Our research focuses on human genetic diversity, its evolutionary origin and its phenotypic consequences. In particular, we are interested in the evolution and genetic variation of human genes in dynamic regions of the human genome, and the relationship of this variation with susceptibility to disease.
DNA sequence differences between people are known to be important variables when trying to understand why individuals are different, particularly in susceptibility to disease. Most people have two copies of most genes: one inherited from their father, one from their mother. However, for some genes, including many involved in the immune response against infection, individuals have more or fewer than two copies. This is caused by duplication or deletion of genes on some chromosomes carried by those people, and we call this “copy number variation”. Both copy number and DNA sequence variation can exist together – for example a gene which could be present once, twice or three times on a chromosome could have polymorphic sequence differences between each copy.
We have several projects in the lab, for more information email me.
We are always interested in keen potential PhD students and postdocs - if you are interested in our work then please email me
Dr. Edward J. Hollox
Below: A view of the University of Leicester campus from Victoria Park