So we are told isolated anti-gliadin antibodies are non-specific, and therefore regarded as meaningless by most doctors, particularly AGA IgG antibodies. That leaves us (at least me) wondering what other conditions are associated with antigliadin antibodies. I went looking~ and found the following.
Curious minds want to know~
Do antigliadin antibodies suggest gluten sensitivity may be involved in diseases other than Celiac Disease? If gluten can cause Celiac Disease, why is it such a far stretch to consider it might be directly relevant in other autoimmune disease? If gluten sensitivity can cause autoimmune disease, what about a similar response to other foods? Casein? Soy?
Association does not prove cause, granted. BUT, it is interesting to me that so many of these other conditions have not only increased associations with Celiac Disease, but anecdotal reports (and a few medical journal reports, to boot) of some of these patients with other autoimmune conditions improving on a gluten free diet. When other conditions improve or resolve on a gluten free diet, what does that say???
I sure don't have all the answers, but I provide this page in response to the doctor's who say antigliadin IgG or IgA antibodies are non-specific, but leave us wondering what "other" conditions they are seen in. Can't wait to see where the research has taken us in another ten years!
Testing for gluten-related disorders in clinical practice: The role of serology in managing the spectrum of gluten sensitivity.
PMID:21523259 April 2011
Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age.
From: The Neurology of Gluten Sensitivity: Science
is also confusion about the role of antigliadin antibodies as a
screening tool. Given that gluten sensitivity can exist without
enteropathy, it is inappropriate to estimate sensitivity and specificity
of these antibodies against the presence of enteropathy as the 'gold
standard'. To assert that antigliadin antibodies lack specificity based
on the fact that 10% of the healthy population may have them is a
misconception. It is entirely plausible that 10% of the healthy
population with circulating antigliadin antibodies have gluten
sensitivity without recognized manifestations. The prevalence of coeliac
disease itself is now recognized to be 20 times higher than what it was
thought to be 20 years ago because most cases are clinically silent. It
is important to realize that amongst the 10% antigliadin antibody
positive people lurks those with 'silent' gluten sensitive enteropathy."
ill-considered to suggest that antigliadin antibodies should not be used
as a screening tool because they are found in “healthy” individuals. It
is also irresponsible to suggest that neurological patients should not
be screened for coeliac disease unless additional factors are present
such as unexplained anaemia or evidence of malabsorption."
"Neurologic manifestations of gluten sensitivity are a scientific fact, not a theological issue. Whilst the debate continues, we owe it to our patients to screen them effectively for gluten sensitivity with the simple widely available antigliadin antibody test so that we do not in the meantime deprive them of a harmless but potentially effective treatment in the form of a gluten-free diet."