The Journal of Chest Disease and Tuberculosis

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The Journal of Chest Disease and Tuberculosis, ISJN: 5743-8477, Impact Index: 6.13, Imprint: Photon, Category: Peer Reviewed Indexed International Journal


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Diabetic Tuberculosis Cases Characteristics in Baghdad


Abdul razaq M.Y.a, Al Salihi L.G.a, Al-farttoosi A.J.b* 


a Specialized national center for chest and respiratory disease. Baghdad 

b College of Medicine, University of Baghdad. MOHE, Baghdad, Iraq 



Keywords: 

Diabetes, Tuberculosis, characteristics Abbreviations: TB:Tuberculosis DM: Diabetes Mellitus 



Abstract 

Background: There is growing evidence that diabetes is an important risk factor for tuberculosis and might affect disease presentation. This study aimed at findings factors associated with diabetes among Tuberculosis (TB) patients. Objectives: Iraq is one of the countries suffering from prevalence of both TB and Diabetes.Theaim of this study is to identify the characteristics of TB patients with diabetes mellitus in Baghdad. Methods: A case-control study conducted during the period 1/8/2010-31/7/2011. Diabetic tuberculosis patients enrolled as cases and non-diabetic patients as control. Results: 77 diabetic tuberculosis cases and 141 non-diabetic patients. Diabetic tuberculosis patients were older (mean 50.2 ys) than non-diabetic patients (mean 42.2 ys) with lower education level. All of: Age 45-64, low education levels, extra-pulmonarysite of TB and associated medical disease (particularly hypertension) are significantly associated with diabetes in TB patients. Conclusions: Diabetes in Iraqi TB patients is associated with age older than 45, extra-pulmonary site of TB disease and more likely to have associated medial disease (mostly hypertension). As there is no similar studies in Iraq, we hope that our study will take part in improvement of management of tuberculosis in diabetic patients. 





Prevalence, pattern and treatment outcome of TB–HIV co-infection among patients that attended a Referral Hospital in Bayelsa State, South-South Nigeria, West Africa   


Jumbo J.a*, Ikuabe P.O.a, Fetepigi E.A.b  


a Department of Medicine, Faculty of Clinical Sciences Niger Delta University, Wilberforce            Island, Bayelsa State, Nigeria, West Africa 

b Diette Koki Memorial Hospital, Opolo Yenagoa, Bayelsa State, Nigeria 


Jumbo J., Ikuabe P.O. and Fetepigi E.A. are conferred with Robert Koch Research Award-2015 in Medicine 


Keywords: Tuberculosis, human immunodeficiency virus, TB/HIV coinfections, DOTS, Bayelsa State 


Abbreviations: TB: Tuberculosis, HIV: human immunodeficiency virus, AIDS: Acquired Immune Deficiency Syndrome, DOTS: directly observed treatment short-course, AFB: acid-fast bacilli, WHO: World Health Organization 


Photon Ignitor: ISJN57438477D736118052015 


Citation: Jumbo J., Ikuabe P.O., Fetepigi E.A., 2015. Prevalence, pattern and treatment outcome of TB–HIV co-infection among patients that attended a Referral Hospital in Bayelsa State, South-South Nigeria, West Africa. The Journal of Chest Disease and Tuberculosis. Photon 108, 149-154. 


Abstract 

Background: The HIV pandemic presents a massive challenge to the control of TB at all levels. People living with HIV have increased susceptibility to active tuberculosis. Aim: This study is therefore designed to determine the prevalence and treatment outcome of TB and HIV co-infections in a TB referral hospital in Bayelsa state, South-South Nigeria. Methodology: This study is a retrospective survey of records of all Pulmonary Tuberculosis patients who attended a Tuberculosis Referral Hospital DOTS Centre, Igbogene over a 10-year period (January 2003 and December 2012). Results: Out of a total of 3915 patients, HIV-TB co-infection rate was 10%. Majority of the TB patients, 1000 (39.3%) were in the age group 25-34 years out of whom 131(13.1%) were co-infected with HIV accounting for 50%. The TB and HIV co-infection rate was higher in females than in males,156 constituting 9.7% of female patients were co-infected compared to 106 making up 4.7% of male patients (P<0.000). The treatment success rate was higher (67.6%) among HIV negative patients against 57.3% of HIVpositive patients (P<0.001). Conclusion: TB and HIV co-infections are common in Bayelsa State, South-South Nigeria and the HIV positive TB patients had worse treatment outcome.



Modular Teaching as a method of Training Medical Officers on RNTCP in Cuddalore District 


K. Devi*, S. Karunakaran  


Department of Community Medicine, Indira Gandhi Medical College and Research Institute, Pondicherry, India    

K. Devi and S. Karunakaran receive Helen Adams Keller Research Award- 2015 in Tuberculosis


Keywords: Modular teaching, RNTCP (Revised National Tuberculosis Control Programme), training, medical officers, evaluation, pretest, post test


Photon Ignitor: ISJN57438477D764912032015


Citation: Devi K., Karunakaran S., 2015. Modular Teaching as a method of Training Medical Officers on RNTCP in Cuddalore District. The Journal of Chest Disease and Tuberculosis. Photon 108, 145-148.


Abstract 

Research question: Whether modular teaching method can serve as an effective method to train medical officers in Revised National tuberculosis Control Programme (RNTCP). Methods: Cross sectional study was undertaken among 30 medical officers in Cuddalore district. Modular teaching was used to train medical officers to teach “RNTCP” by experts trained in RNTCP. To evaluate their individual performances both pretest and post test was conducted and in addition feedback was also elicited. Results: The overall performance was encouraging as there was significant difference between the pretest and post test scores and percentages (p<0.005). Conclusion: Modular teaching was successfully used to train medical officers in Revised National Tuberculosis Control Programme (RNTCP) in Cuddalore district.


Laryngeal and Oropharyngeal Tuberculosis– A Case Report 

Appiah Thompson Petera*, Anthony Richardb, Edzie Kobina Mesic

a Ear, Nose and Throat Unit, Cape Coast Teaching Hospital & School of Medical Sciences, University of Cape      Coast, Ghana, West Africa  

b Department of Medicine, Effia Nkwanta Regional Hospital, Sekondi & School of Medical Sciences, University     of Cape Coast, Ghana, West Africa 

c Department of Radiology, Cape Coast Teaching Hospital & School of Medical Sciences, University of Cape        Coast, Ghana, West Africa 

Appiah Thompson Peter, Anthony Richard and Edzie Kobina Mesi receive Antonie van Leeuwenhoek Research Award-2015 in Tuberculosis 

Keywords: Tuberculosis, laryngeal, oropharyngeal, dysphagia, odynophagia, caseating, granulomatous 

Photon Ignitor: ISJN57438477D741612032015 

Citation: Peter A.T., Richard A., Mesi E.K., 2015. Laryngeal and Oropharyngeal Tuberculosis– A Case Report. The Journal of Chest Disease and Tuberculosis. Photon 108, 141-144.

Abstract 

Laryngeal tuberculosis is rare even though tuberculosis in general especially the pulmonary type is common in the tropics. The laryngeal disease tends to present with vague and nonspecific symptoms like hoarseness of voice or dysphagia which can pass for a laryngeal malignancy. Laryngoscopic features also simulate a malignancy. Thus confirmation of diagnosis of laryngeal tuberculosis can only be by biopsy of the primary tumour itself. The histopathology would report caseating granulomatous inflammation. Antitubercular treatment gives excellent results when the diagnosis is made. The object of this article is thus to highlight the need for taking biopsies in suspected cases of laryngeal tuberculosis for the appropriate antituberculous medications to be started early. We report on an 18 year old woman who presented to our facility with hoarseness of voice, dysphagia and cough with blood-stained sputum. At direct laryngoscopy she was found to have soft, friable, tiny lesions on both true vocal cords with tonsillar hypertrophy. She was diagnosed of having laryngeal tuberculosis on histopathology. She had a good response to antituberculosis therapy and is now asymptomatic after three years and continuing her education in a tertiary institution.  




Lipids: Key molecules governing pathogenesis in Mycobacterium tuberculosis




Saif Hameed and Zeeshan Fatima*  


Amity Institute of Biotechnology, Amity University Haryana, Gurgaon (Manesar)-122413, India    


Saif Hameed and Zeeshan Fatima receive Robert Koch Research Award-2015 in Tuberculosis


Keywords: Tuberculosis, MDR-TB, Mycobacterium tuberculosis, Lipids, Pathogenicity


Photon Ignitor: ISJN57438477D746526022015


Citation: Fatima Z*., Hameed S., 2015. Lipids: Key molecules governing pathogenesis in Mycobacterium tuberculosis. The Journal of Chest Disease and Tuberculosis. Photon 108, 134-140.


Abstract 

Tuberculosis (TB) is among the leading causes of mortality throughout the world. Mycobacterium tuberculosis (MTB) is the causative agent of TB, infecting more than 1/3 of the world's human population. MTB has adopted numerous features which contribute to its survival within the hostile environment. MTB has unique cell wall with high lipid content and displays a wide array of complex lipids and lipoglycans on its cell surface. Its cell wall is composed of 60% lipids, mainly mycolic acid (MA) which is responsible for low permeability of their cells to various antibiotics rendering drug resistance as well as the characteristic differential acid fast staining. Mycobacterial lipids which play an imperative role during the infection of MTB have been known to be involved in its pathogenicity. Certainly, closer view is required to further elucidate the role of lipids and many other lipid derivatives in establishment of MTB infection. Taken together, this review focuses on the significance of lipid molecule in MTB far from being just a building block of cell membrane and an energy reservoir to meet the energy expenses of the cell.




Iliac bone tuberculosis as an unusual cause of gluteal abscess

 

Gayathri Devi H.J. *, Vinay M.D. PrabhuBharathi V. Hiremath


The J of Chest Disease and Tuberculosis



Gayathri Devi H.J.*, Vinay M.D. Prabhu, Bharathi V. Hiremath receive Robert Koch Award-2014 for expanding knowledge in Chest Disease and Tuberculosis by Photon Foundation.


a Department of Respiratory Medicine, M.S. Ramaiah Medical College, Bangalore -560 054, India 

b Department of Radiology, M.S. Ramaiah Medical College, Bangalore - 560 054, India 

c Department of Surgery, M.S. Ramaiah Medical College, Bangalore-560054, India 

Keywords:tuberculosis, iliac bone, gluteal abscess 

Photon Ignitor: ISJN57438477D726330092014

Citation: Gayathri Devi H.J., Prabhu V.M.D., Hiremath B.V., 2014. Iliac bone tuberculosis as an unusual cause of gluteal abscess. The Journal of Chest Disease and Tuberculosis. Photon 107, 130 -133.

Abstract

Tuberculosis continues to be a major health problem and the most common presentation of tuberculosis is pulmonary tuberculosis. Extra-pulmonary tuberculosis can affect any organ in the body. We report a case of tubercular gluteal abscess in an immunocompetent male secondary to a tubercular lesion of the iliac bone. The patient also had a left pleural effusion which was not identified in the initial workup of the patient. Unusual site of the tubercular lesion lead to further evaluation with Magnetic resonance Imaging which revealed iliac bone tuberculosis. Osteoarticular tuberculosis is uncommon and iliac bone tuberculosis is a relatively rare entity. Early diagnosis of atypical presentation of extra-pulmonary tuberculsosis is important to reduce the morbidity associated with a curable disease.



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