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MAGIC

MAGIC is the multiparent advanced generation intercross. It is a simple extension of the advanced intercross of Darvasi and Soller in which an  intercrossed mapping population is created from multiple founder lines, typically 8. In comparison to mapping in bi-parental crosses, the increased recombination and diversity of MAGIC gives greater precision in QTL location and greater opportunity to detect more QTL for multiple traits. The populations can also be used as training populations for genomic selection, in which the equations to predict breeding value will be unaffected by the major population subdivisions which are commonly found in breeding programmes and collections of cultivars.The method  was first proposed and applied to mice as 'heterogeneous stock," a description which doesn't work well for plants. The term MAGIC was first coined by Mackay and Powell  and advocated by them and  Cavanagh et al. for crops. These populations take time to develop, but results are expected from an Australian wheat population this year. I am aware of populations  in development in bread wheat (NIAB, CSIRO), durum wheat (University of Bologna), oats (IBERS), barley (SAC), sorghum (ICRISAT), rice (IIRI) and cowpea (IITA). Some results from an Arabidopsis population have already been published. If you know of any others, let me know.

A collection of papers was published in the February edition of Genetics and of G3: Genes, Genomes Genetics on the Collaborative Cross in mouse.  Reviewed here

My involvement is in the development of populations at NIAB for winter wheat. In BBSRC funded work, we have developed 1,000 inbred lines from each of four populations and are now seeking funding to test these. 

Update: still no funding, but we have now have some phenotype data from a 2.6 ha trial of the lines and are waiting delivery of 90k SNP data on about half of these: all we could afford.