IBS, IBD, Crohn's
[Irritable bowel syndrome, celiac disease and gluten.]
PMID:23983652 Feb 2013
Conclusions: About one third of the IBS patients included in the study
were suffering from FH and were cured on the elimination diet.
A comparison between two different in vitro basophil activation tests for gluten- and cow's milk protein sensitivity in irritable bowel syndrome (IBS)-like patients.
PMID: 23183757 Nov 2012
Screening patients with IBS-D or IBS-mix for CD
is almost certainly cost-effective. The screening program would improve
the quality of life of those patients with IBS symptoms who actually
have CD at a relatively low cost.
Targeted screening for Coeliac Disease among irritable bowel syndrome patients: analysis of cost-effectiveness and value of information.
PMID: 23179163 Nov 2012
Twenty-five percent of patients with IBS have
FH. These patients had increased levels of fecal ECP and tryptase,
indicating that they might cause inflammation in patients with IBS.
Fecal assays for ECP could be used to identify FH in patients with IBS.
Fecal assays detect hypersensitivity to cow's milk protein and gluten in adults with irritable bowel syndrome.
PMID:21839707 Nov 2011
Hypersensitivity to Cow's Milk Protein and Gluten in Adults with Irritable Bowel Syndrome. PMID: 21839707 Aug 2011The present findings support the notion that IBS patients should be routinely examined for CD. This applies to all subtypes of IBS.
The prevalence of celiac disease in patients with irritable bowel syndrome.
PMID:21468583 May 2011
After years of inattention, there is a growing body of evidence to suggest that dietary constituents at least exacerbate symptoms and perhaps contribute to the pathogenesis of the irritable bowel syndrome (IBS). Although patients with IBS self-report food allergies more often than the general population, the evidence suggests that true food allergies are relatively uncommon. Less clearly defined food intolerances may be an important contributor to symptoms in IBS patients. This article reviews the literature supporting a causal link between food and the symptoms of IBS as well as the evidence supporting dietary interventions as a means of managing IBS symptoms.
Food: the forgotten factor in the irritable bowel syndrome.
PMID:21333905 Mar 2011
significantly reduces the frequency and severity of abdominal pain in
children with IBS; this effect is sustained and may be secondary to
improvement of the gut barrier.
A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain.
PMID: 21078735 Nov 2010
disease is a common finding among patients labeled as IBS. Celiac
disease must be considered in differential diagnosis of IBS especially
in the therapy refractory group.
The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome.
PMID: 20816591 Oct 2010
Does evidence exist to include dietary therapy in the treatment of Crohn's disease?
PMID: 20350266 April 2010
CONCLUSIONS: Abnormal immune reactions mediated by IgG antibodies coexisted in patients with IBS. It is of great significance in treating IBS by eliminating the allergic foods according to the serum level of food-specific IgG antibodies.
[The therapeutic effects of eliminating allergic foods according to food-specific IgG antibodies in irritable bowel syndrome]
PMID: 17967233 Aug 2007
Conceptually, the irritable bowel syndrome (IBS) has been considered a brain-gut functional disorder, but this paradigm is under serious challenge. There is increasing evidence that organic disease of the gastrointestinal tract can be identified in subsets of patients who fulfil the Rome criteria for IBS. Evidence for subtle inflammatory bowel disease, serotonin dysregulation, bacterial overgrowth and central dysregulation continue to accumulate. The underlying causes of IBS remain to be adequately identified, but postinfectious IBS is a clear-cut entity. Furthermore, a genetic contribution to IBS also seems likely. Diagnosis continues to be based on the symptom profile and the absence of alarm features
Irritable bowel syndrome. PMID: 17040359 Nov 2006
DIAGNOSIS, DIFFERENTIAL DIAGNOSIS, AND THERAPY: It is essential to exclude alarm symptoms. IBS can be positively diagnosed with a sensitivity and specificity of > 90% by standardized questionnaires. Indications of PI-IBS are the acute onset of symptoms, fever, vomiting, diarrhea and/or positive stool culture. Differential diagnoses include lactose intolerance, small bowel bacterial overgrowth, bile acid malabsorption, celiac disease, giardiasis, chronic inflammatory bowel disease, collagenous colitis, and diverticulitis. Therapeutic options in PI-IBS remain symptomatic. So far, no specific anti-inflammatory treatment modalities are available.
[Functional and inflammatory bowel disorders]
PMID: 16802539 Mar 2006
Food elimination based on serum immunoglobulin G antibodies in irritable bowel syndrome has been found to result in a significant decrease in symptoms, compared with diets in whichdietary restrictions are not guided by those antibodies. ... That kind of local gastrointestinal hypersensitivity seems to be beyond the reach of current diagnostic methods available in clinical practice. ...SUMMARY: Dietary factors may significantly contribute to the pathophysiology of irritable bowel syndrome. Elimination diets based on the detection of local food hypersensitivity may offer a treatment option for irritable bowel syndrome patients in the future
Food allergy and irritable bowel syndrome.
PMID: 16220050 Nov 2005
CONCLUSIONS: Prevalence of celiac disease seems to be high among patients affected by CD, and this finding should be kept in mind at the time of the first diagnosis of CD; a gluten-free diet should be promptly started.
High prevalence of celiac disease among patients affected by Crohn's disease.
PMID: 15973121 July 2005
Symptom overlap and comorbidity between IBS and other gastrointestinal motility disorders (eg, chronic constipation, functional dyspepsia, gastroesophageal reflux disease), with gastrointestinal disorders that are not related to motility (eg, celiac disease, lactose intolerance), and with somatic conditions (eg, fibromyalgia, chronic fatigue syndrome), are frequent. The clinical associations and pathophysiologic links between IBS and these disorders continue to be explored.
Symptom overlap and comorbidity of irritable bowel syndrome with other conditions.
PMID: 16042909 Aug 2005
In the past inflammatory bowel disease (IBD), celiac disease and irritable bowel syndrome (IBS) were regarded as completely separate disorders. Now, with the description of inflammation, albeit low-grade, in IBS, and of symptom overlap between IBS and celiac disease, this contention has come under question
Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases?
PMID: 16045602 2005
Food-induced immune responses cause or influence a number of intestinal diseases. Food antigens may either directly affect the mucosal immune system, or food modulate the intestinal flora, which may alter the immune response. ~ There are diseases where food is the primary factor in the pathogenesis, such as food allergy and gluten-sensitive enteropathy. Both diseases are mediated by different types of immune reactions. ~ Yeast antigens, especially in people with a defect in the innate immune system, such as MBL-deficiency may lead to an enhanced immune reactivity to mannan antigens of yeast. This may have some significance in the perpetuation of intestinal inflammatory processes in patients with Crohn's disease.
Food-Induced Immune Responses as Origin of Bowel Disease? PMID: 16024931 July 2005
...the diarrhea stopped only after maintaining a gluten-free diet. A latent form of celiac disease (clinical symptoms, improvement after gluten-free diet, detection of anti-gliadin IgA antibodies, negative histology) was diagnosed.
Association of Crohn's disease and latent celiac disease: a case report and review of the literature.
PMID: 15578194 July 2005
Anti-Saccharomyces cerevisiae and perinuclear anti-neutrophil cytoplasmic autoantibodies are markers of Crohn's disease and ulcerative colitis respectively. ~CONCLUSION: More than half of untreated coeliacs are anti-S. cerevisiae-positive irrespective of the severity of mucosal damage. Differently from immunoglobulin A, anti-S. cerevisiae-immunoglobulin G persisted in more than 80% after gluten free diet. The high prevalence of anti-S. cerevisiae in coeliac disease suggests that they may be the effect of a non-specific immune response in course of chronic small bowel disease.
Anti-Saccharomyces cerevisiae and perinuclear anti-neutrophil cytoplasmic antibodies in coeliac disease before and after gluten-free diet.
PMID: 15801923 April 2005
Nevertheless, dietary manipulation may result in substantial improvement in IBS symptomatology provided it is individualized to the particular patient. By further understanding the mechanisms involved in dietary intolerance, it should be possible to optimize the benefits of this approach to treatment.
The role of food intolerance in irritable bowel syndrome.
PMID: 15862933 June 2005
The most important differential diagnoses are celiac disease, colorectal carcinoma and colitis.
Diagnostic approach to suspected irritable bowel syndrome.
PMID: 15324711 Aug 2004
In the article insufficiency of existing patterns of investigation of patients with irritated bowel syndrome (IBS) during differential diagnostics with celiac disease is underlined, that leads to wrong diagnostics and inefficient treatment of patients. Also own data on prevalence of celiac disease in patients with IBS are shown. Determination of the level of specific markers of celiac disease (in our research--antigliadin Ig) is considered to be the optimal method of diagnostic celiac disease in this group of patients.
Prevalence of undiagnosed celiac disease in patients with irritated bowel syndrome PMID: 14723137 Nov 2003
BACKGROUND & AIMS: Abdominal symptoms in the absence of mucosal abnormalities are features of both the irritable bowel syndrome (IBS) and latent/potential celiac disease (cd). To identify a possible subgroup of IBS patients with latent/potential cd, surrogate markers of cd were investigated in IBS patients. ~ CONCLUSIONS: HLA-DQ2 expression and increased intestinal cd-associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.
Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome.PMID: 11729112 Dec 2001
RESULTS: The results showed that ASCA positivity occurred not only in Crohn's disease but also in Celiac disease and in these cases both the IgG and IgA type antibodies were proved. CONCLUSION: It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn's disease.
Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease. PMID: 14562398 Oct 2003