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The majority of animal genes are required for wild-type fitness. Ramani AK, Chuluunbaatar T, Verster AJ, Na H, Vu V, Pelte N, Wannissorn N, Jiao A, Fraser AG. Cell. 2012 Feb 17;148(4):792-802.


Genome-wide analysis of alternative splicing in Caenorhabditis elegans. Ramani AK, Calarco JA, Pan Q, Mavandadi S, Wang Y, Nelson AC, Lee LJ, Morris Q, Blencowe BJ, Zhen M, Fraser AG. Genome Res. 2011 Feb;21(2):342-8. Epub 2010 Dec 22.


Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation. Ip JY, Schmidt D, Pan Q, Ramani AK, Fraser AG, Odom DT, Blencowe B. Genome Res. 2010 Dec 16.


Predicting genetic modifier loci using functional gene networks. Lee I, Lehner B, Vavouri T, Shin J, Fraser AG, Marcotte EM. Genome Res. 2010 Aug;20(8):1143-53. Epub 2010 Jun 9.


High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans. Ramani AK, Nelson AC, Kapranov P, Bell I, Gingeras TR, Fraser AG. Genome Biol. 2009;10(9):R101.

Evolutionary plasticity of genetic interaction networks. Tischler J, Lehner B, Fraser AG. Nat Genet. 2008 Apr;40(4):390-1. Epub 2008 Mar 23.


A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Lee I, Lehner B, Crombie C, Wong W, Fraser AG, Marcotte EM. Nat Genet. 2008 Feb;40(2):181-8. Epub 2008 Jan 27.


Minimizing the risk of reporting false positives in large-scale RNAi screens. Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prévôt B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R. Nat Methods. 2006 Oct;3(10):777-9.


Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands. Teng MS, Dekkers MP, Ng BL, Rademakers S, Jansen G, Fraser AG, McCafferty J. BMC Biol. 2006 Jul 20;4:22.


Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Lehner B, Crombie C, Tischler J, Fortunato A, Fraser AG. Nat Genet. 2006 Aug;38(8):896-903. Epub 2006 Jul 16.


Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Lehner B, Calixto A, Crombie C, Tischler J, Fortunato A, Chalfie M, Fraser AG. Genome Biol. 2006;7(1):R4. Epub 2006 Jan 20.


Uncover genetic interactions in Caenorhabditis elegans by RNA interference. Fortunato A, Fraser AG. Biosci Rep. 2005 Oct-Dec;25(5-6):299-307. Review.


Systems biology: where it's at in 2005. Lehner B, Tischler J, Fraser AG. Genome Biol. 2005;6(8):338. Epub 2005 Aug 1.


Treating genetic disease through RNA interference. Crombie C, Fraser A.Lancet. 2005 Apr 9-15;365(9467):1288-90.


5,000 RNAi experiments on a chip. Lehner B, Fraser AG. Nat Methods. 2004 Nov;1(2):103-4.


Protein domains enriched in mammalian tissue-specific or widely expressed genes. Lehner B, Fraser AG. Trends Genet. 2004 Oct;20(10):468-72.


A first-draft human protein-interaction map. Lehner B, Fraser AG. Genome Biol. 2004;5(9):R63. Epub 2004 Aug 13.


Development through the eyes of functional genomics. Fraser AG, Marcotte EM. Curr Opin Genet Dev. 2004 Aug;14(4):336-42. Review.


A probabilistic view of gene function. Fraser AG, Marcotte EM. Nat Genet. 2004 Jun;36(6):559-64. Review.


Technique review: how to use RNA interference. Lehner B, Fraser AG, Sanderson CM. Brief Funct Genomic Proteomic. 2004 Apr;3(1):68-83. Review.


RNA interference: human genes hit the big screen. Fraser A. Nature. 2004 Mar 25;428(6981):375-8.


The not-so-humble worm. Crombie C, Junio A, Fraser A. Genome Biol. 2003;5(1):301. Epub 2003 Dec 15.


Worms in L.A. Fraser A. Nat Genet. 2003 Sep;35(1):3-5.


Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. Nature. 2003 Jul 17;424(6946):277-83. Epub 2003 Jun 29.


Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, van Haaften G, Thijssen K, Kamath RS, Fraser AG, Ahringer J, Plasterk RH, Tijsterman M. Genes Dev. 2003 Feb 15;17(4):443-8.


Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Nature. 2003 Jan 16;421(6920):268-72.


Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J. Nature. 2003 Jan 16;421(6920):231-7.


Rates of behavior and aging specified by mitochondrial function during development. Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C. Science. 2002 Dec 20;298(5602):2398-401. Epub 2002 Dec 5.


A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Nat Genet. 2003 Jan;33(1):40-8. Epub 2002 Nov 25.