Jeremy Horst Keeper DDS, PhD is a dentist & scientist in San Francisco.
My primary career goal is to reduce suffering from dental caries by validating and scaling innovations in care for oral health generally and dental caries specifically. We have information and tools that could tremendously improve oral health for all, which complement the existing system of dentistry by activating non-dentists to assess and manage dental diseases, and by empowering people to care for themselves. To reach these goals I have focused on bringing up scalable solutions and have been successful with silver diamine fluoride (SDF), glass ionomer cements (GICs), and Curodont Repair. This journey has been fueled by life-long learning from the literature, tradition, patients, colleagues, and experimentation in the laboratory and clinic. This has manifested as 25 years in oral health care as a dental assistant, free clinic director, general dentist, pediatric dentist, scientist with over 45 publications, educator having taught over 400 continuing dental education courses, and director in a corporate environment.
Key Accomplishments
Co-led introduction of SDF into the US.
Created medical CPT code for SDF.
Wrote successful proposal to add GIC to the WHO Lists of Essential Medicines.
Co-invented no-excavation SMART fillings, using SDF to finesse needles and drills.
Co-led introduction of Curodont into the US.
Created dental CDT code for tooth hydroxyapatite regeneration.
Conceived dental povidone-iodine product for caries prevention.
Re-discovered that feline calicivirus causes feline gingivostomatitis, and discovered that foamy virus causes the treatment-resistant form of the disease.
Re-discovered that vitamin B6 prevents tooth decay.
In his research with the DeRisi lab at UCSF and the Samudrala group, now at SUNY Buffalo he applied genome-wide analyses to the bacteria that cause dental caries, to inform drug discovery to prevent and stop dental caries. His automated analyses rediscovered that a form of vitamin B stops acid production by caries bacteria, and sprouted many other leads. His analyses have also led to the discoveries of the genetic reasons for various birth defects, and mechanisms of drug resistance for infectious diseases such as malaria.
See all Jeremy's publications here, and citation tracking here.
See Jeremy's pre-publication manuscripts here.
See Jeremy's YouTube videos here.
He also invented OraViz, a cloud-computing 3D dental imaging technology using equipment already in most dental clinics.
Educationally, he attended:
Breakthrough SummerBridge
SF University High Shool
UC San Diego (MS Chemistry, BS Pharm Chem, BA Psychology)
UWashington (DDS, PhD Oral Biology)
UCSF (Pediatric Dentistry, Postdocs in Integrative Structural Biology and Infectious Disease Biochemistry)
Clinically, he ran the UC San Diego free dental clinics, and
practiced with the UW Dental Fears Research clinic,
taught in the UW Dental Urgent Care Clinic,
and practiced in pediatric dental clinics around San Francisco including Life of Smiles,
Mentors:
Postdoc: Joe DeRisi, Peter Milgrom, Pam DenBesten, Andrej Sali, John Featherstone
PhD: Ram Samudrala, Martha Somerman, Sue Herring, Malcolm Snead, Michael Cunningham
Clinical: Steve Pickering, Thuan Le, Dorothy Pang, Peter Milgrom, David Perry
NOTE: If you are looking for slides from a conference presentation, and you do not see the link at left, email me: jahorst@gmail.com
Jeremy believes that has been and may continue to be a member of the following organizations: