Ph. D. Hyun Gyu Lim

Google Scholar CV pdf

Address: Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Korea

Tel: +82-54-279-2935

Fax: +82-54-279-5528

E-mail: hyungyu.lim_AT_postech.ac.kr

Research Interests

1. Metabolic engineering and synthetic biology

2. Improved utilization of abundant carbons in nature

3. Design and optimization of metabolic pathway for value-added chemicals

4. Evolutionary engineering of microorganisms

Educational Background

2011. 03. – 2017. 02. Ph. D. in Chemical Engineering

Pohang University of Science and Technology (POSTECH), Korea

Thesis: Synthetic design and optimization of metabolic pathway for efficient conversion of low-cost carbon sources to value-added Bio-chemicals

Advisor: Gyoo Yeol Jung

2006. 03. – 2011. 02. B. S. in Chemical Engineering

Pohang University of Science and Technology (POSTECH), Korea

Professional Experiences

2017. 02. – 2018.03. Postdoctoral Research Associate

Pohang University of Science and Technology (POSTECH), Korea

Advisor: Gyoo Yeol Jung

2018. 04. – current Research Assistant Professor

Pohang University of Science and Technology (POSTECH), Korea

Advisor: Gyoo Yeol Jung

Peer reviewed articles

Full List of Papers (17): Published (14), under revision (2), submitted (1)

17. S Cha*, HG Lim*, MF Haase, GY Jung, D Lee, Bijel, Efficient enzymatic conversion of insoluble chemicals using bicontinuous interfacially jammed emulsion gels (bijel), submitted

16. S Jang, S Jang, MH Noh, HG Lim, GY Jung, Novel hybrid input part using riboswitch and transcriptional repressor for signal inverting amplifier, under revision

15. S Jang, HG Lim, J Yang, SW Seo, GY Jung, Synthetic regulatory tools to engineer microbial cell factories for chemical production (book chapter), under revision

14. SG Kim, MH Noh, HG Lim, S Jang, S Jang, GY Jung, Molecular parts and genetic circuits for metabolic engineering of microorganisms (review), FEMS Microbiology Letters, accepted, doi:10.1093/femsle/fny187

13. HG Lim*, S Jang*, S Jang, SW Seo, GY Jung, Design and optimization of genetically encoded biosensors for high-throughput screening of chemicals (review), Current Opinion in Biotechnology, 2018 Dec; 54:18-25, doi:10.1016/j.copbio.2018.01.011

12. CW Kang*, HG Lim*, J Yang, MH Noh, SW Seo, GY Jung, Synthetic auxotrophs for stable and tunable maintenance of plasmid copy number, Metabolic Engineering, 2018 Jul, 48:121-128, doi:10.1016/j.ymben.2018.05.020

11. JY Seok, J Yang, SJ Choi, HG Lim, K Kim, S Park, TH Yoo, GY Jung, Directed evolution of the 3-hydroxypropionic acid production pathway by engineering aldehyde dehydrogenase using a synthetic selection device, Metabolic Engineering, 2018 May; 47:113-120, doi:10.1016/j.ymben.2018.03.009

10. HG Lim*, JH Lee*, MH Noh, GY Jung, Rediscovering acetate metabolism: its potential sources and utilization for bio-based transformation into value-added chemicals (review), Journal of Agricultural and Food Chemistry, 2018 Apr; 66(16) 3998-4006, doi:10.1021/acs.jafc.8b00458

9. MH Noh*, HG Lim*, SH Woo, J Song, GY Jung, Production of itaconic acid from acetate by engineering acid-tolerant Escherichia coli W, Biotechnology and Bioengineering, 2018 Mar;115(3):729-738, doi: 10.1002/bit.26508, doi:10.1002/bit.26508

8. MH Noh*, HG Lim*, S Park, SW Seo, GY Jung, Precise flux redistribution to glyoxylate cycle for 5-aminolevulinic acid production in Escherichia coli, Metabolic Engineering, 2017 Sep;43:1-8, doi:10.1016/j.ymben.2017.07.006

7. DH Kwak*, HG Lim*, J Yang, SW Seo, GY Jung, Synthetic redesign of Escherichia coli for cadaverine production from galactose, Biotechnology for Biofuels, 2017 Jan;10:20, doi:10.1186/s13068-017-0707-2

6. BE Min, HG Hwang, HG Lim, GY Jung, Optimization of industrial microorganisms: recent advances in synthetic dynamic regulators (review), Journal of Industrial Microbiology & Biotechnology, 2017 Jan;44(1):89-98 (IF2016=2.810) Selected as a cover paper, doi:10.1007/s10295-016-1867-y

5. HG Lim, MH Noh, JH Jeong, S Park, GY Jung, Optimum rebalancing of the 3-hydroxypropionic acid production pathway from glycerol in Escherichia coli, ACS Synthetic Biology, 2016 Nov;5(11):1247-1255, doi: 10.1021/acssynbio.5b00303

4. HG Lim*, JH Lim*, GY Jung, Modular design of metabolic network for robust production of n-butanol from galactose-glucose mixtures, Biotechnology for Biofuels, 2015 Sep;8:137, doi:10.1186/s13068-015-0327-7

3. HG Lim, DH Kwak, GY Jung, Biofuel production from macroalgae toward bio-based economy (review), Journal of Marine Bioscience and Biotechnology, 2014 Jul:8-16, doi: 10.15433/ksmb.2014.6.1.008

2. SW Seo, J Yang, BE Min, S Jang, JH Lim, HG Lim, SC Kim, SY Kim, J Jeong, GY Jung, Synthetic biology: tools to design microbes for the production of chemicals and fuels (review), Biotechnology Advances, 2013 Nov;31(6):811-817, doi:10.1016/j.biotechadv.2013.03.012

1. HG Lim*, SW Seo*, GY Jung, Engineered Escherichia coli for simultaneous utilization of galactose and glucose, Bioresource Technology, 2013 May;135:564-567, doi:10.1016/j.biortech.2012.10.124

Selected Presentations

8. HG Lim, MH Noh, CW Kang, SW Seo, GY Jung, Accelerating microbial production of value-added biochemicals via precise control of gene expression in Escherichia coli, i-BioS, Singapore (Dec 18-20, 2017) as an oral presentation

7. HG Lim, MH Noh, JH Jung, S Park, GY Jung, Synthetic Design and Optimization of Biosynthetic Pathway for 3-Hydroxypropionic Acid Production in Escherichia coli, i-BioP, Busan, Korea (Dec 16-18, 2016) as an oral presentation

6. HG Lim, MH Noh, JH Jung, S Park, GY Jung, Optimal Pathway Rebalancing for 3-Hydroxypropionic acid Production from glycerol in Escherichia coli, 251st ACS National Meeting & Exposition, San Diego, United States (Mar 10-14, 2015) as an oral presentation

5. HG Lim, JH Lim, GY Jung, Modular Engineering for Robust n-Butanol Production from Galactose-Glucose mixtures in Escherichia coli, The 12th Asian Congress on Biotechnology (ACB 2015), Kuala Lumpur, Malaysia (Nov 15-19, 2015) as an oral presentation

4. HG Lim, JH Lim, GY Jung, Optimization of Modular Pathway for Production n-Butanol from Red Seaweed Hydrolysate in Escherichia coli, 5th International Conference on Biomolecular Engineering, Texas, United States (Jan 11-14, 2015) as a poster presentation

3. HG Lim, JH Lim, GY Jung, Enhanced Utilization of Non-Favored Sugars from Marine Biomass By Re-Designed Escherichia coli, Metabolic Engineering X, Vancouver, Canada (June 15-19, 2014) as a poster presentation.

2. HG Lim, SW Seo, GY Jung, Simultaneous Utilization of Galactose and Cellobiose by Engineered Escherichia coli, 245th ACS National Meeting & Exposition, New Orleans, United States (Apr, 7-11, 2013) as an oral presentation

1. HG Lim, SW Seo, GY Jung, Simultaneous Utilization of Glucose and Galactose by Re-design of Galactose Metabolism pathway in Escherichia coli, 15th International Biotechnology Symposium(IBS) and Exhibition, Korea (Sep, 16-21, 2012) as a poster presentation

Awards and Honors

2006 – 2011 The Korean Presidential Scholarship supported by Korean Government

Dec, 2011 Member of Young Engineers Honor Society (NAEK-YEHS) supported by the National Academy of Engineering of Korea

April, 2012 Best Student Poster Award at Korean Society for Biotechnology and Bioengineering, Spring Meeting, Korea

October, 2012 Best Student Poster Award at the Korean Institute of Chemical Engineering Fall Meeting, Korea

April, 2014 Best Oral Presentation Award at Korean Society for Biotechnology and Bioengineering Fall Meeting, Korea

May, 2017 Best Student Poster Award at the Korean Society of Industrial and Engineering Chemistry Spring Meeting, Korea (with Sanghak Cha)

Nov, 2017 Best Oral Presentation Award at the Korean Society of Industrial and Engineering Chemistry Spring Meeting, Korea (with Myung Hyun Noh)

Jan, 2018 Best Student Poster Award at the ICBE Asia 2018: International Conference on Biomolecular Engineering, Korea (with Sanghak Cha)