The major focus of the Krug laboratory is the molecular biology of human influenza viruses (influenza A and B viruses), which cause widespread human disease. We are determining the molecular mechanisms of viral mRNA synthesis and viral RNA replication; and how the viral nonstructural proteins of these two influenza viruses contribute to pathogenesis and overcome host defense by inhibiting crucial cellular functions, including the 3’ end processing system used for the production of cellular pre-mRNAs, and the interferon-induced modification of proteins by the ISG15 ubiquitin-like protein. Our research has already identified promising new targets for the development of antivirals, which are now the subject of high-throughput screens. In addition, research on influenza A viruses includes the analysis of the functions of the genes of H5N1 avian influenza viruses, which have the potential for causing the next pandemic.
OFFICIAL Website: http://www.icmb.utexas.edu/research/krug
Telephone: (512)232-5563, (512)232-5564
The University of Texas at Austin
Molecular Biosciences, College of Natural Sciences
100 West 24th Street
Austin, TX 78712