and rheumatic disease
Descriptions of fever in the context of rheumatic
diseases date back to Hippocrates , with early
descriptions of rheumatic fever.
The prevalence of fever in different inflammatory diseases (e.g.
Adult-onset Still’s disease, systemic lupus erythematosus, Systemic vasculitis)
is likely to be dictated by the production of specific pyrogens (e.g. IL-1, IL-6 and immune complexes).
- Low grade fever
is common in chronic inflammatory diseases
process is driven by inflammatory mediators that also serve to function as
commonly used to treat immune-mediated inflammatory disease, such as NSAIDs and Glucocorticoids may
mask the febrile component of rheumatic disease.
drugs may also
- An acute
polyarthritis presenting with fever may well be associated with an acute
viral infection (e.g. parvovirus).
- A rule of thumb
remains that fever must prompt systematic and robust investigation to