Research interests

 
 
We run a research group in the Department of Genetics and Genome Biology at the University of Leicester.

Our research focuses on human genetic diversity, its evolutionary origin and its phenotypic consequences. In particular, we are interested in the evolution and genetic variation of human genes in dynamic regions of the human genome, and the relationship of this variation with disease.



Research Project 1

DNA sequence differences between people are known to be important variables when trying to understand why individuals are different, particularly in susceptibility to disease. Most people have two copies of most genes: one inherited from their father, one from their mother. However, for some genes, including many involved in the immune response against infection, individuals have more or fewer than two copies. This is caused by duplication or deletion of genes on some chromosomes carried by those people, and we call this “copy number variation”. We are interested in how these changes evolve and their consequences for disease.
 
Research project 2

Copy number variation can also occur in the somatic tissue of the body. Some cancers show a high level of copy number changes that distinguish the tumour from healthy tissue. We are using evolutionary genomic approaches to understand the copy number changes in the asbestos-related cancer called mesothelioma. This will allow us to identify key weaknesses in the tumour to act as targets for new drugs. For more on our work on mesothelioma, click on this link Mesothelioma research

We are always interested in keen potential PhD students and postdocs - if you are interested in our work then please email me
ejh33(at)le.ac.uk

Dr. Edward J. Hollox
Below: A view of the University of Leicester campus from Victoria Park