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OHBM Abstract - and award!

posted Mar 9, 2018, 1:04 AM by Juan Eugenio Iglesias   [ updated Mar 13, 2018, 9:20 AM ]

Our abstract "Rare genetic events in sporadic Alzheimer’s disease: a network propagation approach" (first author, Marzia Scelsi, senior author, Andre Altmann) has been accepted as an oral presentation at OBHM. 

The abstract presents a method to investigate the effects of rare variants in sporadic Alzheimer's disease cohorts, such as the ADNI, and is based on signal diffusion on a gene-interaction network. Using 800 subjects from ADNI, the results show a robust correlation between the volume of hippocampal subfield CA3 and the smoothed mutation profile of two genes (CLU, OTUD4). In addition, the study also found significant enrichment for these genes and their 179 interactors was found for: genes up-regulated in brains of patients with AD and with incipient AD; neuron development; dendrites; and protein phosphorylation. 

Congrats, Marzia, Andre, et al.!

Update: the submission has won a Merit Abstract Award. Big congrats, Marzia!