The Kim Lab

Welcome to the Kim Laboratory at the University of Texas at Dallas. Our research group is focused on understanding the role of hypoxic response in the regulation of tumor microenvironmental remodeling and metabolic reprograming in cancers. Another major focus of our research is to understand the role of stromal fibroblasts in cancer progression and fibrosis.

Selected Publications

1. Yun Sok Lee*Jung-whan Kim*, Olivia Osborne, Da Young Oh, Simon Schenk, Ai Chen, Anne Murphy, Oswald Quehenberger, Brian Scott, Wolfgang Dillman, Randall Johnson**, and Jerrold Olefsky**. Increased adipocyte O2 consumption triggers HIF-1a causing inflammation and insulin resistance in obesity. Cell, 157:1339-52 * equally contributed first authors, ** equally contributed corresponding authors

2. Andrew Cowburn, Norihiko Takeda, Adam Boutin, Jung-whan Kim, Jane Sterling, Manando Nakasaki, Colin Jamora, Victor Nizet, Edwin Chilvers and Randall Johnson. HIF Isoforms in the Skin Differentially Regulate Systemic Arterial Pressure. PNAS, 110:17570-5 (2013)

3. Jonathan Chou, Jeffrey Lin, Audrey Brenot, Jung-whan Kim, Sylvain Provot and Zena Werb. GATA3 Suppresses Metastasis and Modulates the Tumor Microenvironment by Regulating miR-29b Expression. Nature Cell Biology, 15:201-213(2013)

4. Jung-whan Kim, Colin Evans, Alexander Weidemann, Norihiko Takeda, Yun Sok Lee, Christian Stockmann, Cristina Branco-Price, Filip Branberg, Gustavo Leone, Michael Ostrowski and Randall Johnson. Loss of Fibroblast HIF-1a Accelerates Tumorigenesis. Cancer Research, 72:3187-95 (2012)

5. Norihiko Takeda, Ellen L. O’Dea, Andrew Doedens, Jung-whan Kim, Alexander Weidemann, Christian Stockmann, Masataka Asagiri, M. Selete Simon, Alexander Hoffmann and Randall S. Johnson. Differential activation and antagonistic function of HIF-a isoforms in macrophages are essential for NO homeostasis. Genes and Development 24:491-501 (2010)

6. Jung-whan Kim, Ping Gao, Yen-Chun Liu, Gregg L. Semenza and Chi V. Dang. HIF-1 and dysregulated c-Myc cooperatively induce VEGF and metabolic switches, HK2 and PDK1. Mol. Cell. Biol. 27:7381-7393 (2007)

7. Ryo Fukuda, Huafeng Zhang, Jung-whan Kim, Larissa Shimoda, Chi V. Dang, and Gregg L. Semenza. HIF-1 regulates cytochrome oxidase subunit composition to optimize the efficiency of respiration of hypoxic cells. Cell 129:111-122 (2007)

8. Jung-whan Kim, Irina Tchernyshyov, Gregg L. Semenza, and Chi V. Dang. HIF-1-mediated expression of PDK: a metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3:177-185 (2006) *Featured Cover Article (Mar 2006)

9. Jung-whan Kim, Karen I. Zeller, Yunyue Wang, Anil G. Jegga, Bruce J. Aronow, Kathryn A. O’Donnell, and Chi V. Dang. Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays. Mol. Cell. Biol. 24:5923-5936 (2004)