Dr. Harekrushna Sahoo
The response of proteins towards different environmental conditions, namely binding and non-binding entities, is not understood clearly in order to correlate with in vivo stability. We are addressing this problem in a variety of ways, such as environmental effects like ligand/dye/drug binding, effect of co-solvents (Ionic Liquids), effect of glycosaminoglycan (GAG; one of the major components of extracellular matrix) and different glucose molecules on protein stability and dynamics. (Details are in "Research" page)
We are also interested in digging out the folding pathways (specifically, the physical and thermodynamic parameters) affected by the above-said binding and non-binding molecules directly or indirectly on the protein of interest. We are using the "bottom-up" approach, where we are mimicking the cellular components in in vitro.