Health and Neuroscience, Maastricht University. In Maastricht, he initiated the neuroimaging research lines of diabetes mellitus type II (VENI grant) and psychogenic non-epileptic seizures (collaboration Kempenhaeghe / Ghent University Hospital). Moreover, he commenced neurotransmitter MR spectroscopy in epilepsy, diabetes, and autism. Furthermore, his research is focused on the development and application of novel MRI techniques to study blood brain barrier dysfunction in Alzheimer’s Disease and cerebral Small Vessel Disease. One of these techniques is intravoxel incoherent motion (IVIM) imaging, which allows the simultaneous assessment of microvasculature and parenchymal microstructure.

Meanwhile, he still proactively collaborates with Memorial Sloan-Kettering Cancer Center.