Gluten Sensitivity vs Celiac Disease
The Gluten File
A Video Presentation by Dr. Peter Osborne
Check out Part 3, between the 4:30 - 8:00 minute marks
A. Vojdani, T. O'Bryan, and G.H. Kellermann
The immunology of gluten sensitivity beyond the intestinal tract
Aristo Vojdani, Ph.D., M.T.1*; Thomas O’Bryan, D.C., C.C.N., D.A.C.B.N.2
"The term "celiac disease" implies a disease characterized by an abnormal small intestinal biopsy with either clinical or histologic improvement following adherence to gluten-free diet.8 These patients may or may not have serologic evidence of the disease.
The term "gluten sensitivity" has been used to describe 2 groups of patients: 1) those with gastrointestinal symptoms responsive to gluten withdrawal9,10 and 2) those with positive antigliadin, antiendomysial, or antitransglutaminase antibodies.11 The presence of HLA DQ2 or DQ8 has been used to suggest that "gluten sensitivity" is related to CD.12 "
The term 'coeliac disease' should now be restricted to describe gluten sensitive enteropathy. The term gluten sensitivity describes a spectrum of disease that have in common an immune response to the ingestion of gluten, but with diverse manifestations such as an enteropathy (coeliac disease), dermatopathy (dermatitis herpetiformis) and neurological disorders (e.g. Gluten ataxia). Not suprisingly, the common aetiological trigger (gluten) means that these diseases overlap considerably. For example, the vast majority of patients with dermatitits herpetiformis also have an enteropathy, as do a third of patients with gluten ataxia (Hadjivassiliou et al. 2003b).
ALSO from same article:
"Neurologic manifestations of gluten sensitivity are a scientific fact, not a theological issue. Whilst the debate continues, we owe it to our patients to screen them effectively for gluten sensitivity with the simple widely available antigliadin antibody test so that we do not in the meantime deprive them of a harmless but potentially effective treatment in the form of a gluten-free diet."
By definition, a diagnosis of Celiac Disease requires biopsy evidence of intestinal villous atrophy.
Might there be other gluten related autoantibodies that attack other organs, even in the absense of Celiac Disease? Research is looking~
A gluten free diet is usually only recommended to those who meet the criteria for a Celiac Disease diagnosis. Unfortunately, that leaves many Gluten Sensitive people suffering unneccesarily with very serious symptoms that might resolve on a gluten free diet... if they only knew... and puts them at risk for further complications.
There are MANY other doctors I could include on this list. As mentioned elsewhere, most DAN! doctors, or doctors practicing orthomolecular or environmental medicine will understand gluten sensitivity can cause serious problems and support a gluten free diet for their gluten sensitive patients.
As of 2008, some of the more prominent celiac research experts, including Dr. Peter Green and Dr. Alessio Fasano are publicly acknowledging gluten sensitivity without celiac disease exists, and that these patients may benefit from a gluten free diet.
I'm personally so grateful that the Internet provided me access to the research of Dr. Kenneth Fine and Dr. Marios Hadjivassiliou back in the year 2000 when my family was suffering from a cryptic gluten sensitivity. Our only clue was an isolated IgG antigliadin antibody in both of my daughters. Despite being told by our local doctors that a gluten free diet was not necessary unless there was biopsy proof of celiac disease, we moved ahead anyway based on the research of these two men. We haven't looked back.
Dr. Marios Hadjivassiliou
Dr. John B Symes, DVM aka "DogtorJ"
Dr. Vikki Petersen