A subset of children with autism displays
increased immune reactivity to gluten, the mechanism of which appears to
be distinct from that in celiac disease. The increased anti-gliadin
antibody response and its association with GI symptoms points to a
potential mechanism involving immunologic and/or intestinal permeability
abnormalities in affected children.
Markers of Celiac Disease and Gluten Sensitivity in Children with Autism.
PMID: 23823064 June 2013
RESULTS:: A high percentage of abnormal IPT values were found among
patients with autism (36.7%) and their relatives (21.2%) compared with
normal subjects (4.8%). Patients with autism on a reported
gluten-casein-free diet had significantly lower IPT values compared with
those who were on an unrestricted diet and controls. Gastrointestinal
symptoms were present in 46.7% of children with autism: constipation
(45.5%), diarrhoea (34.1%), and others (alternating
diarrhoea/constipation, abdominal pain, etc: 15.9%). FC was elevated in
24.4% of patients with autism and in 11.6% of their relatives; it was
not, however, correlated with abnormal IPT values. CONCLUSIONS:: The
results obtained support the leaky gut hypothesis and indicate that
measuring IPT could help to identify a subgroup of patients with autism
who could benefit from a gluten-free diet. The IPT alterations found in
first-degree relatives suggest the presence of an intestinal
(tight-junction linked) hereditary factor in the families of subjects
Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives.
PMID: 20683204 July 2010
Possible gastrointestinal symptoms in a subset of children with autism.
PMID: 20350258 April 2010
The ScanBrit randomised, controlled, single-blind
study of a gluten- and casein-free dietary intervention for children
with autism spectrum disorders.
PMID: 20406576 April 2010
Evaluation, diagnosis, and treatment of
gastrointestinal disorders in individuals with ASDs: a consensus report.
Pediatrics. 2010 Jan;125 Suppl
PMID: 20048083 Jan 2010
aspects of autism. Review]
PMID: 19961061 Sept 2009
symptoms are described in 9-54% of autistic children, among which most
common are: constipation, diarrhea and abdominal distension. The
gastro-intestinal abnormalities reported in autism include: inflammation
(esophagitis, gastritis, duodenitis, enterocolitis) with or without
autoimmunity, lymphoid nodular hyperplasia, increased intestinal
permeability, low activities of disaccharidase enzymes, impairment of
detoxification (e.g. defective sulfation of ingested phenolic amines),
dysbiosis with bacterial overgrowth, food intolerance or exorphin
intoxication (by opioid derived from casein and gluten). A beneficial
effect of dietary intervention on behavior and cognition of some
autistic children indicates a functional relationship between the
alimentary tract and the central nervous system.
abnormalities in children with autism]
19650428 July 2009
Related to PMID 19650428:
"However this is
of particular interest given the recent publication by Eaton and
colleagues in the July 6 online edition of Pediatrics demonstrating a
greater than 3-fold risk of autism in children born to mothers diagnosed
with celiac disease. This brings some credibility to the anecdotal
reports of gastrointestinal and behavioral improvements in children with
autism spectrum disorders and/or verbal apraxia when eliminating gluten
from their diets."
Hospital Oakland scientist characterizes new syndrome of allergy,
regarding family history of type 1 diabetes and infantile autism and
maternal history of rheumatoid arthritis and ASDs were confirmed from
previous studies. A significant association between maternal history of
celiac disease and ASDs was observed for the first time. The observed
associations between familial autoimmunity and ASDs/infantile autism are
probably attributable to a combination of a common genetic background
and a possible prenatal antibody exposure or alteration in fetal
environment during pregnancy.
A case is
presented of a 5-year-old boy diagnosed with severe autism at a
specialty clinic for autistic spectrum disorders. After initial
investigation suggested underlying celiac disease and varied nutrient
deficiencies, a gluten-free diet was instituted along with dietary and
supplemental measures to secure nutritional sufficiency. The patient's
gastrointestinal symptoms rapidly resolved, and signs and symptoms
suggestive of autism progressively abated. This case is an example of a
common malabsorption syndrome associated with central nervous system
dysfunction and suggests that in some contexts, nutritional deficiency
may be a determinant of developmental delay. It is recommended that all
children with neurodevelopmental problems be assessed for nutritional
deficiency and malabsorption syndromes.
Celiac Disease Presenting as Autism.
PMID: 19564647 June 2009
Growing evidence suggests that
autoantibodies to neuronal or endothelial targets in psychiatric
disorders exist and may be pathogenic. This review describes and
discusses the possible role of autoantibodies related to the psychiatric
manifestations in autoimmune diseases, autoantibodies related to the
psychiatric disorders present in post-streptococcal diseases, celiac
disease, chronic fatigue syndrome and substance abuse, and
autoantibodies related to schizophrenia and autism, disorders now
considered of autoimmune origin.
Autoantibodies associated with
PMID: 16719797 May 2006
Improvement of neurobehavioral
disorders in children supplemented with magnesium-vitamin B6. II.
Pervasive developmental disorder-autism .TACA has a much more complete compilation of
PMID: 16846101 Mar 2006