website by Jamie Baird-Titus
in the College of Medicine
In the Rance Lab, we use NMR and molecular dynamics simulations to further our understanding of the dynamic/motional processes governing molecular function and intermolecular interactions. Recently, we have solved the structure of the bicoid homeodomain by NMR and used intermolecular NOEs to the consensus duplex DNA site to solve the structure of the protein/DNA complex using the program AMBER. (PDB entry - 1ZQ3)(NDB entry)(JMB Paper) (Faculty-of-1000) (OCA Atlas Entry)(BMRB Entry 6906) We have also recently solved the structure of the PITX-2 homeodomain in the same manner (work of Beth Chaney), (PDB entry- 1YZ8)(NDB entry)(Biochemistry Paper)(OCA Atlas Entry), and examined the effects of calcium binding on the the side-chain methyl dynamics of calbindin D9k using deuterium relaxation (work of Eric Johnson), (JMB Paper).
Here are the members of the Rance Lab (Mark is in the center of the picture) as of September 2005. That's me on the far left. Since this picture was taken, Eric Johnson (second from left) has graduated and moved on to a post-doc in the laboratory of Rafael Bruschweiler at the National High Magnetic Field Laboratory. Kimber Clark-Baldwin (second from right) has left the world of science to start her own knitting business, and Beth Miller (on far right) has obtained a position as a medical science writer at Kendle. Since September, we have a new post-doc, Doug Kojetin, from the lab of John Cavanaugh, a new technician, Al Combs, who joins us from the lab of Joanna Groden, and a new student, Thomas Doerdelmann.
Last modified 3/27/2007.