Autism

The Gluten File

Dietary intervention has proven effective for many children with Autism, in both gastrointestinal and behavioral symptoms. Although not all children will show improvement, the reports of thousands of children who have improved remarkably can no longer be ignored by mainstream medicine.

There may be two different problems at work when it comes to autism and gluten or casein: the autoimmune problem and the gluten/casein peptide problem.  There does seem to be some increase or overlap in those families with history of celiac disease or other autoimmune disease. 


Dietary Support Sites:

Specific Carbohydrate Diet

The GFCF Diet Support Group Information Website


Vitamin D and Autism
Vitamin D and Autism by the Vitamin D Council
More on Autism by Vitamin D Council
http://www.vitamindcouncil.org/newsletter/another-autism-case-report.shtml
http://www.vitamindcouncil.org/newsletter/more-letters-on-autism.shtml
http://www.vitamindcouncil.org/newsletter/update-on-autism-and-vitamin-d.shtml

 

Internet Resources:

ARI - Binding of Infectious Agents, Toxic Chemicals, Dietary Peptides...

Autism One 

Autism One Radio

Autism: An Overview: Gluten/Casein Theories and Relation to Celiac Disease

Autism Spectrum and Dietary Intervention

The Autism Research Institute - Founded by Dr. Bernard Rimland

Center for the Study of Autism

Citations on Celiac Disease and Autism.

DAN! (Defeat Autism Now!) DAN! Doctors are typically classically trained medical doctors, who further specialize in DAN! protocol, and apply their training to treat autism biomedically. 

Generation Rescue - A very well maintained, easy to reference complete website for all things autistic with biomedical and other treatment options.
(Jenny McCarthy)

Genova Diagnostics 

Great Plains Laboratory

JAMA and Archives: Autism Collection

Dr. Jacquelyn McCandless' Website - Children with Starving Brains

Dr. Woody McGinnis on Autism

National Autism Association

Regressive autism may be linked to autoimmune enteropathy

Talk About Curing Autism

The Texas based Thoughtful House Center for Children

Vitamin D and Autism by the Vitamin D Council

A pathogen-autoimmune hypothesis for autism.  



Book Recommendation:

Healing the New Childhood Epidemic
AUTISM, ADHD, ASTHMA, and ALLERGIES
by Kenneth Bock, MD, and Cameron Stauth
 

Check out the reviews at Amazon.com



PubMed Abstracts:


Immune system of a subgroup of ASDs is triggered by gluten and casein; this could be related either to AGA, DPG, and Casein IgG elevated production or to impaired intestinal barrier function.
Antibodies against food antigens in patients with autistic spectrum disorders.

PMID:23984403  Aug 2013


CONCLUSIONS AND RELEVANCE Although this study found no association between CD or inflammation and earlier ASDs, there was a markedly increased risk of ASDs in individuals with normal mucosa but a positive CD serologic test result.
A Nationwide Study of the Association Between Celiac Disease and the Risk of Autistic Spectrum Disorders.
PMID: 24068245  Sept 2013

A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in celiac disease. The increased anti-gliadin antibody response and its association with GI symptoms points to a potential mechanism involving immunologic and/or intestinal permeability abnormalities in affected children.
Markers of Celiac Disease and Gluten Sensitivity in Children with Autism.
PMID: 23823064  June 2013
 

RESULTS:: A high percentage of abnormal IPT values were found among patients with autism (36.7%) and their relatives (21.2%) compared with normal subjects (4.8%). Patients with autism on a reported gluten-casein-free diet had significantly lower IPT values compared with those who were on an unrestricted diet and controls. Gastrointestinal symptoms were present in 46.7% of children with autism: constipation (45.5%), diarrhoea (34.1%), and others (alternating diarrhoea/constipation, abdominal pain, etc: 15.9%). FC was elevated in 24.4% of patients with autism and in 11.6% of their relatives; it was not, however, correlated with abnormal IPT values. CONCLUSIONS:: The results obtained support the leaky gut hypothesis and indicate that measuring IPT could help to identify a subgroup of patients with autism who could benefit from a gluten-free diet. The IPT alterations found in first-degree relatives suggest the presence of an intestinal (tight-junction linked) hereditary factor in the families of subjects with autism.
Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives.
PMID: 20683204  July 2010

Possible gastrointestinal symptoms in a subset of children with autism.
PMID: 20350258 April 2010
Free Article:
http://www.expert-reviews.com/doi/pdf/10.1586/egh.10.17

The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders.
Nutr Neurosci
. 2010 Apr;13(2):87-100.
PMID: 20406576 April 2010

Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report.
Pediatrics
. 2010 Jan;125 Suppl 1:S1-18.
PMID: 20048083
  Jan 2010

[Immunogenetic aspects of autism. Review]
PMID: 19961061  Sept 2009

Gastrointestinal symptoms are described in 9-54% of autistic children, among which most common are: constipation, diarrhea and abdominal distension. The gastro-intestinal abnormalities reported in autism include: inflammation (esophagitis, gastritis, duodenitis, enterocolitis) with or without autoimmunity, lymphoid nodular hyperplasia, increased intestinal permeability, low activities of disaccharidase enzymes, impairment of detoxification (e.g. defective sulfation of ingested phenolic amines), dysbiosis with bacterial overgrowth, food intolerance or exorphin intoxication (by opioid derived from casein and gluten). A beneficial effect of dietary intervention on behavior and cognition of some autistic children indicates a functional relationship between the alimentary tract and the central nervous system.
[Gastrointestinal abnormalities in children with autism]
PMID: 19650428  July 2009

Related to PMID 19650428:
"However this is of particular interest given the recent publication by Eaton and colleagues in the July 6 online edition of Pediatrics demonstrating a greater than 3-fold risk of autism in children born to mothers diagnosed with celiac disease. This brings some credibility to the anecdotal reports of gastrointestinal and behavioral improvements in children with autism spectrum disorders and/or verbal apraxia when eliminating gluten from their diets."
Children's Hospital Oakland scientist characterizes new syndrome of allergy, apraxia, malabsorption 

Conclusions: Associations regarding family history of type 1 diabetes and infantile autism and maternal history of rheumatoid arthritis and ASDs were confirmed from previous studies. A significant association between maternal history of celiac disease and ASDs was observed for the first time. The observed associations between familial autoimmunity and ASDs/infantile autism are probably attributable to a combination of a common genetic background and a possible prenatal antibody exposure or alteration in fetal environment during pregnancy.

A case is presented of a 5-year-old boy diagnosed with severe autism at a specialty clinic for autistic spectrum disorders. After initial investigation suggested underlying celiac disease and varied nutrient deficiencies, a gluten-free diet was instituted along with dietary and supplemental measures to secure nutritional sufficiency. The patient's gastrointestinal symptoms rapidly resolved, and signs and symptoms suggestive of autism progressively abated. This case is an example of a common malabsorption syndrome associated with central nervous system dysfunction and suggests that in some contexts, nutritional deficiency may be a determinant of developmental delay. It is recommended that all children with neurodevelopmental problems be assessed for nutritional deficiency and malabsorption syndromes.
Celiac Disease Presenting as Autism.
PMID: 19564647  June 2009

Growing evidence suggests that autoantibodies to neuronal or endothelial targets in psychiatric disorders exist and may be pathogenic. This review describes and discusses the possible role of autoantibodies related to the psychiatric manifestations in autoimmune diseases, autoantibodies related to the psychiatric disorders present in post-streptococcal diseases, celiac disease, chronic fatigue syndrome and substance abuse, and autoantibodies related to schizophrenia and autism, disorders now considered of autoimmune origin.
Autoantibodies associated with psychiatric disorders.
PMID: 16719797 May 2006

Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II. Pervasive developmental disorder-autism .
PMID: 16846101 Mar 2006

We conclude that a subgroup of patients with autism produce antibodies against Purkinje cells and gliadin peptides, which may be responsible for some of the neurological symptoms in autism.
Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism.
PMID: 15526989  June 2004

TACA has a much more complete compilation of research:
http://gfcf-diet.tacanow.org/dietary-research-in-asd.htm