I have lived in Vancouver, Canada; Seattle, Washington; Cambridge, England; Buerchen, Switzerland; La Jolla, Davis, San Jose, and Fresno, California.
Whenever time is allowed, I enjoy hiking with my husband and daughter in Burchen, Switzerland, Cypress mountain, Vancouver, Canada, and Torrey Pine State Reverse Park, La Jolla, California. I also love cooking for my family and friends in the weekend. I really like recipes from "the BBC website" and the two best British chefs-- Heston Blumenthal and Marco Pierre White. I hope that my daughter would grow up quickly so we could go dancing ballet together. She can do the split now!
Mt. Cypress, Vancouver, Canada
My Curriculum Vitae
If you're applying for fellowships/grants and need my CV, please change the following NIH biographical sketch to fit your needs. Please also go to the pubmed for updated publications.
NIH biographical sketch
Bui, Jennifer M.
Assistant Research Professor
eRA COMMONS USER NAME
(credential, e.g., agency login)
EDUCATION/TRAINING (Begin with baccalaureate or other
initial professional education, such as nursing, and include postdoctoral
INSTITUTION AND LOCATION
FIELD OF STUDY
University of Washington, Seattle
University of California, San Diego
University of California, Davis
Please refer to the application instructions in
order to complete sections A, B, and C of the Biographical Sketch.
I have been conducting research that
focuses on fundamental scientific understanding, method development and
also, applications in medicine using protein structure, chemical information,
and protein engineering
with world-renown protein scientists at the best ranking institutions in the
world. I have adept knowledge of chemistry and biology, outstanding
computational skills, and well-developed mathematical abilities to carry out
the proposed research from different angles.
These reflect on my publication record (below) with a gap period when I took one year of maternity and
parenting leave (02/2010- 02/2011).
2012- Assistant Research Scientist, University of California,
2013- Adjunct Assistant Professor in Faculty of Pharmaceutical Sciences, University of British
2010 NIEHS K01 NIH career development grant.
2007-2009 Junior Research
Fellow of Hughes Hall, a royal charter of University of Cambridge, UK.
Institutes of Health Ruth L. Kirschstein/NRSA Postdoctoral Fellowship,
University of Cambridge, UK
2006-2009 National Science Foundation Postdoctoral Research Fellowship in
Biological Informatics, University of Cambridge, UK.
2007 The ISN/ IBRO fellowship, the IXth International Meeting on Cholinesterases.
2004 The Army Medical Defense Command travel
award to participate in
the VIIIth International Meeting on Cholinesterases.
2003-2006 Trainee, NSF Center
for Theoretical Biological Physics,UC-San Diego
Trainee, NIH Molecular Biophysics Training Grant, UC-San Diego
Trainee, NSF Institute of Theoretical Dynamics Training Grant, UC-Davis
1997 University of California Regents: The
Bradford Borge Graduate Fellowship, UC-Davis
1997 Departmental Citation for the most
meritorious undergraduate achievement, UC-Davis
Chemical Scholarship, UC-Davis
1996 The Dean's
List of College of Letters and Science,
· Junior Fellow, Hughes Hall,
University of Cambridge (2007-2009)
Biophysical Society Meeting Platform, Baltimore
Referee for Proteins: Structure,
Function and Bioinformatics , Biophysical,
· Member of American
Chemical Society (2004), Biophysical
Society (2002), of Protein Society (2002)
· Elected Member, Phi
Kappa Phi Honors Society (1996-present)
February 14-18, 2004
“Conformational Variations of
Fasciculin Associated with Protein-Protein Binding Interaction”, presented at
the Biophysical Society 8thAnnual
Meeting, Baltimore, Maryland.
March 25-April 1, 2004
Variations of Fasciculin Associated with Protein-Protein Binding
Interaction”, presented at the 228th
American Chemical Society
National Meeting, Anaheim, California.
June 3-5, 2005
“Computational Modeling of Biomolecules: The Roles of
Dynamics in Acetylcholinesterase Activity and Inhibition”, presented at the 6th
VACETS Technical International Conference, Milpitas, California.
September 10-14, 2006
“Protein binding mechanism: Fast induced-fit
conformational transitions of neurotoxin Fasciculin-2 in complex with
acetylcholinesterase”, presented at 232nd
American Chemical Society National Meeting, San Francisco, California.
August 19-23, 2007
February 1-6, 2008
“Caught in atomistic detailed action: Modeling of protein-G monomers forming
oligomers”, presented at 234nd American Chemical Society National Meeting, Boston, Massachusetts.
“The Dynamics Energy Landscape Capturing Conformational
Population Shift in Oligomerization, presented at the Biophysical Society 52nd Annual Meeting & the 16th
International Biophysics Congress.
C. Peer-Reviewed Publications
· Jennifer M. Bui and David Baker. Computational Scheme Accounted
for Receptor Flexibility in Rosetta-Ligand Docking, submitted, Journal
of Computer-Aided Molecular Design, 2012
· Jennifer M. Bui and David Baker. Screening for a New Class of Allosteric
Inhibitors to Human Ubiquitin Conjugating Enzymes E2, submitted, Journal of
Molecular Biology, 2012.
· Lukman, S, Grant GH, Bui,
Jennifer M. Unraveling evolutionary
constraints: a heterogeneous conservation in dynamics of the titin Ig domains
. FEBS Lett. 2010 Mar
· Jennifer M. Bui, Joerg A. Gsponer,
Vendruscolo M., Christopher Dobson. “Analysis of sub-c and supra-c
motions in protein Gβ1 using molecular dynamics simulations”, Biophys J. 1998 Aug;75(2):662-71
· Jennifer M. Bui, Cavalli A, Gsponer, J.,
Identification of Aggregation-prone Elements using Interaction Energy Matrices,
Angewandte Chemie Int.,
· Gsponer J., Christodoulou J.,
Cavalli A., Richter B., Jennifer M. Bui,
Dobson C. M and Vendruscolo M., “Correlated dynamics underlie
the efficient ligand binding of calmodulin – a model for swift equilibrium
shifts”, Structure, (2008),
· J. Andrew McCammon and Jennifer M. Bui, Intrinsic Conformational Flexibility of
Acetylcholineterase, J. Chem-Biol. Interact., (2008).
· Jennifer M. Bui and J. Andrew McCammon, Protein
Complex Formation Mechanism: Fast Conformational Transitions of Neurotoxin
Fasciculin-2 in Complex with Acetylcholinesterase. Proc. Natl. Acad. Sci USA,
103 15451-16456, (2006).
· Jennifer M. Bui , Zoran Radic, Palmer Taylor, J.A. McCammon;
Conformational Transitions in Protein-Protein Binding: The Neurotoxin
Fasiculin-2 Binding to Acetylcholinesterase
Biophysical Journal, 90, 3280-3287 (2006)
Senapati, Jennifer M. Bui, and J.A.
McCammon; Induced Fit in Mouse
Acetylcholinesterase upon Binding syn-TZ2PA6: A Molecular Dynamics Study. J. Med.
Chem. Soc., 48,
· David D.L. Minh, Jennifer M. Bui, Chia-en Chang, Tushar
Jain, Jessica M.J. Swanson, and J. Andrew McCammon. Molecules Losing Space: An
External Entropy Calculation of
Protein-Protein Association, Fas2 binding to AChE. Biophysical Journal, 89,
Jennifer M. Bui and J.A. McCammon,Acetylcholinesterase: Pivotal Roles of its
Long Omega Loop (CYS69-CYS96) in Regulating Substrate Binding. J. Chem-Biol.
Interact., Vol:157, 357 (2005)
· Jennifer M. Bui, Kaihsu Tai, J.A. McCammon, Acetylcholinesterase: Enhanced Fluctuations
and Alternative Routes to the Active Site in the Complex with Fasciculin-2. J. Amer. Chem.
Soc., 126, 7198-7205
· Jennifer M. Bui, R.H. Henchman, J.A. McCammon, The Dynamics of the Ligand Barrier
Crossing inside the Acetylcholinesterase Gorge, Biophysical Journal. 85, 2267-2272 (2003).
D. Research Support
K01 ES018854 (Bui)
I am currently implementing new
Rosetta Enzyme Design (RED) Scheme that accounts for protein dynamics and apply
it to engineering human paraoxonase as
bioscavengers to sequester toxic organophosphate compounds.