PubMed Abstracts :

[Full length article available free online: Topics include Dermatitis Herpetiformis, Psoriasis, Alopecia Areata, Chronic Urticaria, Hereditary Angioneurotic Edema, Cutaneous Vasculitis, Atopic Dermatitis, and Other]
Celiac disease and dermatologic manifestations: many skin clue to unfold gluten-sensitive enteropathy
PMID: 22693492  May 2012

Celiac disease (CD) is an autoimmune gluten-dependent enteropathy characterized by atrophy of the intestinal villi that improves after a gluten-free diet. CD is often associated with extraintestinal manifestations. In the past few years, growing evidence has documented the involvement of skin diseases among the extraintestinal manifestations of CD. This association could be related to the impairment of intestinal absorption and motility, other than to immunological and hormonal changes. The aim of this review is to report all CD-associated skin manifestations described in the literature and to analyze the possible mechanisms involved in this association. The opportunity to evaluate the possible presence of CD in patients affected by skin disorders is discussed.
Celiac disease: from gluten to skin.
Expert Rev Clin Immunol
. 2009 Nov;5(6):789-800.
PMID: 20477697  Nov 2009


But the results of treatment with a gluten-free diet are sufficiently rewarding to
justify investigation of any patient in whom malabsorption is even suspected. Accordingly the possibility of an abnormality of the intestine should be kept in mind in all patients with
intractable eczema.

If an abnormality of either structure or function of the gut is discovered a therapeutic
trial with a gluten-free diet is indicated.


PMID: 14260617 April 1965
Full Text:


Antigliadin IgA prominently increases in patients diagnosed with psoriasis. Patients with psoriasis should be investigated for latent CD and should be followed up.
Coeliac disease-associated antibodies in psoriasis
PMID: 24003271  Aug 2013


Psoriasis in a nationwide cohort study of patients with celiac disease.
PMID:21654830  Oct  2011

We found a significantly higher level of AGA in patients with psoriasis than in controls, but levels of tTG and EMA were not significant. There was also a significantly higher prevalence of AGA, tTG and EMA in the patient group (34.1%, 34.1% and 14.6%, respectively) than in the control group (2.4%, 22% and 4.9%, respectively). We conclude that the significantly high prevalence of AGA antibodies in patients with psoriasis supports the possibility of a link between psoriasis and gluten-sensitive enteropathies, especially CD.
Estimation of (IgA) anti-gliadin, anti-endomysium and tissue transglutaminase in the serum of patients with psoriasis.
PMID: 21418272  April 2011

Our study concludes that latent CD or CD-associated antibodies were present in patients with psoriasis and also concludes that HLA Cw6 has no association with expression of these antibodies in patients with psoriasis.
Celiac disease-associated antibodies in patients with psoriasis and correlation with HLA Cw6.
PMID: 20626025  July 2010

Conclusions Patients with psoriasis have a greater prevalence of CD than matched controls. Recent studies showed a possibility of undiagnosed CD among patients with psoriasis. Therefore, physicians treating patients with psoriasis should be aware of this possible association.
Coeliac disease associated with psoriasis.
PMID: 19785615  July 2009

Some patients presenting IgA/IgG antigliadin antibodies and who are gluten-sensitive improve after a gluten-free diet.
[Nutritional influences in psoriasis]
PMID: 19377768  2009 Jan-Feb

Results Patients with psoriasis have significantly higher mean concentrations of antibodies against tissue transglutaminase (human recombinant and guinea pig-derived antigen) and against gliadin for IgA. IgA antibodies against tissue transglutaminase (both antigens) and gliadin positively correlate with psoriasis activity. No anti-endomysial antibodies for IgA were found in any serum. Conclusions Our results seem to imply an association between psoriasis and asymptomatic celiac disease/gluten intolerance. High percentage of positive results to guinea pig-derived tTG could be due to cellular activity of tissue transglutaminase in psoriasis.
Serologic markers of celiac disease in psoriatic patients. 
PMID: 18384553  April 2008

Coeliac disease-associated antibodies correlate with psoriasis activity.
PMID: 15491433 Oct 2004

High prevalence of celiac disease in psoriasis.
PMID: 14638373  Nov  2003

In the entire group of patients, as well as in those on a gluten-free diet as the only treatment, Ki67 + cells in involved dermis were highly significantly decreased after the diet.
Gluten-free diet in psoriasis patients with antibodies to gliadin results in decreased expression of tissue transglutaminase and fewer Ki67+ cells in the dermis.
PMID: 14690336  2003

The present case supports the association between CD and psoriasis and the concept that psoriasis in CD patients can be improved by GFD
Rapid Regression of Psoriasis in a Coeliac Patient after Gluten-Free Diet. A Case Report and Review of the Literature. PMID: 12949434  2003

Patients with PsoA have an increased prevalence of raised serum IgA AGA and of coeliac disease. Patients with raised IgA AGA seem to have more pronounced inflammation than those with a low IgA AGA concentration.
Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet.  Full text 
PMID: 10651693  Jan 2002

Thirty of the 33 patients with AGA completed the GFD period, after which they showed a highly significant decrease in mean PASI. This included a significant decrease in the 16 AGA-positive patients with normal routine histology in duodenal biopsy specimens
Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet.
PMID: 10651693  Jan 2000

It was recently observed that in six patients with psoriasis and one with palmoplantar pustulosis, with newly discovered gluten intolerance, a gluten-free diet had a remarkable effect on the skin lesions.
Patients with psoriasis often have increased serum levels of IgA antibodies to gliadin.
PMID: 8286249  Dec 1993


Does urticaria risk increase in patients with celiac disease? A large population-based cohort study.
PMID:24135663  Oct 2013

The present case of subclinical celiac disease diagnosis in an otherwise asymptomatic child with chronic urticaria further reinforces the evidence that differential for celiac disease warrants to be always considered in children with refractory urticaria.

Chronic urticaria and celiac disease: a case report.

Pediatr Dermatol
. 2010 Jan 1;27(1):108-9.
PMID: 20199432

After 7 months of a gluten-free diet, the boy's anemia resolved and he is free of symptoms when exposed to cold. This is a first description of the possibility of an association between celiac disease and cold urticaria. A poor course of cold urticaria in the absence of evidence of another underlying condition should lead to suspicion of celiac disease.

Cold urticaria and celiac disease.
PMID: 18447142  April 2008

Dermatitis herpetiformis (DH) is a chronic pruritic cutaneous eruption associated with gluten-sensitive enteropathy (celiac disease [CD]) and immunoglobulin A (IgA) deposition in the skin. While the disease is not uncommon among adolescents, DH is rarely seen in prepubertal patients. Children with DH present similarly to adults; however, uncommon skin findings have been reported. Because of an increased risk for autoimmune diseases and lymphoma, accurate diagnosis and treatment are imperative. We present a case of DH in a 6-year-old Latino boy previously diagnosed with atopic dermatitis and recurrent urticaria. Our aim is to highlight the various cutaneous presentations of DH and encourage clinicians to consider this diagnosis in young patients with recalcitrant atypical skin disease.
Childhood dermatitis herpetiformis: a case report and review of the literature.
PMID: 18246879  Dec 2007

We report an 11-year-old boy with an unusual presentation of DH characterized by a 7-month history of chronic urticaria-like skin lesions. He had evanescent, largely asymptomatic, urticarial wheals on his trunk, face, and extremities that were unresponsive to conventional therapy for urticaria. Skin biopsy specimen findings were consistent with DH and direct immunofluorescence of perilesional skin was diagnostic. The patient had no symptoms of gluten-sensitive enteropathy at the time of diagnosis, and his skin lesions rapidly cleared with dapsone therapy. This patient serves to highlight an unusual presentation of childhood DH and the need to consider this diagnosis when evaluating chronic urticarial lesions in children.
Dermatitis herpetiformis presenting as chronic urticaria
PMID: 15461764

Celiac sprue is a chronic malabsorptive disorder that occurs in predisposed individuals secondary to ingestion of gluten. An increase of atopic or immunologic disorders has been reported in the setting of gluten enteropathy. The incidence of urticaria [hives] and celiac sprue is unknown but appears to be rare.
Celiac disease presenting as urticaria.
PMID: 15176493 (rare???)

Chronic urticaria and coeliac disease.
PMID: 14977723

Urticaria and adult celiac disease.
PMID: 10505471

Chronic urticaria atopic dermatitis and celiac disease
PMID: 1442710

Chronic urticaria associated with coeliac disease.

PMID: 2879987

We believe that this is the first report of this association in a child, highlighting that CU may be a part of the spectrum of autoimmune phenomenon related to celiac disease. (non-responsive to gfd)
Celiac disease associated with familial chronic urticaria and thyroid autoimmunity in a child.

PMID: 10429142

Fifty-five patients had a history of recent dyspeptic symptoms. A diagnosis of adult celiac disease was made in two patients and, additionally, IgA antigliadin antibodies were seen in four patients. H. pylori IgG antibodies were found in 40 out of 107 patients.
Etiologic aspects of chronic urticaria.

PMID: 9679692


Repigmentation of vitiligo lesions in a child with celiac disease after a gluten-free diet.
PMID:21504457  Mar 2011

Other skin conditions

Management of palmoplantar pustulosis. Do we need to change?
PMID: 21275942  Jan 2011

A gluten-free diet led to weight gain and resolution of the chilblains.
Celiac disease presenting with chilblains in an adolescent girl.
PMID: 17014640  Sep-Oct 2006

[Linear IgA bullous dermatosis associated with celiac disease.]
PMID: 16885852  June 2006

This report demonstrates that linear IgA bullous dermatosis can respond to gluten restriction if an underlying gluten-sensitive enteropathy is present.
Linear IgA bullous dermatosis responsive to a gluten-free diet. 
PMID: 11419853 June 2001

We present a 16-year-old girl with a 4-year history of chronic persistent erythema nodosum. Recurrently low serum iron values suggested the possibility of a malabsorption syndrome. The presence of antitransglutaminase and antiendomysium antibodies and the jejunal biopsy specimen findings showed an underlying celiac disease. On a strict gluten-free diet, the skin lesions resolved and the girl has since remained symptom free for 9 months.
Erythema nodosum in association with celiac disease.

PMID: 15165200