-Dr. Sebastiano Venturi.
Investigator on Iodine Deficiency Disorders
and Iodine Metabolism
Già Medico del Servizio di Igiene, Regione Marche

Member of the Italian Thyroid Association (AIT)

Editor of "Reports in Thyroid Research"




                         Curriculum Vitae
Dr. Sebastiano Venturi, member of Italian Thyroid Association, studied goiter and cretinism and the action of iodine in stomach, breast, brain, skin, saliva and immunity. He participated in 2007-Beijing Summit and in 2013-London Congress, where he reported "Iodine, PUFAs and Iodolipids" in J. of "HUMAN EVOLUTION". In 1985, 1999 and 2000 he published the first studies of extrathyroid antioxidant action of iodine. In 1993, 2000-3 he reported the first reviews in medical literature on the association between iodine and stomach and breast cancers. From 2000 to 2014 he published researches on iodine in the evolution, where iodide constitutes the first inorganic antioxidant in a living system. In 2000, 2007, Venturi published the first studies on the evolution of many dietary antioxidants in marine and terrestrial animals.
 
   of Iodine





 
-Gastric cancer
-Atrophic gastritis
-Breast cancer
-Goitre
-Salivary Glands
-Oral Health
-Immunity
-Atherosclerosis
-Iodine metabolism
-Iodide as an antioxidant
-Iodine-prophylaxis
-Cretinism
-Neuropsycological Pathologies
-Human Brain
-Mammalian hypothyroidism as  a          phylogenetical regression  

-Evolution:
-Evolution of Terrestrial
  Antioxidants
-Evolution of Dietary  Antioxidants

-Vitamin C in Evolution
-Selenium: Evolution in Biology
-Apoptosis
-Iodolipids
-Human Evolution
-Terrestrial Life

Dr. Sebastiano Venturi
via Tre Genghe n. 42;  47864
PENNABILLI (RN) ;  (Italy)

Tel : (+39) 0541 928205.

E-mail :
dr.venturi.sebastiano@gmail.com

C.V.

Updated:  Feb. 4 , 2019


                                                  THE IODINE STORY-2016. by Edition by New materials Laboratory, Japan

                                                         http://media.wix.com/ugd/9b993e_ed0f48788fe144f3a0b0e04541f17084.pdf


                                          Iodine's story in human evolution - 2016   by Gene Rosov:     https://www.youtube.com/watch?v=pdHyJLtICY8  


SELECTED PUBLICATIONS

 
 

Cell Biochemistry & Physiology
1969
Sebastiano Venturi
Figure A: entire cell          Figure B: superior part of the cell          Figure C: inferior part of the cell

Studio delle tireopatie nell'Alta Valmarecchia e loro profilassi
Booklet, Ed. Botticelli, Novafeltria
1978
Sebastiano Venturi
LINK


Preliminari ad uno studio sui rapporti tra cancro gastrico e carenza alimentare iodica: Prospettive specifiche di prevenzione
(Preliminary study on the relation between alimentary iodine deficiency and gastric cancer: specific prevention prospects)  - Book
1985
Sebastiano Venturi

LINK
LINK

Syndrome thyro-gastric. Study on the relation between
alimentary iodine deficiency and gastric cancer

Venturi S, Marani L, Magni MA
In: Ghironzi G, Jackson CE, Schuman BM, Editors. Epidemiology Prevention and Early Detection of Gastric Cancer. Editor CIC Intern. Rome, . (Chapter of book)
1987

[Audiological and neuropsychological development study in a sample of school children from a low-iodine area of the Central Apennines that is endemic for cretinism]
1989
[Article in Italian]
Donati L, Venturi S, Andreani M, Antonelli A, Gori E, Bertoni F, Pruneti CA, Berrettini S, Bruschini P, Baschieri L.
LINK

Role of iodine in delayed immune response.

1985
Marani L, Venturi S, Masala R.
LINK


[Iodine and delayed immunity]
1986
[Article in Italian]
Marani L, Venturi S.
LINK

 An iodine-deficient area with endemic cretinism in the Central Appennines:
studies of neuropsychological
 
development in schoolchildren. 

Donati L, Venturi S, Andreani M, et al.
Journal of Endocrinological Investigation,
1988, 4 :11-12.

Cancro dello stomaco e carenza di iodio nella dieta.
1989
Responsible Nutrition Report, Vol. 4 . Oct. 1989
Venturi S

La carenza di iodio nel Montefeltro: Ricerche ed ipotesi di patologie correlate
1990
Bollettino Epidemiologico Marche. Marzo 1990, anno 3, n. 3 : pp. 29-47 (Chapter of book)
Venturi S

Lo iodio: quale ruolo gioca nella fisiopatologia e nella cancerogenesi dello stomaco? 

Venturi S, Degli Albizi S, Pillitu A, Marani L, Venturi M, Guidi A.

"GASTROENTEROLOGIA OGGI", 3, Ottobre, 1990, Pagg.19-26

Iodio e Cancro Gastrico

"Argomenti di GASTROENTEROLOGIA  CLINICA",  3, 3, pagg.127-130, 1990

Venturi S, Venturi M.

Persistenza di aree di gozzo-cretinismo endemico in Italia: il caso del Montefeltro.
1991
Giornale di Clinica Medica, Vol. LXXII, Nov. 1991, pp. 463-472
Donati L., Antonelli A., Andreani M., Venturi S., Pruneti C.A., Berrettini S., Baschieri L.
LINK

 Clinical picture of endemic cretinism in central Apennines (Montefeltro).
1992
Donati L, Antonelli A, Bertoni F, Moscogiuri D, Andreani M, Venturi S, Filippi T, Gasperini L, Neri S, Baschieri L.
LINK
LINK

TIROIDE:  Vecchi problemi, Nuove prospettive. 
Atti del convegno nazionale di URBINO, 24 Ottobre 1992
Venturi S, Venturi M.
Patologie extra-tiroidee da carenza iodica
 
 
Cretins
 
Goitrous cretins in valleys of Apennines in the Emilia-Romagna and Tuscany regions
between prof. A. Pinchera of Pisa University and prof. J.T. Dunn of Virginia University.
(Photographs by Venturi, 1994)

CRETINISM
Pictures of Arterial and Osteo-Articular Systems of central Italian region cretins
 

A new hypothesis: iodine and gastric cancer
1993
S. Venturi, A. Venturi, D. Cimini, C. Arduini, M. Venturi, A. Guidi
LINK


Dietary Iodine and Gastric cancer
1994-96
S. Venturi - Coll.: M. Venturi, A. Guidi, F.M. Donati
LINK

Humoral thyroid autoimmunity is not involved in the pathogenesis of myxedematous endemic cretinism.
1995
Chiovato L, Vitti P, Bendinelli G, Santini F, Fiore E, Tonacchera M, Mammoli C, Capaccioli A, Venturi S, Pretell E, Pinchera A.
LINK

I disordini extra-tiroidei da carenza iodica. Qual e' il reale fabbisogno di iodio
1996
(Extrathyroid Iodine Deficiency Disorders. What is the real iodine requirement?)
Venturi S, Guidi A, Venturi S
LINK

“The enigma of the function of thyroxine in animal extrathyroidal organs and in primitive stomach"
The Thyroid Gland, Clinical and Experimental. 1998; 1, 23
1998
Sebastiano Venturi


Ruolo dello ioduro nella cancerogenesi dello stomaco e della mammella: un antico antiossidante ?
1998
Sebastiano Venturi
, Mattia Venturi e Marta Venturi
LINK


Does iodide in the gastric mucosa have an ancient antioxidant role ?
IDD Newsletter, 14, 4, Nov. 1998
Sebastiano Venturi and Marta Venturi
LINK

Does dietary iodine prevent gastric cancer ?
1998
Venturi S, Stanghellini V, Donati FM, De Giorgio R, Barbara G, Salvioli B, Corinaldesi R.
LINK

Lo ioduro: un antico antiossidante1999
Sebastiano Venturi and Marta Venturi
LINK

Iodide, thyroid and stomach carcinogenesis:
evolutionary story of a primitive antioxidant?
1999
Sebastiano Venturi and Marta Venturi

http://www.eje-online.org/content/140/4/371.full.pdf

LINK



Absorption, metabolism, accumulation, and volatilization of iodine in algae of the genus Laminaria

http://journal.frontiersin.org/article/10.3389/fpls.2016.01146/full






















Primitivo meccanismo di azione antiossidante nelle alghe (Venturi, 1985; Kuepper el al., 2008; Medrano et al., 2016).


---------------------------------------------

Meccanismo evolutivo della azione antiossidante dello ioduro nelle cellule animali ed umane 

( Venturi S., 1999) .

https://drive.google.com/open?id=1lXHv6090KsoBDA6r1B_OHCLUBjPJm0Bz




    2 I-   --->  I2 + 2 e- (electrons) =  - 0.54 Volt ;


Table 1.     2 I - + Peroxidase + H2O2 + 2 Tyrosine . 2 Iodo-Tyrosine + H2O + 2 e- (antioxidants); 

 2 e- + H2O2 + 2 H+ (of intracellular water-solution) . 2 H2

 Antioxidant biochemical mechanism of iodides (From Venturi, 1985)


Table. 2.     2 I- + Peroxidase + H2O2 + Tyrosine, Histidine, Lipids, Carbons  ---> Iodo-Compounds + H2O + 2 e- (antioxidants) 

Iodo-Compounds: Iodo-Tyrosine, Iodo-Histidine, Iodo-Lipids, Iodo-Carbons 


Antioxidant biochemical mechanism of iodides, the most ancient mechanisms of defense from poisonous reactive oxygen species (Venturi, 1999). 

---------------------------------------------

IODIO: un elemento in cerca di identità

G.I.M.T.  Giornale Ital. Malattie del Torace. Pag.188-9

Cocchi M, Venturi S.

Role of iodine in evolution and carcinogenesis of
thyroid, breast and stomach
2000
S.Venturi, F.M. Donati, M.Venturi, A.Venturi, *L.Grossi and **A. Guidi
LINK
 

 
Scintigrafie

Sequence of 123-iodide total-body scintiscans of a woman after intravenous injection of 123-iodide (half-life: 13 hours); (from left) respectively at 30 minutes, and at 6, 20 and 48 hours. High and rapid concentration of radio-iodide (in white) in extra-thyroidal organs is evident in gastric mucosa of the stomach, epidermis, salivary glands, periencephalic liquor, choroid plexus, ovary, skin and oral mucosa. In gastric mucosa 131-iodide (half-life: 8 days) persists in scintiscans for more than 72 hours. In the thyroid, iodide-concentration is more progressive, as in a reservoir [from 1% (after 30 minutes) to 5.8 % (after 48 hours) of the total injected dose]. High iodide-concentration by the mammary gland is evident only in pregnancy and lactation. High excretion of radio-iodide is observed in the urine.


Environmental iodine deficiency:
a challenge to the evolution of terrestrial life ?
Sebastiano Venturi, Francesco M. Donati, Alessandro Venturi and Mattia Venturi
2000


  

Selenium and iodide: ancient antioxidants of cellular membrane lipids?
2000
Massimo Cocchi and Sebastiano Venturi.
LINK
 
 
Iodide, antioxidant function and omega-6 and omega-3 fatty acids.
Progress in Nutrition. 2000;2, 1:15-19
 Cocchi M and Venturi S.
https://8b4489dc-a-62cb3a1a-s-sites.googlegroups.com/site/iodinestudies/home/Progress%20in%20Nutrition
 
Is there a role for iodine in breast diseases?
2001
Sebastiano Venturi
LINK
  
Iodine deficiency causes precancerous breast dysplasia in rats. (Eskin B., N.Y.Aca. Sci.,  1970)
http://onlinelibrary.wiley.com/doi/10.1111/j.2164-0947.1970.tb02988.x/abstract

Dietary iodine replacement  reverses this mammary dysplasia.  (Eskin B., N.Y.Aca. Sci.,  1970)

 
 
Iodine, helicobacter pylori, stomach cancer and evolution
2003
Venturi S
, Grossi L*, Marra GA*, Venturi A, Venturi M
 
 
Iodio ed Evoluzione   ( Iodine and Evolution )
2004
Sebastiano Venturi § , Loris Grossi*, Gian Angelo Marra ** , Mattia Venturi e Alessandro Venturi
LINK
 
Iodine in Evolution of Salivary Glands and in Oral Health
2005
Sebastiano Venturi , Mattia Venturi
LINK
 

Fig.10 . Scintigrafie sequenziali di donna (già tiroidectomizzata) a distanza di 1 ora e di 6 e 24 ore dalla iniezione endovenosa di iodio-123. E' visibile la elevata iodio-captazione delle ghiandole salivari, a destra dopo 1 e 24 ore, e della mucosa orale e dello stomaco (Venturi, 2009).  

Sequence of 123-I total-body scintiscans of a thyroidectomized 19 woman (for thyroid cancer) after intravenous injection of 123-I; (from left) respectively at 1, 6 and 
24 hours. The highest and rapid concentration of radio-iodide in oral mucosa and salivary glands and in gastric mucosa of the stomach and urinary I-excretion is evident. 
Upper right: I-concentration in salivary glands and oral mucosa after 1 hour. Bottom right: I-concentration in salivary glands and oral mucosa after 24 hours. (Venturi, 2000).  



Iodio ed evoluzione
2006
Venturi Sebastiano
, Venturi Mattia
LINK
 
Evolution of Dietary Antioxidants: Role of Iodine
2007
Venturi Sebastiano
, Venturi Mattia


 
Image result for iodine atherosclerosis aorta venturi

Autoradiography (Pellerin, 1961) : Iodide as antioxidant and anti-atherosclerotic in aorta walls  and skin of rat 



Evolution of Dietary Antioxidant Defences
2007
Venturi Sebastiano
, Venturi Mattia

European Epi-Marker, 2007 Vol.11, 3 :1-12
https://drive.google.com/open?id=1lXHv6090KsoBDA6r1B_OHCLUBjPJm0Bz








 
Iodine, Stomach Cancer and Evolution
Beijng, Oct, 18-20, 2007
Venturi S
, Venturi M.
LINK (5MB)


 
Vitamin C in Evolution
2007
Venturi S

LINK
 
Selenium: Evolution in Biology
2008
Venturi S.

LINK
 
Seminary: "Rola jodu pozatarczycowego w organizmie czlowieka"
POLISH ACADEMY of SCIENCES, PAN: Seminary in Nuclear Medicine and Biology, Krakow, Poland
February 29, 2008
Venturi S. and Venturi M.

LINK

Iodine, Thymus and Immunity
2009
Venturi S. and Venturi M.
Nutrition, 2009; 25 (9) : 977-9
LINK

Iodine in Evolution of Salivary Glands and in Oral Health
2009
Venturi S. and Venturi M.
Nutrition and Health. 2009; 20 (2) :119-134. PMID: 19835108

LINK

"Rola jodu pozatarczycowego w organizmie czlowieka"
POLISH ACADEMY of SCIENCES:
Seminary in Nuclear Medicine and Biology, Krakow, Poland
(Evolution of Dietary Antioxidant Defences)
May 15, 2010
Venturi S. and Venturi M.

LINK

Thyroid Hormone, Iodine and Human Brain Evolution
2010
Venturi S.
and Bégin M. E.
Chapter of book: "Environmental Influences on Human Brain Evolution"
by: Cunnane S. and Stewart K. Publisher: John Wiley, 2010. ISBN: 9780470452684
LINK
 
Evolution of Dietary Antioxidants
March 10-11, 2011, Hong Kong
5th International Functional Food Symposium
Venturi Sebastiano, Venturi Mattia
published in "PROGRESS IN NUTRITION", 2011, 13, 3 :226-227
 and
   EVOLUTION of TERRESTRIAL ANTIOXIDANTS
Venturi Sebastiano, Venturi Mattia
 
Evolutionary significance of iodine
Sebastiano Venturi
Chapter of book published in Current Chemical Biology: Volume 5, 3 Issues, 2011
LINK
LINK
 
 
Iodine and T4 stimulate the spectacular apoptosis (programmed cell death) of the cells of the larval gills, tail and fins Transforming the aquatic, vegetarian tadpole into the terrestrial, carnivorous frog with better neurological, visuospatial, olfactory and cognitive abilities for hunting.  Contrary to amphibian metamorphosis, thyroidectomy and hypothyroidism in mammals may be considered a sort of phylogenetic and metabolic regression  to a former stage of reptilian life. Indeed, many disorders that seem to afflict hypothyroid humans have reptilian-like features, such as dry, hairless, scaly, cold skin and a general slowdown of metabolism, digestion, heart rate and nervous reflexes, with lethargic cerebration, hyperuricemia and hypothermia ( Venturi, 2000).

 
Sebastiano Venturi: quaranta anni di ricerche dei disturbi da carenza di iodio
e  delle patologie tiroidee ed extratiroidee correlate
( Sebastiano Venturi:   forty  years  of  research  on  Iodine  Deficiency  Disorders  and  thyroidal  and  extrathyro​idal  pathologie​s )
Sebastiano Venturi

20 Agosto, 2012
LINK

 

La carenza di iodio nella provincia di Arezzo e in Toscana:

ricerche di patologie tiroidee ed extratiroidee associate
Da "Il CESALPINO": Rivista dell'Ordine dei Medici di Arezzo. n. 32. Dicembre 2012 

LINK

 
Sebastiano Venturi: quaranta anni di caccia ai segreti dello iodio.
Da "Il Notiziario": Rivista dell'Ordine dei Medici di Rimini. Dicembre 2012

LINK

 

Malattie da carenza iodica (Iodine Deficiency Disorders)

Corso di aggiornamento per  MMG della AUSL di Rimini. (intero con audio)
Rimini, 16 Feb. 2013 

LINK


La carenza iodica in Romagna (Iodine Deficiency in Romagna-Italy ) (breve con audio)

con casi locali di CRETINISMO.

https://www.youtube.com/watch?v=yL9fGDqun28

Rimini, 16 Feb. 2013 


Iodine, Iodolipids, Antioxidants, Cancer & Evolution 
2013
Sebastiano Venturi

LINK

 

Iodine, PUFAs and Iodolipids in Health and Diseases: an evolutionary perspective

Human Evolution: Past, Present & Future: Anthropological, Medical & Nutritional Considerations. Congress in London, 8-10th May 2013

2013

Poster
Sebastiano Venturi

 

 

Iodine, PUFAs and Iodolipids in Health and Diseases: an evolutionary perspective.

  Human Evolution: Past, Present & Future: Anthropological, Medical & Nutritional Considerations. 

Congress in London, 8-10th May 2013

S Venturi, CA Castellano, SC Cunnane

2013

Poster


Organic Iodine:

NEW FRONTIERS OF

APPLICATION IN MEDICINE (book), 2014.  (Venturi S. Co-author)


http://iodine.eecsa.kz/wp-content/uploads/2014/10/Iodine_eng_A5+cover2.pdf




Iodine, PUFAs and Iodolipids in Health and Diseases: An Evolutionary Perspective

Congress in London, 8-10th May 2013


In: "HUMAN EVOLUTION" vol. 29  (1-3), pagg. 185-205; 2014, Part 2

S. Venturi, M. Venturi, 2014

Living organisms were confined to the sea-water for more than 3 billion years.When about 500 million years ago plants and ...


Iodine Deficiency in the Population of Montefeltro, A Territory in Central Italy 
Inside the Regions of Emilia-Romagna, Tuscany and Marche with cases of CRETINISM.




In: "INTERNATIONAL  J. of ANTHROPOLOGY" ,  29- n 1-2 (1-12) - 2014
Sebastiano Venturi, 2014
===== LINK =====
 
------o0o-------
Articles in Wikipedia

 IODINE in BIOLOGY  (Audio)


Atherosclerosis: Autoradiography: Iodide as antioxidant and anti-atherosclerotic in aorta walls of rat  ---^

Wikipedia

Antioxidants
Wikipedia

Iodine
Wikipedia

Immunity
Wikipedia

wikipedia





Iodio


 
Evolutions
 

IODINE in EVOLUTION. (2002)
Over three billion years ago, blue-green algae were the first living Prokaryota to produce oxygen in the atmosphere. About 700 million years ago (m/y/a) thyroxine (T4) is present in fibrous exoskeletal scleroproteins of the lowest invertebrates (sponges and corals) without showing any hormonal action. About 500-400 m/y/a some primitive marine fishes started to emerge from the iodine-rich sea (60 ug/L) and transferred to iodine-deficient fresh water (5-0.2 ug/L) and about 400-300 m/y/a these vertebrates evolved in amphibians and reptiles and transferred to I-deficient land. Therefore these vertebrates needed a new follicular organ: the thyroid gland, as reservoir of iodine. These vertebrates started to use its primitive T4 as transporter, into the peripherical cells, of antioxidant iodide and T3. The remaining T3 became the active hormone in the metamorphosis and thermogenesis for a better adaptation to terrestrial environment: fresh water, atmosphere, gravity, temperature and diet.





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