Welcome to the Issadore Lab

Our lab combines microelectronics, microfluidics, and nanomaterials to create miniaturized platforms for the diagnosis of disease. This work requires an interdisciplinary approach in which engineers, scientists, and physicians work together to solve high impact problems in healthcare. 

We are currently looking to bring in both new post-docs and graduate students, please contact me directly [Issadore (at) seas.upenn.edu] if you are interested in joining the lab.




12/1/2017 Our tutorial on Machine Learning for Liquid Biopsy just came out in Lab on a Chip.

12/1/2017 Jina's CTC FISH paper is highlighted on the Lab on a Chip Blog!

11/11/2017 Enormously proud of our team: 

11/1/2017 Jina wins Lab on a Chip's Widmer prize for best poster at µTAS. Way to go Jina!

10/12/2017 Two new awesome papers out! Jess's on-chip diafiltration system in LOC and Jina's exosome based pancreatic cancer diagnostic in ACS Nano.

9/21/2017 Vasant Iyer has joined our group as our very first ESE PhD student! He'll be co-advise by Firooz Aflatouni in ESE.

9/8/2017 We were just officially told what everyone already knew, Jina's CTC FISH paper is HOT! We were listed by the editors at LOC in their collection of 'Hot' articles. An awesome honor for an awesome paper.

8/17/2017 Behold the future of the pharmaceutical industry:

8/9/2017 Jina's CaTCh FISH Chip is published! We dedicate this work to Reviewer 2, whoever you are.

8/1/2017 Zijian Yang joins the group, the lab's very first Mechanical Engineering student!

7/26/2017 Ravi wins first poster prize at this year's Microfluidic Congress!!

7/12/2017 Dave and Jina headed out to Utah to give a talk at the annual Neurotrauma Conference to report on our traumatic brain injury diagnostic. It was a fun conference, in particular the enthusiastic game of 3-way Spit played at 1 AM in the Salt Lake City airport with Alex from the Meaney Lab.

7/6/2017 Heon Ho's super duper fast bubble blower was just published in Lab on a Chip!

6/1/2017 The Issadore Lab is representing at The Gordon Conference on Microfluidics in Tuscany, Italy.

5/31/2017 Follow the exploits of David's class Appropriate Point of Care Diagnostics in Kumasi, Ghana.

5/1/2017 We are very proud to be part of the Allen Foundation's $9.8M grant to study TBI at Penn. Also, I'm very excited that we were featured in the Inquirer.  It's thrilling to be mentioned on the same pages as my hero Inga Saffron and my anti-hero Stu Bykofsky.

4/13/2017 I'm very happy to announce that Ravi has won "Judge's Favorite Prize" at this year's Penn iTalks!

YouTube Video

3/21/2017 Jina and David are attending a great conference on exosomes in the central nervous system at The New York Academy of Sciences. There is a very long line to speak with Jina at her poster:

3/1/2017 We are happy to report that Chip Diagnostics, a company spun out of our lab, has received a second round of funding from the IP Group.

2/14/2017 Happy Valentine's Day! Ravi's paper on building a mobile, super super super fast droplet based platform just came out in LOC. Check it out!


12/10/2016 Aloha! Dave travels to the big island of Hawaii for the IEEE Micro and Nanotechnology in Medicine Conference.

10/8/2016 The Issadore Lab (minus only a few) fly to BMES in Minneapolis to present.

8/8/2016 Jina's beautiful cell phone based traumatic brain injury diagnostic was just published in Scientific Reports!

7/9/2016 My TedX talk got put online. Slightly embarrassing, but here it is... (youtube)

7/15/2016 Sagar gave a fantastic talk on his ultra-high throughput droplet generator at this year's ACS Colloid meeting up at Harvard. 

7/3/2016 We are super excited to welcome our newest post-doctoral fellow, Zhiping Zhang.

5/27/2016 Absolutely awesome lab BBQ:



5/5/16 Two super exciting papers just came out! Jina and Ravi published their gorgeous electroformed magnetic micropore chip in Lab on a Chip, demonstrating 100x improved flow rate over previous devices! And, Mike from the Chow lab published his undergraduate-friendly synthetic biology system in ACS Synthetic Biology.

4/3/16 Lab selfie. (need to invest in lab selfie stick)

4/1/16 We're incredibly grateful to The Hartwell Foundation for funding our work on developing diagnostics for pediatric brain cancers.

2/23/16 Chip Diagnostics, a startup company spun off from our lab, is born! Thank you IP Group for your generous funding.

2/20/16 Not only are we being allowed to enter the Union League, we're being honored there! Dave is receiving the Young Engineer of the Year Award from IEEE's Philadelphia chapter.

2/9/16 Dave is super psyched to be receiving a CAREER award from the NSF's CBET.

1/20/16  Ravi wins this year's Microsoft Graduate Student Fellowship! Go Ravi!


12/21/2015 We are very grateful to be receiving support for our work on early detection of pancreatic cancer from the American Cancer Society.

11/14/2015 Jina, Ravi, and Dave take a journey down to the NIH for the annual IMAT PI meeting. The NIH is such a great place, except for the coffee and food. Life without food trucks is hardly life at all. 

10/27/15 Jina and Ravi win (first place) at this year's Singh Center Poster Contest! Nishal took third. And, even second was taken by an Issadore lab alumni. I'm kvelling.

10/13/15 Celebrating three newly minted PhD candidates (1 in absentia):

9/29/15 Our paper just came out in Lab on a ChipBillions (with a B!) of identical droplets per minute!

9/16/15 Interested in starting a business based on our wacky research? Here's one way to do it: The Y Prize

9/13/15 Jina's paper, the definitive review on using microchips to isolate and detect exosomes, just came out in Analyst.

9/2/15 Ravi and Jess passed their qualifying exams! Congratulations PhD candidate Yelleswarapu and PhD candidate Liu!

7/2/15 Jess receives the Neuroengineering and Medicine training fellowship from the Center for Neuroengineering and Therapeutics. Go Jess!

6/27/15 Sydney's article on diagnosing viral infections using Turbo FISH on a Chip just came out in Lab on a Chip.

5/27/15 An extremely successful lab BBQ:


5/27/15  David will be heading to sunny San Diego for the Point-of-Care Diagnostics & Global Health World Congress. Be there or be square.

4/15/15 Nishal Shah has (re)joined our lab as a BE PhD student!

3/21/15 Ravi won first prize in this year's Biomedical Graduate Group's Poster Session. Go Ravi!

3/18/15 David will be traveling to DC to give a talk on detecting rare cells for disease diagnostics at this year's Next Generation Dx Summit in DC. Be there or be square.

3/10/15 Jina is traveling to beautiful New Orleans to give a talk on her CTC isolation work at this year's Pitt Con.

2/24/15 Dave will be a keynote speaker at this year's Northeast Bioengineering Conference. Be there or be square.

2/1/15 We are grateful for (more) seed funding from University of Pennsylvania's Nano Bio Interface Center.

2/18/15 Senior design student, Ashwin Amurthur wins the Y prize for his proposal to use graphene nanosensors to detect benzene leaks from fracking sites. 

2/15/15 Nishal and Dave's super awkward photo is now the background on the main Upenn.edu webpage. Not exactly sure why.

2/1/15 Mobile Health Technologies was published with a chapter from us.


12/15/14 We are very excited to have a new post-doc joining our group, Dr. Sagar Yadavali from University of Tennessee .

11/20/14 Our multiplexed droplet detector is featured in the 2014 collection of "Hot Articles" by Lab on a Chip

10/3/14 Melaku's paper on miniaturizing the readout of multiplexed droplet based assays just came out in Lab on a Chip.

10/1/14 Melaku's paper on integrating millimeter-scale integrated circuits (ICs) with microfluidics just came out in Lab on a Chip.

9/1/14 We are grateful to the National Cancer Institute's Innovative Molecular Analysis Technologies (IMAT) program for funding our exosome research.

8/20/14 After 1 year and 10 months of an extremely productive post-doc, Melaku is moving out to sunny California to join a promising point of care diagnostics startup company (Wave80 Biosciences).

7/21/14 Benita's paper on controlling conventional microlfuidics with paper microchannels was highlighted in Lab on a Chip.

7/11/14 Melaku's Track Etched Magnetic MicroPOre (TEMPO) work is featured on this month's cover of Advanced Healthcare Materials.

5/23/14 Max Wasserman receives a Littlejohn award to work in our lab this summer.

5/2/14 David won this year's S. Reid Warren Jr. Award for undergraduate education. 

4/1/14 Nishant, Max, Jaime, and Lauren's senior design project is featured in the Daily Pennsylvanian.

3/27/14 Noor, Arielle, Peter, and and Anthony's senior design project is featured in the Daily Pennsylvanian.

2/17/14 Our nanoparticle synthesis work is featured in the SPIE Newsroom.

2/17/14 Melaku and Wu's paper on track-etched magnetic sorting has been published in Advanced Healthcare Materials.

2/11/14 We are grateful to be receiving a grant from Pennsylvania Department of Health's Commonwealth Universal Research Enhancement Program (CURE).

1/27/14 Melaku will be receiving a Berkman Opportunity Fellowship for our work on cancer diagnostics with the Raj and Stanger lab. Thank you David Berkman for your generous support.

1/22/14 Lab Youtube videos!

1/11/14 David spends a few days down in Bethesda at the NIH, learning about new programs on the diagnosis of cancer in developing countries.


12/4/13 Masters student Benita Chumo's work on combining paper and open channel microfluidics onto a single chip has been published in Biomicrofluidics.

10/7/13 Our first two papers are out! The first is Melaku's beautiful work on integrating many droplet makers onto a single chip in Lab on a Chip. The second, a review article in Advanced Drug Delivery Reviews.

9/24/13 David spends the week in rainy Seattle, giving a talk on bacteria detection at the annual BMES conference.

9/12/13 David now has a secondary appointment in ESE. ESE students interested in our research, please contact me directly.

7/29/13 We are grateful to be receiving this year's pilot award from Penn's Center For AIDS Research (CFAR) and from Penn's Nano Bio Interface Center (NBIC).

7/12/13 We did not let a little rain stop an awesome lab BBQ.


5/25/13 Masters student Benita Chumo graduates!

5/13/13 Our paper on microwave synthesis of nanoparticles on a chip, done in collaboration with Dorota Koziej from ETH Zurich and the Weitz group at Harvard, just came out in Nanoscale.

4/21/2013 Rising Sophomore Kinjal Shah wins this year's Advancing Women in Engineering award!

3/18/2013 The Issadore lab spends the week at Pitt Con, which strangely enough is in Philadelphia not in Pittsburgh.

1/30/13 Our book, Point of Care Diagnostics on a Chip is now available.


12/6/12 David travels to Beijing, China to participate with the U.S. National Institute of Allergy and Infectious Disease in this year's China-US Symposium on Nanobiology and Nanomedicine. 

11/14/12 David gives a talk on detecting circulating tumor cells at the National Cancer Institute's Center for Cancer Nanotechnology Excellence's principal investigator's meeting

11/5/12 David gives a talk at the Nano/Bio Interface Center on hybrid electronic / microfluidic chips 

10/25/12 David gives a talk on circulating tumor detection in Atlanta for the annual BMES conference

10/15/12 Post-doctoral researcher Melaku Muluneh has joined the group!

10/1/12 Masters student Benita Chumo joins the group!