 Czech National Group of the International Society for Clinical Biostatistics in cooperation with the Institute of Computer Science AS CR in Prague, and, Faculty of Mathematics & Physics of the Charles University in Prague    are delighted to invite you to attend
a 1-day course on „Design and Analysis of N of 1 Trials“
presented by
Honorary Professor in Design, Trials & Statistics The University of Sheffield, United Kingdom WHERE (Ústav informatiky AV ČR) Room # 318 Pod Vodárenskou věží 2 Prague 8 - Ládví (Metro red line "C", exit "Ládví") Czech Republic WHEN 8 November 2019 (Friday) REGISTRATION DEADLINE 21 October 2019 (Monday) COURSE ABSTRACTN of 1 trials are trials in which individual patients are repeatedly treated with experimental and control treatments in a deliberate and designed manner using principles of control, randomisation and replication. Their uses include personalising treatment and increasing efficiency by reducing the number of patients it is necessary to study. In chronic diseases, sets of n-of-1 trials (in which a limited number of patients follow an n-of-1 protocol) have great potential as phase IV trials for understanding components of variation but may also constitute possible Phase III programmes for rare diseases. They can also be used as phase II studies for proof of concept and dose-finding. However, they are often poorly analysed and, indeed, much of the published advice is poor. This course will present the latest thinking on n-of-1 trials and cover not only their analysis through SAS®, R® GenStat® and meta-analysis packages but also approaches to design. They will also be critically examined as to their potential use in a) establishing average effects of treatment b) studying the extent to which such effects vary from patient to patient and c) optimising treatment for individual patients. REFERENCES2. Araujo A, Julious S, Senn S. Understanding Variation in Sets of N-of-1 Trials. PLoS One 2016; 11: e0167167. 3. Makubate B, Senn S. Planning and analysis of cross-over trials in infertility. Stat Med 2010; 29: 3203-3210. 4. Senn SJ. Sample size considerations for n-of-1 trials. Statistical Methods in Medical Research 2019; 28: 372-383.
COURSE SCHEDULE 8:00-9:00 Registration 9:00-12:00 Morning session (part 1-2, includes 15 min coffee break) 12:00-13:00 Lunch break 13:00-16:00 Afternoon session (part 3-4, includes 15 min coffee break) 16:10-16:30 Course conclusion
(*) Note: ISCB membership is required for 2018 and 2019 Payments by bank transfer ONLY (* All international payments have to be made in EUR *) ACCOUNT INFORMATION For all domestic (CZK) and international transfers (EUR): Bank's name and address: Fio banka, a.s., V Celnici 1028/10, Praha 1, Czech Republic Account owner Mezinárodní společnost pro klinickou biostatistiku v České republice, z.s. Account number 2100009829 / 2010 IBAN CZ3820100000002100009829 BIC code/SWIFT FIOBCZPPXXX Important!!: Before you make a payment, please, e-mail an inquiry to the Course Secretary Ms. Lenka Semeráková for confirmation. The number of course participants is limited to 30. Should the course reach its capacity, a notification will be placed here. For institutions making payments on behalf of their employees: The payment identification number (variabilní symbol) is 20191108. Please, remember to state the name of an employee on whose behalf the payment is made in the comment for the payment recipient (poznámka pro příjemce).
COURSE VENUE Czech Academy of Sciences Pod Vodarenskou vezi 2 182 07 Prague Czech Republic COURSE SECRETARY Dept. of Medical Informatics & Biostatistics Institute of Computer Science Czech Academy of Sciences Tel. +420 266 053 640 E-mail: semerakova@cs.cas.cz | |||||||||||||||||||||||||
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