IPPA 2018 Conference‎ > ‎PANEL SESSIONS‎ > ‎Panel S10‎ > ‎

S10-14

Denisovan introgression to Philippine Negritos

Naruya SAITOU
National Institute of Genetics, Mishima, Japan


Human presence in Southeast Asia dates back to at least 40,000 years ago,when current islands formed single continental shelf called Sundaland. In Philippine Islands, Peninsular Malaysia, and Andaman Islands, there exist indigenous groups called Negritos. We compared their genome-wide single nucleotide polymorphism data with those of other populations. Phylogenetic tree analyses showed that Negritos are basal to other East and Southeast Asians. We also found relatively high traces of Denisovan admixture in the Philippine Negritos, but not in the Malaysian nor Andamanese groups, suggesting independent introgression and/or parallel losses involving Denisovan introgressed regions. These results show the unique status of Negrito groups and we proposed to rename Negritos as “First Sundaland People” in Jinam, et al. (2017; Genome Biology and Evolution, 9(8):2013–2022). We generated whole genome sequences of 10 least admixed Aeta (Negrito people in Central Luzon Island). PSMC analysis showed that Aeta and Papuan started to diverge ca. 50,000 years ago. TreeMix tree also showed their basal status among human populations currently distributed in South East Asia.


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