Course with Hein Putter & Theodor A. Balan (3 Nov 2017)

The Czech National Group of the 
International Society for Clinical Biostatistics

in cooperation with

Institute of Computer Science, Czech Academy of Sciences in Prague &

Faculty of Mathematics and Physics, Charles University in Prague       

kindly invites you to attend a 1-Day Course on

"Frailty Models: Theory & Practice"


presented by

Hein Putter & Theodor Adrian Balan

Leiden University Medical Center, The Netherlands

Where:                                 Institute of Computer Science of the Czech Academy of Sciences 
                                             (in Czech: Ústav informatiky AV ČR, v.v.i.)
                                             Room # 318 
                                             Pod Vodárenskou věží 2
                                             Prague 8 - Ládví (Metro red line "C", exit "Ládví")
                                             Czech Republic

When:                                  3 Nov 2017 (Friday)
Registration deadline:       16 Oct 2017 (payment has to be received by this date)

Registration:                       Registration consists of two steps: 
(i) Informing the Course Secretary (CS) about your intent to pay the registration fee and asking her for an approval to register for the course 

NotePlease, note that the course capacity is limited to a maximum of 30 participants (see the CS' contact details below). Should the course reach its capacity, a notification will be placed here.

(ii) Posting appropriate payment to the bank account shown below (bank transfer only)         

Registration rates:


Early Bird

(until 31 Aug 2017)


(1 Sep – 16 Oct 2017)

ISCB student member*

1 500 CZK

60 EUR

2 000 CZK

80 EUR

ISCB regular member*

2 000 CZK

80 EUR

2 500 CZK

100 EUR

Non-ISCB member – academia /

non-commercial institutions

4 000 CZK

160 EUR

5 250 CZK

210 EUR

Non-ISCB member – business /

commercial institutions

10 000 CZK

400 EUR

13 250 CZK

530 EUR

        *) Both 2017 and 2016 ISCB membership required

Payments only via bank transfer (*** all international payments need to be made in EUR ***)

All domestic (CZK) and international transfers (EUR), including Slovakia:

Account number:                 2100009829 / 2010

Bank account owner:          Mezinárodní společnost pro klinickou biostatistiku v České

                                            republice, z.s.

IBAN:                                   CZ3820100000002100009829

BIC code/SWIFT:                 FIOBCZPPXXX

Bank name and address:     Fio banka, a.s., V Celnici 1028/10, Praha 1, Czech Republic


Course Venue:
Institute of Computer Science AS CR
Pod Vodarenskou vezi 2
182 07 Prague
Czech Republic
Course Secretary:

Ms. Lenka Semeráková

Dept. of Medical Informatics & Biostatistics

Institute of Computer Science AS CR

Tel. +420 266 053 640

Course Outline

Frailties are random effects in models for time-to-event data. They represent unobserved heterogeneity and can be used for two purposes: modelling dependence in clustered failures or recurrent events (shared frailties), and explaining lack of fit of univariate survival models, such as deviation from the proportional hazards assumption (individual frailties). Shared frailty models are increasingly used in applied research; a Google Scholar search of “shared frailty” yields 4490 results for 2016, compared to 3100 for 2011 and 1930 in 2006. Individual frailties on the other hand have recently been used to explain selection effects in epidemiological studies and to shed light on a number of paradoxes in epidemiology, like the obesity paradox.


The aim of this course is 1) to explain the selection effects of unobserved heterogeneity (individual frailty) in epidemiological studies and to illustrate how many strange artefacts can be explained from a frailty point of view, and 2) to show how to use shared frailty models in practice. With respect to the latter, we will review classical results and discuss practical aspects, such as software to fit frailty models, properties of different frailty distributions, and possible ways of extending such models.

Course' Content


Tentative Course Schedule

8:00 - 9:00  Registration

9:00-12:00  Morning session (includes 20 min coffee break)

12:00-13:00  Lunch break

13:00-16:00  Afternoon session (includes 20 min coffee break)

16:10-16:30  Closing discussion and course evaluation