Food Sensitivity & Leaky Gut Syndrome
Many people with Celiac Disease or Non-Celiac Gluten Sensitivity find they have problems with additional food intolerances. In Celiac Disease, this might be temporary and once the intestinal villi have healed, sometimes the secondary problem foods can be successfully added back. In those with multiple food sensitivies, one has to question overall gut health and other factors that may be involved.
The difference between IgE (classic food allergy) and IgG (delayed) food allergy is still somewhat controversial, but...it seems IgG food allergy is gaining recognition as a real player in ill health.
I'm not pretending to have all the answers when it comes to food allergy, but I do know it can be a subject of great interest as we struggle to be well. Hope some of the information I leave here can speed your journey to better health!
Discussing Leaky Gut Syndrome
PubMed on Intestinal Permeability (aka "Leaky Gut")
Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible individuals, autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing the zonulin-dependent intestinal barrier function. Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases.
Leaky gut and autoimmune diseases.
PMID 22109896 Feb 2012
Recent studies investigating the underlying mechanisms involved in disease development in diabetes point to the role of the dys-regulation of the intestinal barrier. Via alterations in the intestinal permeability, intestinal barrier function becomes compromised whereby access of infectious agents and dietary antigens to mucosal immune elements is facilitated, which may eventually lead to immune reactions with damage to pancreatic beta cells and can lead to increased cytokine production with consequent insulin resistance. Understanding the factors regulating the intestinal barrier function will provide important insight into the interactions between luminal antigens and immune response elements. This review analyses recent advances in the mechanistic understanding of the role of the intestinal epithelial barrier function in the development of type 1 and type 2 diabetes. Given our current knowledge, we may assume that reinforcing the intestinal barrier can offer and open new therapeutic horizons in the treatment of type 1 and type 2 diabetes.
Leaky gut and diabetes mellitus: what is the link?
PMID:21382153 June 2011
of the gastric pH increases the risk for sensitization against food
allergens by hindering protein breakdown. This can be caused by
acid-suppressing medication like sucralphate, H2-receptor blockers and
proton pump inhibitors, as shown in recent murine experimental and human
observational studies. CONCLUSIONS: Antacids
and dietary supplements influencing the gastric pH increase the risk for
sensitization against allergenic food proteins. As these substances are
commonly used in the general population without consulting a physician,
our data may have a major practical and clinical impact.
CONCLUSION: This is the first randomised, cross-over study in migraineurs, showing that diet restriction based on IgG antibodies is an effective strategy in reducing the frequency of migraine attacks. [Free full text available on PubMed]
Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, cross-over trial.
PMID: 20647174 July 2010
Milk protein IgG and IgA: the association with milk-induced gastrointestinal symptoms in adults.
More on Food Allergy:
"Oxidative stress plays an important role in inflammatory process of celiac disease.....
Lycopene, quercetin and tyrosol inhibited all these effects. The results here reported suggest that these compounds may represent non toxic agents for the control of pro-inflammatory genes involved in celiac disease."
"Autoimmune states can be induced by food sensitivities that cause intestinal gut permeability and complicate leaky gut syndrome (Kitts et al. 1997)." Oxidative stress and autoimmune problems by LEF LEF
"We've had many patients who were extremely sensitive to dairy and wheat.... and did marvelously after the CF/GF diet. Many of these same patients completely lost their sensitivity to casein and gluten after the antioxidant supplementation..... and now can eat a normal diet without a problem. (Aug 21, 2003) " [NOT Celiac Disease...jcc.. please read in entirety.]