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Acromegaly is a rare syndrome that results when the anterior pituitary gland produces excess growth hormone (GH) after epiphyseal plate closure at puberty 

Arthorpathy is seen in up to 74% of affected patients. The knees, shoulders, hips, lumbosacral spine, and cervical spine are the most freqeuntly symptomatic areas, but the hands reveal the most characteristic radiographic changes (e.g. soft tissue thinkening, deformation of epiphyses with squaring of enlarged terminal phalanx/Phalages, chondrocalcinosi, ireased joint/disc space etc.)