The Journal for Cell Biology

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The Journal for Cell Biology, ISJN: 5743-8472, Impact Index: 5.98, Imprint: Photon, Category: Peer Reviewed Indexed International Journal


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Effect of chronic administration of carbofuran on mitochondrial and carbohydrate metabolizing enzymes


Ponnamparambil Purushothaman Binitha, Ramadasan Kuttan*  


Amala Cancer research Centre, Amala Nagar Thrissur-680 555, Kerala, India     


Ponnamparambil Purushothaman Binitha and Ramadasan Kuttan receive Camillo Golgi Research Award -2015 in Cell Biology


Abbreviations: Acetylcholonesterase (AchE), Lactate dehydrogenase (LDH), Ceatine Kinase (CK), γ-glutamyl transferase (γ-GT)  


Keywords:  Acetylcholinesterase inhibitor, mitochondrial dehydrogenases, glycolytic enzymes, gluconeogenic enzymes


Photon Ignitor: ISJN57438472D739021032015


Citation: Binitha P.P., Kuttan R., 2015. Effect of chronic administration of carbofuran on mitochondrial and carbohydrate metabolizing enzymes. The Journal for Cell Biology. Photon 106, 130-138.


Abstract 

Effect of long term oral administration (180 days) of low dose of carbofuran (5 mg/kg body weight) was evaluated on serum and different tissue enzymes of Wistar rats. The activities of mitochondrial enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and NADH dehydrogenase were decreased significantly in liver homogenate of carbofuran treated animals. Hexokinase activity was found to be significantly increased in liver during chronic administration of carbofuran to rats. Glucose-6-phoshate dehydrogenase, glucose-6-phosphatase and fructose 1, 6 bisphospatase were significantly decreased in carbofuran treated rats. In addition to these there was significant inhibition of acetylcholinesterase (AchE) and marked elevation of creatine kinase (CK), lactate dehydrogenase (LDH), and gamma glutamyl transferase (γ-GT) in serum and different tissues of treated animals. The findings of this study suggested that carbofuran induced oxidative stress caused damage to rat liver mitochondrial tissues by altering mitochondrial dehydrogenases as well as glycolytic and gluconeogenic enzymes. The results also indicated that carbofuran administration produced neurological failure in Wistar rats due to inhibition of AchE and elevated the activity of CK, LDH and γ-GT in serum and tissues indicating leakage of these enzymes from damaged tissues leading to specific organ toxicity.




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