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General information
Eplerenone is an aldosterone blocker. It works by blocking the hormone aldosterone, which lowers the amount of sodium and water the body retains. This helps to lower blood pressure to help prevent strokes, heart attacks, and kidney problems. It is also used to improve survival in patients who have certain heart problems (left ventricular systolic dysfunction and congestive heart failure) following a heart attack.
Directions
Take eplerenone by mouth with or without food. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. For congestive heart failure after a heart attack: Adults—At first, 25 milligrams (mg) once a day, then your dose may be increased to 50 mg once a day. For high blood pressure: Adults, teenagers, and children above 4 years of age—At first, 50 milligrams (mg) once a day. Your doctor may increase your dose to 50 mg two times a day.
Precautions
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Do not use eplerenone if you have severe kidney problems or high blood potassium levels, you are taking eplerenone to treat high blood pressure, and you have type 2 diabetes with protein in your urine, you are taking clarithromycin, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, or troleandomycin, you are taking eplerenone to treat high blood pressure, and you are taking potassium supplements or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene).
Contraindications
Some medical conditions may interact with eplerenone. Tell your doctor or pharmacist if you have any medical conditions, especially if you are pregnant, planning to become pregnant, or are breast-feeding, if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement, if you have allergies to medicines, foods, or other substances, if you have kidney problems, diabetes, or protein in your urine and if you have a history of high blood potassium levels.
Possible side effect
This medicine may increase the amount of potassium in your blood. Check with your doctor right away if you are having abdominal or stomach pain; nausea or vomiting; nervousness; difficulty with breathing; irregular heartbeats; confusion; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.
Drug interactions
The medications that may interact with Inspra are Lithium because the risk of its side effects may be increased by eplerenone; Azole antifungals (eg, fluconazole, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin ), nefazodone, protease inhibitors (eg, nelfinavir, ritonavir, saquinavir), or verapamil because they may increase the risk of eplerenone's side effects; Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen) because they may decrease eplerenone's effectiveness and increase the risk of high blood potassium levels and Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin-receptor blockers (eg, valsartan), potassium supplements, or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene) because the risk of high blood potassium levels may be increased.
Missed dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Overdose
Overdosing can result in several symptoms like slow heart beat, dizziness, weak pulse rate, feeling like losing consciousness, weakness in muscles etc. You may also suffer from severe side effects such as allergic reactions (rashes, itching, swelling in mouth/lips/tongue/throat, difficulty in breathing etc), pain in the chest, unusual vaginal bleeding, sore or enlarged breasts (if you are male), palpitation, persistent diarrhoea, vomiting or swelling in the feet or ankles. Contact your physician immediately if you have accidentally overdosed and are experiencing any of the above symptoms.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.
Note
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.

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